Expression of CD163 (hemoglobin scavenger receptor) in normal tissues, lymphomas, carcinomas, and sarcomas is largely restricted to the monocyte/macrophage lineage

American Journal of Surgical Pathology

Volumn 29, Issue 5, 2005, Pages 617-624

  Nguyen, TuDung T ^a   Schwartz, Erich J ^a   West, Robert B ^a   Warnke, Roger A ^a   Arber, Daniel A ^a   Natkunam, Yasodha ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD163; Histiocyte; Immunohistochemistry; Macrophage; Monocyte

Indexed keywords

CD163 ANTIGEN; CD68 ANTIGEN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CARCINOMA; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; DERMATOFIBROMA; DIFFERENTIAL DIAGNOSIS; FIBROXANTHOMA; FOLLICULAR DENDRITIC CELL; GIANT CELL TUMOR; HISTIOCYTE; HISTIOCYTIC SARCOMA; HISTIOCYTOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOMA; MACROPHAGE; MESENCHYME; MONOCYTE; PROTEIN EXPRESSION; ROSAI DORFMAN DISEASE; SARCOMA; TISSUE MICROARRAY; TISSUE SPECIFICITY;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CARCINOMA; CELL LINEAGE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOMA; MACROPHAGES; MALE; MONOCYTES; PROTEIN ARRAY ANALYSIS; RECEPTORS, CELL SURFACE; SARCOMA; TUMOR MARKERS, BIOLOGICAL;

EID: 17744387919     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000157940.80538.ec     Document Type: Article

References (35)

1. Arber DA, Strickler JC, Chen YY, et al. Splenic vascular tumors: a histologic, immunophenotypic, and virologic study. Am J Surg Pathol 1997;21:827-835.
2. Binder SW, Said JW, Shintaku P, et al. A histiocyte-specific marker in the diagnosis of malignant fibrous histiocytoma: use of monoclonal antibody KP-1 (CD68). Am J Clin Pathol 1992;97:759-763.
3. Buechler C, Ritter M, Orso E, et al. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli. J Leukoc Biol. 2000;67:97-103.
4. Carbone A, Gloghini A, Volpe R, et al. KPI (CD68)-positive large cell lymphomas: a histopathologic and immunophenotypic characterization of 12 cases. Hum Pathol. 1993;24:886-896.
5. Davey FR, Erber WN, Gatter KC, et al. The use of monoclonal antibody Y1/82A in the identification of acute myeloblastic and monocytic leukemias. Am J Clin Pathol. 1988;89:76-80.
6. Dei Tos AP, Doglioni C, Laurino L, et al. KPI (CD68) expression in benign neural tumours: further evidence of its low specificity as a histiocytic/myeloid marker. Histopathology. 1993;23:185-187.
7. Doussis IA, Gatter KC, Mason DY. CD68 reactivity of non-macrophage derived tumours in cytologiesl specimens. J Clin Pathol. 1993;46: 334-336.
8. Eisen RN, Buckley PJ, Rosai J. Immunophenotypic characterization of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Semin Diagn Pathol. 1990;7:74-82.
9. Facchetti F, Bertalot G, Grigolato PG. KPI (CD68) staining of malignant melanomas. Histopathology. 1991;19:141-145.
10. Facchetti F, Wolf-Peeters CD, Vos RD, et al. Plasmacytoid monocytes (so-called plasinacytoid T cells) in granulomatous lymphadenitis. Hum Pathol. 1989;20:588-593.
11. Fan Z, van de Rijn M, Montgomery K, et al. Hep par 1 antibody stain for the differential diagnosis of hepatocellular carcinoma: 676 tumors tested using tissue microarrays and conventional tissue sections. Mod Pathol. 2003;16:137-144.
12. Fonseca JE, Edwards JC, Blades S, et al. Macrophage subpopulations in rheumatoid synovium: reduced CD163 expression in CD4+ T lymphocyte-rich microenvironments. Arthritis Rheum. 2002;46:1210-1216.
13. Furlong MA, Motamedi K, Laskin WB, et al. Synovial-type giant cell tumors of the vertebral column: a clinicopathologic study of 15 cases, with a review of the literature and discussion of the differential diagnosis. Hum Pathol. 2003;34;670-679.
14. Gloghini A, Volpe R, Canzonieri V, et al. Immunohistochemical characterization of Ki-M6 monoclonal antibody in Bouin-fixed, paraffin-embedded sections of normal and neoplastic human tissues. Virchows Archiv A Pathol Anat. 1991;418:355-360.
15. Graversen JH, Madsen M, Moestrup SK. CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma. Int J Biochem Cell Biol. 2002;34:309-314.
16. Hanson CA, Jaszcz W, Kersey JH, et al. True histiocytic lymphoma: histopathologic, immunophenotypic and genotypic analysis. Br J Haematol. 1989;73:187-198.
17. Hugger P, Dreier J, Droste A, et al. Identification of the integral membrane protein RM3/1 on human monocytes as a glucocorticoid-inducible member of the scavenger receptor cysteine-rich family (CD163). J Immunol. 1998; 161:1883-1890.
18. Hugger P, Sorg C. Soluble CD163 inhibits phorbol ester-induced lymphocyte proliferation. Biochem Biophys Res Commun. 2001;288: 841-843.
19. Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med. 1998; 4:844-847.
20. Kristiansen M, Graversen JH, Jacobsen C, et al. Identification of the haemoglobin scavenger receptor. Nature. 2001;409:198-201.
21. Law SK, Micklem KJ, Shaw JM, et al. A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily. Eur J Immunol. 1993;23:2320-2325.
22. Longacre TA, Smoller BR, Rouse RV. Atypical fibroxanthoma: multiple immunohistologic profiles. Am J Surg Pathol. 1993;17:1199-1209.
23. Moller HJ, Peterslund NA, Graversen JH, et al. Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma. Blood. 2002;99:378-380.
24. Natkunam Y, Warnke RA, Montgomery K, et al. Analysis of MUM1/TRF4 protein expression using tissue microarrays and immunohistochemistry. Mod Pathol. 2001;14:686-694.
25. Pileri SA, Grogan TM, Harris NL, et al. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology. 2002;41:1-29.
26. Pulford K, Micklem K, McCarthy S, et al. A monocyte/macrophage antigen recognized by the four antibodies GHI/61, Ber-MAC3, Ki-M8 and SM4. Immunology. 1992;75:588-595.
27. Schaer DI. The macrophage hemoglobin scavenger receptor (CD163) as a genetically determined disease modifying pathway in atherosclerosis. Atherosclerosis. 2002;163:199-201.
28. Schaer DJ, Boretti FS, Schoedon G, et al. Induction of the CD163-independent haemoglobin uptake by macrophages as a novel anti-inflammatory action of glucocorticoids. Br J Haematol. 2002;119:239-243.
29. Smith MEF, Costa MJ, Weiss SW. Evaluation of CD68 and other histiocytic antigens in angiomatoid malignant fibrous histiocytoma. Am J Surg Pathol. 1991;15:757-763.
30. Stover CM, Schleypen J, Gronlund J, et al. Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis. Cytogenet Cell Genet. 2000;90:246-247.
31. Sulahian TH, Hogger P, Wahner AE, et al. Human monocytes express CD163, which is upregulated by IL-10 and identical to p155. Cytokine. 2000;12:1312-1321.
32. Tsang WYW, Chan JKC. KP1 (CD68) staining of granular cell neoplasms: is KP1 a marker for lysosomes rather than the histiocytic lineage? Histopathology. 1992;21:84-S6.
33. Vermi W, Facchetti F, Rosati S, et al. Nodal and extranodal tumor-forming accumulation of plasmacytoid onocytes/interferon-producing cells associated with myeloid disorders. Am J Surg Pathol. 2004;28:585-595.
34. Walter RB, Bachli EB, Schaer DJ, et al. Expression of the hemoglobin scavenger receptor (CD163/IIbSR) as immunophenotypic marker of monocytic lineage in acute myeloid leukemia. Blood. 2003;101:3755-3756.
35. West RB, Harvell J, Linn SC, et al. Apo D in soft tissue tumors: a novel marker for dermatofibrosarcoma prutuberans. Am J Surg Pathol. 2004;28: 1063-1069.