Regulation of caveolar cardiac sodium current by a single G sα histidine residue

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 4, 2008, Pages

  Palygin, Oleg A ^a   Pettus, Janette M ^a   Shibata, Erwin F ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Caveolae; Caveolin; G protein; Ventricle; Voltage gated sodium channel subunit 1.5

Indexed keywords

ALANINE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CAVEOLIN 3; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HISTIDINE; PROTEIN ANTIBODY; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CAVEOLA; CELL MEMBRANE; CONTROLLED STUDY; HEART MUSCLE CELL; HEART VENTRICLE; MALE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; SODIUM CURRENT; VOLTAGE CLAMP;

ADRENERGIC BETA-AGONISTS; ANIMALS; CAVEOLAE; CAVEOLIN 3; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HISTIDINE; ION CHANNEL GATING; ISOPROTERENOL; MALE; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA; SODIUM; SODIUM CHANNELS;

EID: 41749098073     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01337.2007     Document Type: Article

References (34)

1. Alpert L, Fozzard H, Hanck D, Makielski J. Is there a second external lidocaine binding site on mammalian cardiac cells? Am J Physiol Heart Circ Physiol 257: H79-H84, 1989.
2. 2-adrenergic regulation. Proc Natl Acad Sci USA 103: 7500-7505, 2006.
3. Barouch L, Harrison R, Skaf M, Rosas G, Cappola T, Kobeissi Z, Hobal I, Lemmon C, Burnett A, O'Rourke B, Rodriguez E, Huang P, Lima J, Berkowitz D, Hare J. Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature 416: 337-340, 2002.
4. Bucci M, Gratton JP, Rudic R, Acevedo L, Roviezzo F, Cirino G, Sessa W. In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Nat Med 6: 1362-1367, 2000.
5. Carozzi A, Roy S, Morrow I, Pol A, Wyse B, Clyde-Smith J, Prior I, Nixon S, Hancock J, Parton R. Inhibition of lipid raft-dependent signaling by a dystrophy-associated mutant of caveolin-3. J Biol Chem 277: 17944-17949, 2002.
6. Cohen A, Hnasko R, Schubert W, Lisanti M. Role of caveolae and caveolins in health and disease. Physiol Rev 84: 1341-1379, 2004.
7. Couet J, Li S, Okamoto T, Ikezu T, Lisanti MP. Identification of peptide and protein ligands for the caveolin-scaffolding domain. J Biol Chem 272: 6525-6533, 1997.
8. DeLano W. The PyMol Molecular Graphics System. Palo Alto, CA: Delano Scientific, 2002.
9. Folco E, Liu GX, Koren G. Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5. Am J Physiol Heart Circ Physiol 287: H681-H690, 2004.
10. Frohnwieser B, Chen LQ, Schreibmayer W, Kallen R. Modulation of the human cardiac sodium channel α-subunit by cAMP-dependent protein kinase and the responsible sequence domain. J Physiol 498: 309-318, 1997.
11. Head B, Patel H, Roth D, Lai N, Niesman I, Farquhar M, Insel P. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3 microdomains in adult cardiac myocytes. J Biol Chem 280: 31036-31044, 2005.
12. Insel P, Head B, Ostrom R, Patel H, Swaney J, Tang CM, Roth D. Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes. Ann NY Acad Sci 1047: 166-172, 2005.
13. Kawabe JI, Grant BS, Yamamoto M, Schwencke C, Okumura S, Ishikawa Y. Changes in caveolin subtype protein expression in aging rat organs. Mol Cell Endocrinol 176: 91-95, 2001.
14. Li S, Okamoto T, Chun M, Sargiacomo M, Casanova J, Hansen S, Nishimoto I, Lisanti M. Evidence for a regulated interaction between heterotrimeric G proteins and caveolin. J Biol Chem 270: 15693-15701, 1995.
15. Lu T, Lee HC, Kabat J, Shibata E. Modulation of rat cardiac sodium channel by the stimulatory G-protein α-subunit. J Physiol 518: 371-384, 1999.
16. Maguy A, Herbert T, Nattel S. Involvement of lipid rafts and caveolae in cardiac channel function. Cardiovasc Res 69: 798-807, 2006.
17. Matsuda J, Lee HC, Shibata E. Enhancement of rabbit cardiac sodium channels by β-adrenergic stimulation. Circ Res 70: 199-207, 1992.
18. Melchior N. Sodium and potassium complexes of adenosine- triphosphate: equilibrium studies. J Biol Chem 208: 615-627, 1954.
19. Oh P, Schnitzer J. Segregation of heterotrimeric G proteins in cell surface microdomains: Gq binds caveolin to concentrate in caveolae, whereas Gi and Gs target lipid rafts by default. Mol Biol Cell 12: 685-698, 2001.
20. Okamoto T, Schlegel A, Scherer P, Lisanti M. Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J Biol Chem 273: 5419-5422, 1996.
21. Ono K, Fozzard H, Hanck D. Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics. Circ Res 72: 807-815, 1993.
22. Parton R, Simon K. The multiple faces of caveolae. Nat Rev Mol Cell Biol 8: 185-194, 2007.
23. Patel H, Murray F, Insel P. Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu Rev Pharmacol Toxicol 48: 14.11-14.33, 2007.
24. Razani B, Lisanti M. Caveolins and caveolae: molecular and functional relationships. Exp Cell Res 271: 36-44, 2001.
25. Razani B, Woodman S, Lisanti M. Caveolae: from cell biology to animal physiology. Pharmacol Rev 54: 431-446, 2002.
26. Rybin V, Xu X, Steinberg S. Activated protein kinase C isoform targets to cardiomyocyte caveolae: stimulation of local protein phosphorylation. Circ Res 84: 980-988, 1999.
27. Scriven D, Klimek A, Asghari P, Bellve K, Moore E. Caveolin-3 is adjacent to a group of extradyadic ryanodine receptors. Biophys J 89: 1893-1901, 2005.
28. Shibata E, Brown T, Washburn Z, Bai J, Revak T, Butters C. Autonomic regulation of voltage-gated cardiac ion channels. J Cardiovasc Electrophysiol 17: S34-S42, 2006.
29. Smart E, Ying Y, Mineo C, Anderson R. A detergent-free method for purifying caveolae membrane from tissue culture cells. Proc Natl Acad Sci USA 92: 10104-10108, 1995.
30. Sunahara R, Tesmer J, Gilman A, Sprang S. Crystal structure of the adenylyl cyclase activator Gsα. Science 278: 1943-1947, 1997.
31. Van Deurs B, Roepstorff K, Hommelgaard A, Sandvig K. Caveolae: anchored, multifunctional platforms in the lipid ocean. Trends Cell Biol 13: 92-100, 2003.
32. Wilson J, Chin A. Chelation of divalent cations by ATP, studied by titration calorimetry. Anal Biochem 193: 16-19, 1991.
33. Yarbrough T, Lu T, Lee HC, Shibata E. Localization of cardiac sodium channels in caveolin-rich membrane domains: regulation of sodium current amplitude. Circ Res 90: 443-449, 2002.
34. Zhou H, Yi J, Hu N, George A Jr, Murray K. Activation of protein kinase A modulates trafficking of the human cardiac sodium channel in Xenopus oocytes. Circ Res 87: 33-38, 2000.