Relationship between antioxidant potential and oxidative damage to lipids, proteins and DNA in aged rats

Physiological Research

Volumn 56, Issue 6, 2007, Pages 757-764

  Sivonova M ^a   Tatarkova Z ^a   Durackova Z ^b   Dobrota, D ^a   Lehotsky J ^a   Matakova T ^a   Kaplan P ^a  

^a University Teaching Hospital in Martin   (Slovakia)

^b Faculty of Medicine of Comenius University and University Hospital Bratislava   (Slovakia)

Author keywords

Aging; Antioxidant potential; Comet assay; Lipid peroxidation; Total sulfhydryl groups

Indexed keywords

6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID; ANTIOXIDANT; CHROMAN DERIVATIVE; DNA; PROTEIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL DERIVATIVE; TROLOX C; UNCLASSIFIED DRUG; URIC ACID;

AGING; ANIMAL; ARTICLE; BLOOD; COMET ASSAY; DRUG EFFECT; FLUORESCENCE MICROSCOPY; HEART; HEART MUSCLE; LIPID METABOLISM; LYMPHOCYTE; MALE; METABOLISM; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; RAT; WISTAR RAT;

AGING; ANIMALS; ANTIOXIDANTS; CHROMANS; COMET ASSAY; DNA; HEART; LIPID METABOLISM; LYMPHOCYTES; MALE; MICROSCOPY, FLUORESCENCE; MYOCARDIUM; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEINS; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; URIC ACID;

EID: 41749108701     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. ASHA DEVI S, PRATHIMA S, SUBRAMANYAM MV: Dietary vitamin E and physical exercise. II. Antioxidant status and lipofuscin-like substances in aging rat heart. Exp Gerontol 38: 291-297, 2003.
2. BEJMA J, RAMIRES P, LI LL: Free radical generation and oxidative stress with ageing and exercise: differential effects in the myocardium and liver. Acta Physiol Scand 169: 343-351, 2000.
3. BOUCHER F, TANGUY S, BESSE S, TRESALLET N, FAVIER A, DE LEIRIS J: Age-dependent changes in myocardial susceptibility to zero flow ischemia and reperfusion in isolated perfused rat hearts: relation to antioxidant status. Mech Ageing Dev 103: 301-316, 1998.
4. CAO G, GIOVANONI M, PRIOR RL: Antioxidant capacity decreases during growth but not aging in rat serum and brain. Arch Gerontol Geriatr 22: 27-37, 1996.
5. COLLINS A, DUŠINSKÁ M, GEDIK CM, ŠTETINA R: Oxidative damage to DNA: do we have a reliable biomarker? Environ Health Perspect 104: 465-469, 1996.
6. COLLINS A, DUŠINSKÁ M, FRANKLIN M, SOMOROVSKA M, PETROVSKA H, DUTHIE S, FILLION L, PANAYIOTIDIS M, RAŠLOVÁ K, VAUGHAN N: Comet assay in human biomonitoring studies: reliability, validation, and applications. Environ Mol Mutagen 30: 139-146, 1997.
7. EVELSON P, TRAVACIO M, REPETTO M, ESCOBAR J, LLESUY S, LISSI EA: Evaluation of total reactive antioxidant potential (TRAP) of tissue homogenates and their cytosols. Arch Biochem Biophys 15: 261-266, 2001.
8. FACINO RM, CARINI M, ALDINI G, BERTI F, ROSSONI G, BOMBARDELLI E, MORAZZONI P: Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischaemic damage in rats. Life Sci 64: 627-642, 1999.
9. GEDIK CM, EWEN SWB, COLLINS AR: Single-cell gel electrophoresis applied to the analysis of UV-C damage and its repair in human cells. Int J Radiat Biol 62: 313-320, 1992.
10. GEDIK CM, GRANT G, MORRICE PC, WOOD SGG, COLLINS AR: Effects of age and dietary restriction on oxidative DNA damage, antioxidant protection and DNA repair in rats. Eur J Nutr 44: 263-272, 2005.
11. GHISELLI A, SERAFINI M, MAIANI G, AZZINI E, FERRO-LUZZI A: A fluorescence-based method for measuring total plasma antioxidant capability. Free Radic Biol Med 18: 29-36, 1995.
12. GHISELLI A, SERAFINI M, NATELLA F, SCACCINI C: Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radic Biol Med 29: 1106-1114, 2000.
13. GOLDEN TR, HINERFELD DA, MELOV S: Oxidative stress and aging: beyond correlation. Aging Cell 1: 117-123, 2002.
14. HERNANZ A, FERNÁNDEZ-VIVANCOS E, MONTIEL C, VAZQUEZ JJ, ARNALICH F: Changes in the intracellular homocysteine and glutathione content associated with aging. Life Sci 67: 1317-1324, 2000.
15. HU ML: Measurement of protein thiol groups and glutathione in plasma. Methods Enzymol 233: 380-385, 1994.
16. ICIEK M, CHWATKO G, LORENC-KOCI E, BALD E, WLODEK L: Plasma levels of total, free and protein bound thiols as well as sulfane sulfur in different age groups of rats. Acta Biochim Pol 51: 815-824, 2004.
17. KAKARLA P, VADLURI G, REDDY KS, LEEUWENBURGH C: Vulnerability of the mid aged rat myocardium to the age-induced oxidative stress: influence of exercise training on antioxidant defense system. Free Radic Res 39: 1211-1217, 2005.
18. KALOUS M, DRAHOTA Z: The role of mitochondria in aging. Physiol Res 45: 351-359, 1996.
19. KAMZALOV S, SOHAL RS: Effect of age and caloric restriction on coenzyme Q and alpha-tocopherol levels in the rat. Exp Gerontol 39: 1199-1205, 2004.
20. KIM JW, NO JK, IKENO Y, YU BP, CHOI JS, YOKOZAWA T, CHUNG HY: Age-related changes in redox status of rat serum. Arch Gerontol Geriatr 34: 9-17, 2002.
21. KOHEN R, NYSKA A: Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol 30: 620-650, 2002.
22. KRAJČOVIČOVÁ-KUDLÁČKOVÁ M, DUŠINSKÁ M, VALACHOVIČOVÁ M, BLAŽÍ ČEK P, PAUKOVÁ V: Products of DNA, protein and lipid oxidative damage in relation to vitamin C plasma concentration. Physiol Res 55: 227-231, 2006.
23. LOWRY OH, ROSEBROUGH NJ, FARR AL, RANDALL RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275, 1951.
24. NAKAMURA YK, OMAYE ST: Age-related changes of serum lipoprotein oxidation in rats. Life Sci 23: 1265-1275, 2004.
25. PRIOR RL, CAO G: In vivo total antioxidant capacity: comparison of different analytical methods. Free Radic Biol Med 27: 1173-1181, 1999.
26. QUILES JL, OCHOA JL, RAMIREZ-TORTOSA C, BATTINO M, HUERTAS JR, MARTÍN Y, MATAIX J: Dietary fat type (virgin olive vs. sunflower oils) affects age-related changes in DNA double-strand-breaks, antioxidant capacity and blood lipids in rats. Exp Gerontol 39: 1189-1198, 2004.
27. RODRIGUES SIQUEIRA I, FOCHESATTA C, da SILVA TORRES IL, DALMAZ C, ALEXANDRE NETTO C: Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats. Life Sci 78: 271-278, 2005.
28. SAIČIĆ ZS, MIJALKOVIĆ DN, NIKOLIĆ AL, BLAGOJEVIĆ DP, SPASIĆ MB: Effect of thyroxine on antioxidant defense system in the liver of rats of different age. Physiol Res 55: 561-568, 2006.
29. SOBOČANEC S, BALOG T, ŠVERKO V, MAROTTI T: Met-enkephalin modulation of age-related changes in red cell antioxidant status. Physiol Res 54: 97-104, 2005.
30. STOCKER R, KEANEY JF: Role of oxidative modifications in atherosclerosis. Physiol Rev 84: 1381-1478, 2004.
31. SZWEDA PA, CAMOUSE M, LUNBERG KC, OBERLEY TD, SZWEDA LI: Aging, lipofuscin formation, and free radical-mediated inhibition of cellular proteolytic systems. Ageing Res Rev 2: 383-405, 2003.
32. TATARKOVÁ Z, KAPLÁN P, MATEJOVIČOVÁ M, LEHOTSKÝ J, DOBROTA D, FLAMENG W: Effect of ischemia and reperfusion on protein oxidation in isolated rabbit hearts. Physiol Res 54: 185-191, 2005.
33. THOMAS JA, MALLIS RJ: Aging and oxidation of reactive protein sulfhydryls. Exp Gerontol 36: 1519-1526, 2001.
34. UMEGAKI K, HASHIMOTO M, YAMASAKI H, FUJII Y, YOSHIMURA M, SUGISAWA A, SHINOZUKA K: Docosahexaenoic acid supplementation-increased oxidative damage in bone marrow DNA in aged rats and its relation to antioxidant vitamins. Free Radic Res 34: 427-435, 2001.
35. VAN DER LOO B, BACHSCHMID M, SPITZER V, BREY L, ULLRICH V, LÜSCHER TF: Decreased plasma and tissue levels of vitamin C in a rat model of aging: implications for antioxidative defense. Biochem Biophys Res Commun 303: 483-487, 2003.
36. VAN DER LOO B, LABUGGER R, AEBISCHER CP, BACHSCHMID M, SPITZER V, KILO J, ALTWEGG L, ULLRICH V, LÜSCHER TF: Age-related changes of vitamin A status. J Cardiovasc Pharmacol 43: 26-30, 2004.
37. VAN REMMEN H, RICHARDSON A: Oxidative damage to mitochondria and aging. Exp Gerontol 36: 957-968, 2001.
38. VASSALLE C, PETROZZI L, BOTTO N, ANDREASSI MG, ZUCCHELLI GC: Oxidative stress and its association with coronary artery disease and different atherogenic risk factors. J Intern Med 256: 308-315, 2004.
39. WOLF FI, FASANELLA S, TEDESCO B, CAVALLINI G, DONATI A, BERGAMINI E, CITTADINI A: Peripheral lymphocyte 8-OHdG levels correlate with age-associated increase of tissue oxidative DNA damage in Sprague-Dawley rats. Protective effects of caloric restriction. Exp Gerontol 40: 181-188, 2005.