Pharmacogenomics of methotrexate in rheumatoid arthritis: Does race make a difference?

Journal of Rheumatology

Volumn 35, Issue 4, 2008, Pages 550-552

  Dervieux, Thierry ^a  

^a Proprius Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHOTREXATE;

AFRICAN AMERICAN; ALLELE; EDITORIAL; ETHNICITY; GENE FREQUENCY; GENETIC RISK; GENETIC SCREENING; GENETIC TRAIT; GENETIC VARIABILITY; HUMAN; LIFESTYLE; MULTIFACTORIAL INHERITANCE; PHARMACOGENOMICS; PHENOTYPE; PRIORITY JOURNAL; RACE DIFFERENCE; RHEUMATOID ARTHRITIS; SCREENING TEST; SINGLE NUCLEOTIDE POLYMORPHISM;

ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CONTINENTAL POPULATION GROUPS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; METHOTREXATE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 41849088081     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (18)

1. van Ede AE, Laan RF, Blom HJ, et al. The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients. Arthritis Rheum 2001;44:2525-30.
2. Weisman MH, Furst DE, Park GS, et al. Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis. Arthritis Rheum 2006; 54:607-12.
3. Dervieux T, Furst D, Lein DO, et al. Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum 2004;50:2766-74.
4. Dervieux T, Greenstein N, Kremer J. Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis. Arthritis Rheum 2006;54:3095-103.
5. Wessels JA, de Vries-Bouwstra JK, Heijmans BT, et al. Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes. Arthritis Rheum 2006;54:1087-95.
6. Ranganathan P, Culverhouse R, Marsh S, et al. Methotrexate pathway gene polymorphisms and their effects on methotrexate toxicity in Caucasian and African American patients with rheumatoid arthritis. J Rheumatol 2008;35:572-90.
7. Ranganathan P, Culverhouse R, Marsh S, et al. Single nucleotide polymorphism profiling across the methotrexate pathway in normal subjects and patients with rheumatoid arthritis. Pharmacogenomics 2004;5:559-69.
8. Perry CA, Renna SA, Khitun E, Ortiz M, Moriarty DJ, Caudill MA. Ethnicity and race influence the folate status response to controlled folate intakes in young women. J Nutrition 2004;134:1786-92.
9. Alexander GR, Kogan M, Bader D, Carlo W, Allen M, Mor J. US birth weight/gestational age-specific neonatal mortality: 1995-1997 rates for Whites, Hispanics, and Blacks. Pediatrics 2003;111: e61-e66.
10. Gerhard GT, Malinow MR, DeLoughery TG, et al. Higher total homocysteine concentrations and lower folate concentrations in premenopausal black women than in premenopausal white women. Am J Clin Nutr 1999;70:252-60.
11. Jorde LB, Wooding SP Genetic variation, classification and 'race'. Nat Genet 2004;36 Suppl:S28-S33.
12. Lamason RL, Mohideen MA, Mest JR, et al. SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science 2005;310:1782-6.
13. Hughes LB, Beasley TM, Patel H, et al. Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis. Ann Rheum Dis 2006;65:1213-8.
14. Perna AF, Ingrooso D, De Santo NG. MTHFR C677T polymorphism and skin color: the white man's blackness [letter]. Kidney Int 2004;65:2444.
15. Rau T, Erney B, Gores R, Eschenhagen T, Beck J, Langer T. High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations. Clin Pharmacol Ther 2006;80:468-76.
16. Dervieux T, Kremer J, Lein DO, et al. Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis. Pharmacogenetics 2004;14:733-9.
17. Campalani E, Arenas M, Marinaki AM, Lewis CM, Barker JN, Smith CH. Polymorphisms in folate, pyrimidine, and purine metabolism are associated with efficacy and toxicity of methotrexate in psoriasis. J Invest Dermatol 2007;127:1860-7.
18. Wessels JA, Kooloos WM, de Jonge R, et al. Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis. Arthritis Rheum 2006;54:2830-9.