Scope of the asymmetric intramolecular stetter reaction catalyzed by chiral nucleophilic triazolinylidene carbenes

Journal of Organic Chemistry

Volumn 73, Issue 6, 2008, Pages 2033-2040

  De Alaniz, Javier Read ^a   Kerr, Mark S ^a   Moore, Jennifer L ^a   Rovis, Tomislav ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; CATALYSIS; ENANTIOSELECTIVITY; REACTION KINETICS; SULFUR;

ALIPHATIC ALDEHYDES; ASYMMETRIC INTRAMOLECULAR STETTER REACTIONS; TRIAZOLIUM SCAFFOLDS;

OLEFINS;

ALDEHYDE; ALDEHYDE DERIVATIVE; AMIDE; CARBENOID; CARBON; ESTER DERIVATIVE; KETONE DERIVATIVE; NITRILE; NITROGEN; OXYGEN; SULFUR; THIOESTER;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHIRALITY; CYCLIZATION; ELECTRON; ENANTIOMER; ENANTIOSELECTIVITY;

ALDEHYDES; ALKENES; BENZALDEHYDES; CATALYSIS; HYDROCARBONS; METHANE; MODELS, MOLECULAR; STEREOISOMERISM; TRIAZOLES;

EID: 41849101072     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo702313f     Document Type: Article

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57. This model is an MM2 minimization (Chem 3D) of the catalyst framework and substrate, followed by simple manipulation of the substituents within that software, and is meant to serve as a mnemonic rather than a transition state approximation. We are currently engaged in a collaboration to provide theoretical and computational support for this model.