High Growth Rate of Girls with Precocious Puberty Exposed to Estrogenic Mycotoxins

Journal of Pediatrics

Volumn 152, Issue 5, 2008, Pages

  Massart, Francesco ^a   Meucci, Valentina ^a   Saggese, Giuseppe ^a   Soldani, Giulio ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ZEARALENOL; TRIPTORELIN; ZEARALENONE;

ARTICLE; BLOOD ANALYSIS; BODY HEIGHT; BODY MASS; BODY WEIGHT; BONE AGE; CLINICAL ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; GROWTH RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PATHOGENESIS; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; SEXUAL DEVELOPMENT;

EID: 41849103083     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2007.10.020     Document Type: Article

References (35)

1. Parent A.S., Teilmann G., Juul A., Skakkebaek N.E., Toppari J., and Bourguignon J.P. The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration. Endocr Rev 24 (2003) 668-693
2. Krstevska-Konstantinova M., Charlier C., Craen M., Du Caju M., Heinrichs C., de Beaufort C., et al. Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochlorine pesticides. Hum Reprod 16 (2001) 1020-1026
3. De Felip E., di Domenico A., Miniero R., and Silvestroni L. Polychlorobiphenyls and other organochlorine compounds in human follicular fluid. Chemosphere 54 (2004) 1445-1449
4. Fara G.M., Del Corvo G., Bernuzzi S., Bigatello A., Di Pietro C., Scaglioni S., et al. Epidemic of breast enlargement in an Italian school. Lancet 2 (1979) 295-297
5. EU Council Directive 85/649/EEC, 1985.
6. Directive of The European Parliament and of the Council 96/22/EC, 1996.
7. Saenz de Rodriguez C.A., Bongiovanni A.M., and Conde de Borrego L. An epidemic of precocious development in Puerto Rican children. J Pediatr 107 (1985) 393-396
8. Saenz de Rodriguez C.A. Environmental hormone contamination in Puerto Rico. N Engl J Med 310 (1984) 1741-1742
9. Larriuz-Serrano M.C., Perez-Cardona C.M., Ramos-Valencia G., and Bourdony C.J. Natural history and incidence of premature thelarche in Puerto Rican girls aged 6 months to 8 years diagnosed between 1990 and 1995. PR Health Sci 20 (2001) 13-18
10. Comas A.P. Precocious sexual development in Puerto Rico. Lancet 1 (1982) 1299-1300
11. Schoental R. Precocious sexual development in Puerto Rico and oestrogenic mycotoxins (zearalenone). Lancet 1 (1983) 537
12. Szuets P., Mesterhazy A., Falkay G.Y., and Bartok T. Early thelarche symptoms in children and their relations to zearalenon contamination in foodstuffs. Cereal Res Commun 25 (1997) 429-436
13. Shier W.T., Shier A.C., Xie W., and Mirocha C.J. Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins. Toxicon 39 (2001) 1435-1438
14. Leffers H., Naesby M., Vendelbo B., Skakkebaek N.E., and Jorgensen M. Oestrogenic potencies of Zeranol, oestradiol, diethylstilboestrol, Bisphenol-A and genistein: implications for exposure assessment of potential endocrine disrupters. Hum Reprod 16 (2001) 1037-1045
15. Takemura H., Shim J.Y., Sayama K., Tsubura A., Zhu B.T., and Shimoi K. Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro. J Steroid Biochem Mol Biol 103 (2007) 170-177
16. Massart F., Seppia P., Pardi D., Lucchesi S., Meossi C., Gagliardi L., et al. High incidence of central precocious puberty in a bounded geographic area of northwest Tuscany: an estrogen disrupter epidemic?. Gynecol Endocrinol 20 (2005) 92-98
17. Massart F., Harrell J.C., Federico G., and Saggese G. Thyroid outcome during long-term gonadotropin-releasing hormone agonist treatments for idiopathic precocious puberty. J Adolesc Health 40 (2007) 252-257
18. Iughetti L., Predieri B., Ferrari M., Gallo C., Livio L., Milioli S., et al. Diagnosis of central precocious puberty: endocrine assessment. J Pediatr Endocrinol Metab 13 (2000) 709-715
19. Cacciari E., Milani S., Balsamo A., Spada E., Bona G., Cavallo L., et al. Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr). J Endocrinol Invest 29 (2006) 581-593
20. Miller J.D. Aspects of the ecology of Fusarium toxins in cereals. Adv Exp Med Biol 504 (2002) 19-27
21. Joint FAO/WHO Expert Committee on Food Additive (JECFA). 53rd report: safety evaluation of certain food additives; WHO Food Additives Series. vol. 44 (2000), WHO, Geneva, Switzerland
22. European Commission, Health and Consumer Protection Directorate-General. Opinion of the Scientific Committee on Food on Fusarium Toxins. Part 2: Zearalenone. Bruxelles: 2000.
23. Danicke S., Swiech E., Buraczewska L., and Ueberschar K.H. Kinetics and metabolism of zearalenone in young female pigs. J Anim Physiol Anim Nutr 89 (2005) 268-276
24. Kleinova M., Zollner P., Kahlbacher H., Hochsteiner W., and Lindner W. Metabolic profiles of the mycotoxin zearalenone and of the growth promoter zeranol in urine, liver, and muscle of heifers. J Agric Food Chem 50 (2002) 4769-4776
25. Apple J.K., Dikeman M.E., Simms D.D., and Kuhl G. Effects of synthetic hormone implants, singularly or in combinations, on performance, carcass traits, and longissimus muscle palatability of Holstein steers. J Anim Sci 69 (1991) 4437-4448
26. Lemieux P.G., Byers F.M., and Schelling G.T. Relationship of anabolic status and phase and rate of growth to priorities for protein and fat deposition in steers. J Anim Sci 68 (1990) 1702-1710
27. Moran C., Quirke J.F., Prendiville D.J., Bourke S., and Roche J.F. The effect of estradiol, trenbolone acetate, or zeranol on growth rate, mammary development, carcass traits, and plasma estradiol concentrations of beef heifers. J Anim Sci 69 (1991) 4249-4258
28. Williams J.E., Ireland S.J., Mollett T.A., Hancock D.L., Beaver E.E., and Hannah S. Influence of zeranol and breed on growth, composition of gain, and plasma hormone concentrations. J Anim Sci 69 (1991) 1688-1696
29. Tiemann U., and Danicke S. In vivo and in vitro effects of the mycotoxins zearalenone and deoxynivalenol on different non-reproductive and reproductive organs in female pigs: a review. Food Addit Contam 24 (2007) 306-314
30. Pillay D., Chuturgoon A.A., Nevines E., Manickum T., Deppe W., and Dutton M.F. The quantitative analysis of zearalenone and its derivatives in plasma of patients with breast and cervical cancer. Clin Chem Lab Med 40 (2002) 946-951
31. Migdalof B.H., Dugger H.A., Heider J.G., Coombs R.A., and Terry M.K. Biotransformation of zeranol: disposition and metabolism in the female rat, rabbit, dog, monkey and man. Xenobiotica 13 (1983) 209-221
32. Nagel S.C., vom Saal F.S., and Welshons W.V. The effective free fraction of estradiol and xenoestrogens in human serum measured by whole cell uptake assays: physiology of delivery modifies estrogenic activity. Proc Soc Exp Biol Med 217 (1998) 300-309
33. Moran C., Prendiville D.J., Quirke J.F., and Roche J.F. Effects of oestradiol, zeranol or trenbolone acetate implants on puberty, reproduction and fertility in heifers. J Reprod Fertil 89 (1990) 527-536
34. Antoniazzi F., Bertoldo F., Lauriola S., Sirpresi S., Gasperi E., Zamboni G., et al. Prevention of bone demineralization by calcium supplementation in precocious puberty during gonadotropin-releasing hormone agonist treatment. J Clin Endocrinol Metab 84 (1999) 1992-1996
35. Lampit M., Golander A., Guttmann H., and Hochberg Z. Estrogen mini-dose replacement during GnRH agonist therapy in central precocious puberty: a pilot study. J Clin Endocrinol Metab 87 (2002) 687-690