Quantitative determination of nitrendipine in human plasma using high-performance liquid chromatography-mass spectrometry

Arzneimittel-Forschung/Drug Research

Volumn 58, Issue 3, 2008, Pages 111-116

  Liu, Ying ^a   Xu, Feng Guo ^a   Zhang, Zun Jian ^a   Song, Rui ^a   Tian, Yuan ^a   Chen, Yun ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Calcium antagonists, 1,4 dihydropyridine; CAS 39562 70 4; Nitrendipine, bioavailability, LC MS method, pharmacokinetics

Indexed keywords

HEXANOL; METHANOL; NIMODIPINE; NITRENDIPINE; WATER;

ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; NORMAL HUMAN; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE;

EID: 41849096032     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296478     Document Type: Article

References (9)

1. Beck O, Ryman T. Quantification of nitrendipine in plasma by a capillary column gas chromatographic - mass spectrometry method. J Chromatogr. 1985;337:402-408.
2. Pastera J, Mejstrikova L, Zoulova I, Macek K, Kvetina J. Simultaneous determination of nitrendipine and one of its metabolites in plasma samples by gas chromatography with electron-capture detection. J Pharm Biomed Anal. 2006;18:279-284.
3. Soons PA, Breimer DD. Gas chromatographic analysis of nitrendipine and its pyridine metabolite in human plasma. J Chromatogr. 1988;428:362-367.
4. Venishetty VK, Durairaj C, Sistla R, Yamsani MR, Diwan PV. Development and validation of a reversed-phase HPLC method for determination of nitrendipine in rat plasma: application to pharmacokinetic studies. Biomed Chromatogr. 2007;21:363-368.
5. Soo YO, Kwang YK, Yoon GK, Hyung-Gun Kim. High-performance liquid chromatographic analysis of nitrendipine in human plasma using ultraviolet detection and single-step solid-phase sample preparation. J Pharm Biomed Anal. 2003;32:387-392.
6. Marinkovic V, Agbaba D, Vladimirov S, Stankovic S. Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis. J Pharm Biomed Anal. 2001;24:993-998.
7. Baranda AB, Jiménez RM, Alonso RM. Simultaneous determination of five 1,4-dihydropyridines in pharmaceutical formulations by high-performance liquid chromatography-amperometric detection. J Chromatogr A. 2004,1031:275-280.
8. Chen XY, Zhong DF, Yang HY, Luan Y, Xu HY. Quantitative determination of nitrendipine and its metabolite dehydronitrendipine in human plasma using liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2001;15:518-524.
9. Baranda AB, Mueller CA, Alonso RM, Jimenez RM, Weinmann W. Quantitative determination of the calcium channel antagonists amlodipine, lercanidipine, nitrendipine, felodipine, and lacidipine in human plasma using liquid chromatography-tandem mass spectrometry. Ther Drug Monit. 2005;27:44-52.