Molecular mapping of human hepatocellular carcinoma provides deeper biological insight from genomic data

European Journal of Cancer

Volumn 44, Issue 6, 2008, Pages 885-897

  Kittaka, Nobuyoshi ^a   Takemasa, Ichiro ^a   Takeda, Yutaka ^a   Marubashi, Shigeru ^a   Nagano, Hiroaki ^a   Umeshita, Koji ^a   Dono, Keizo ^a   Matsubara, Kenichi ^b   Matsuura, Nariaki ^a   Monden, Morito ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b DNA CHIP RESEARCH INC   (Japan)

Author keywords

'Hotspot' region; Biological insight; DNA microarray; Integrative method; Network analysis

Indexed keywords

GLYPICAN 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRIN; LIPOCORTIN 2; OSTEOPONTIN; PROTEIN KINASE B; PROTEIN S 100; S100 A10 PROTEIN; UNCLASSIFIED DRUG; VIMENTIN;

ADULT; AGED; ANALYTIC METHOD; ARTICLE; DISEASE MARKER; DNA MICROARRAY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE MAPPING; GENOMICS; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TUMOR GENE; UPREGULATION;

AGED; AGED, 80 AND OVER; ANNEXIN A2; CARCINOMA, HEPATOCELLULAR; CHROMOSOME MAPPING; DOWN-REGULATION; FEMALE; GENE EXPRESSION; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; S100 PROTEINS; UP-REGULATION;

EID: 41849087277     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2008.02.019     Document Type: Article

References (30)

1. Thomas M.B., and Abbruzzese J.L. Opportunities for targeted therapies in hepatocellular carcinoma. J Clin Oncol 23 (2005) 8093-8108
2. Jemal A., Murray T., Ward E., Samuels A., Tiwari R.C., and Ghafoor A. Cancer statistics, 2005. CA Cancer J Clin 55 (2005) 10-30
3. Pan H.W., Ou Y.H., Peng S.Y., Liu S.H., Lai P.L., and Lee P.H. Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma. Cancer 98 (2003) 119-127
4. Tsou A.P., Wu K.M., Tsen T.Y., Chi C.W., Chiu J.H., and Lui W.Y. Parallel hybridization analysis of multiple protein kinase genes: identification of gene expression patterns characteristic of human hepatocellular carcinoma. Genomics 50 (1998) 331-340
5. Schadt E.E., Monks S.A., Drake T.A., Lusis A.J., Che N., and Colinayo V. Genetics of gene expression surveyed in maize, mouse and man. Nature 422 (2003) 297-302
6. Brem R.B., Yvert G., Clinton R., and Kruglyak L. Genetic dissection of transcriptional regulation in budding yeast. Science 296 (2002) 752-755
7. Thorgeirsson S.S., and Grisham J.W. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 31 (2002) 339-346
8. Slaton J.W., Perrotte P., Inoue K., Dinney C.P., and Fidler I.J. Interferon-alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule. Clin Cancer Res 5 (1999) 2726-2734
9. Yamamoto T., Nagano H., Sakon M., Wada H., Eguchi H., and Kondo M. Partial contribution of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)/TRAIL receptor pathway to antitumor effects of interferon-alpha/5-fluorouracil against hepatocellular carcinoma. Clin Cancer Res 10 (2004) 7884-7895
10. Kondo M., Yamamoto H., Nagano H., Okami J., Ito Y., and Shimizu J. Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. Clin Cancer Res 5 (1999) 4005-4012
11. Capurro M., Wanless I.R., Sherman M., Deboer G., Shi W., and Miyoshi E. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology 125 (2003) 89-97
12. Zhang H., Ozaki I., Mizuta T., Yoshimura T., Matsuhashi S., and Hisatomi A. Mechanism of beta 1-integrin-mediated hepatoma cell growth involves p27 and S-phase kinase-associated protein 2. Hepatology 38 (2003) 305-313
13. Mottet D., Dumont V., Deccache Y., Demazy C., Ninane N., and Raes M. Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells. J Biol Chem 278 (2003) 31277-31285
14. Puisieux A., Ji J., and Ozturk M. Annexin II up-regulates cellular levels of p11 protein by a post-translational mechanisms. Biochem J 313 (1996) 51-55
15. Zobiack N., Gerke V., and Rescher U. Complex formation and submembranous localization of annexin 2 and S100A10 in live HepG2 cells. FEBS Lett 500 (2001) 137-140
16. Hollywood K., Brison D.R., and Goodacre R. Metabolomics: current technologies and future trends. Proteomics 6 (2006) 4716-4723
17. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 296 (2002) 1655-1657
18. Mootha V.K., Bunkenborg J., Olsen J.V., et al. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 (2003) 629-640
19. Ye Q.H., Qin L.X., Forgues M., He P., Kim J.W., and Peng A.C. Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med 9 (2003) 416-423
20. Hu D.D., Lin E.C., Kovach N.L., Hoyer J.R., and Smith J.W. A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5. J Biol Chem 270 (1995) 26232-26238
21. Song H.H., Shi W., and Filmus J. OCI-5/rat glypican-3 binds to fibroblast growth factor-2 but not to insulin-like growth factor-2. J Biol Chem 272 (1997) 7574-7577
22. Moorehead R.A., Sanchez O.H., Baldwin R.M., and Khokha R. Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma. Oncogene 22 (2003) 853-857
23. Regl G., Kasper M., Schnidar H., Eichberger T., Neill G.W., and Ikram M.S. The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells. Oncogene 23 (2004) 1263-1274
24. Apte U., Zeng G., Muller P., Tan X., Micsenyi A., and Cieply B. Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice. Hepatology 44 (2006) 992-1002
25. Gerke V., and Moss S.E. Annexins: from structure to function. Physiol Rev 82 (2002) 331-371
26. Yamada A., Irie K., Hirota T., Ooshio T., Fukuhara A., and Takai Y. Involvement of the annexin II-S100A10 complex in the formation of E-cadherin-based adherens junctions in Madin-Darby canine kidney cells. J Biol Chem 280 (2005) 6016-6027
27. Kovacs E.M., Ali R.G., McCormack A.J., and Yap A.S. E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts. J Biol Chem 277 (2002) 6708-6718
28. Siu M.K., Wong C.H., Lee W.M., and Cheng C.Y. Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases. J Biol Chem 280 (2005) 25029-25047
29. Abenoza P., Manivel J.C., Wick M.R., Hagen K., and Dehner L.P. Hepatoblastoma: an immunohistochemical and ultrastructural study. Hum Pathol 18 (1987) 1025-1035
30. Moinzadeh P., Breuhahn K., Stutzer H., and Schirmacher P. Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade-results of an explorative CGH meta-analysis. Br J Cancer 92 (2005) 935-941