Effect of buffer solution and temperature on the stability of penicillin G

Journal of Chemical and Engineering Data

Volumn 53, Issue 2, 2008, Pages 543-547

  Lu, Xinbo ^a   Xing, Huabin ^a   Su, Baogen ^a   Ren, Qilong ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PH EFFECTS; SODIUM; STABILITY; THERMAL EFFECTS;

ARRHENIUS EQUATIONS; BUFFER SOLUTIONS; MOLAR RATIOS;

ANTIBIOTICS;

EID: 41749102228     PISSN: 00219568     EISSN: None     Source Type: Journal    
DOI: 10.1021/je7006378     Document Type: Article

References (21)

1. Wright, A. J. The penicillins. Mayo Clin. Proc. 1999, 74, 290-307.
2. Bundgaard, H. Kinetic demonstration of a metastable intermediate in isomerization of penicillin to penicillenic acid in aqueous solution. J. Pharm. Sci. 1971, 60, 1273-1275.
3. Kessler, D. P.; Ghebre-Sellassie, I.; Knevel, A. M.; Hem, S. L. A kinetic analysis of the acidic degradation of penicillin G and confirmation of penicillamine as a degradation product. J. Chem. Soc., Perkin Trans. 1981, II, 1247-1251.
4. Frau, J.; Donoso, J.; Muñoz, F.; García Blanco, F. Semiempirical calculations of the hydrolysis of Penicillin G. J. Mol. Struct. 1997, 390, 255-263.
5. Ghassempour, A.; Vaezi, F.; Salehpour, P.; Nasiri-Aghdam, M.; Adrangui, M. Monitoring of enzymatic hydrolysis of penicillin G by pyrolysis-negative ion mass spectrometry. J. Pharm. Biomed. Anal. 2002, 29, 569-578.
6. Tayal, J. N.; Nanda, J. N. Stability of benzylpenicillin. Labdev. 1964, 2, 1-7.
7. Neftel, K. A.; Wälti, M.; Spengler, H.; de Weck, A. L. Effect of storage of penicillin-G solutions on sensitisation to penicillin-G after intravenous administration. Lancet 1982, 1, 986-988.
8. Pulvertaft, R. J. V.; Yudkin, J. Stabilization of penicillin solutions with phosphate. Lancet 1946, 251, 265-267.
9. Brodersen, R. Stability of penicillin G in aqueous solution as a function of hydrogen ion concentration and temperature. Acta Pharmacol. Toxicol. 1947, 3, 345-363.
10. Hahn, L. Stabilization of penicillin solutions with sodium citrate. Lancet 1947, 252, 408-410.
11. Lindsay, R. E.; Hem, S. L. Effect of ionic strength on chemical stability of potassium penicillin G. J. Pharm. Sci. 1972, 61, 202-206.
12. Tsuji, A.; Matsuda, M.; Miyamoto, E.; Yamana, T. Effect of surfactants on degradation of penicllins and cephalosporins in acidic medium. J. Pharm. Pharmacol. 1978, 30, 442-444.
13. Ong, J. K.; Sunderland, V. B.; McDonald, C. Influence of hydroxypropyl beta-cyclodextrin on the stability of benzylpenicillin in chloroacetate buffer. J. Pharm. Pharmacol. 1997, 49, 617-621.
14. Zhao, Q.; Zhan, X. C.; Li, L. L.; Li, C. R.; Lin, T.; Yin, X. D.; He, N. Programmed humidifying in Drug stability experiments. J. Pharm. Sci. 2005, 94, 2531-2540.
15. Das Gupta, V.; Stewart, K. R. pH-Dependent effect of magnesium sulfate on the stability of penicillin G potassium solution. Am. J. Hosp. Pharm. 1985, 42, 598-602.
16. Michnik, A.; Michalik, K.; Marcoin, W. Influence of magnesium glutamate on stability of penicillin G aqueous solution. Int. J. Pharm. 2004, 273, 149-158.
17. Ballereau, F.; Prazuck, T.; Schrive, I.; Lafleuriel, M. T.; Rozec, D.; Fisch, A.; Lafaix, C. Stability of essential drugs in the field: Results of a study conducted over a two-year period in Burkina Faso. Am. J. Trop. Med. Hyg. 1997, 57, 31-36.
18. European pharmacopoeia, 2005; 5.0, pp 1082-1083.
19. Kheirolomoom, A.; Kazemi-Vaysari, A.; Ardjmand, M.; Baradar-Khoshfetrat, A. The combined effects of pH and temperature on penicillin G decomposition and its stability modeling. Process Biochem. 1999, 35, 205-211.
20. Mitsumori, F.; Arata, Y.; Fujiwara, S.; Muranaka, M.; Horiuchi, Y. NMR study of spontaneous degradation of penicillin G in aqueous solution. Bull. Chem. Soc. Jpn. 1977, 50, 3164-3166.
21. Jemal, M.; Hem, S. L.; Knevel, A. M. Demonstration of penicillamine as a product in benzylpenicillenic acid degradation in neutral media using differential pulse polarography. J. Pharm. Sci. 1978, 67, 302-305.