A case report of recurrent vascular access thrombosis in a hemodialysis patient reveals combined acquired and inherited thrombophilia

Therapeutic Apheresis and Dialysis

Volumn 12, Issue 2, 2008, Pages 190-192

  Eleftheriadis, Theodoros ^a   Antoniadi, Georgia ^a   Akritidou, Aliki ^a   Kasimatis, Efstratios ^a   Apostolidis, Georgios ^a   Pashalidou, Sonia ^a   Salmas, Marios ^a   Liakopoulos, Vassilis ^a   Barboutis, Konstantinos ^a  

^a General District Hospital of Serres   (Greece)

Author keywords

Anticoagulants; Factor V; Factor VIII; Hemodialysis; Thrombophilia; Vascular access thrombosis

Indexed keywords

ACTIVATED PROTEIN C; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 5 LEIDEN; BLOOD CLOTTING FACTOR 8; CALCIUM CARBONATE; FOLIC ACID; PROTHROMBIN; RECOMBINANT ERYTHROPOIETIN; TICLOPIDINE; TINZAPARIN; WARFARIN;

ACQUIRED THROMBOPHILIA; ACTIVATED PROTEIN C RESISTANCE; ADULT; ALPORT SYNDROME; ANTICOAGULANT THERAPY; ARTERIOVENOUS FISTULA; ARTICLE; BLOOD FLOW; CASE REPORT; CAUCASIAN; FATALITY; HEMODIALYSIS; HETEROZYGOSITY; HUMAN; INHERITED THROMBOPHILIA; INTERNATIONAL NORMALIZED RATIO; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECURRENT DISEASE; THROMBOPHILIA; THROMBOSIS; TREATMENT OUTCOME; VASCULAR ACCESS;

ADULT; ANTICOAGULANTS; ARTERIOVENOUS SHUNT, SURGICAL; FACTOR V; FACTOR VIII; HUMANS; MALE; NEPHRITIS, HEREDITARY; RENAL DIALYSIS; THROMBOPHILIA; THROMBOSIS; WARFARIN;

EID: 41749095877     PISSN: 17449979     EISSN: 17449987     Source Type: Journal    
DOI: 10.1111/j.1744-9987.2008.00569.x     Document Type: Article

References (14)

1. Feldman HI, Kobrin S, Wasserstein A. Hemodialysis vascular access morbidity. J Am Soc Nephrol 1996 7 : 523 35.
2. Smits JH, van der Linden J, Blankestijn PJ, Rabelink TJ. Coagulation and haemodialysis access thrombosis. Nephrol Dial Transplant 2000 15 : 1755 60.
3. Girndt M, Heine GH, Ulrich C, Kohler H DialGene Consortium. Gene polymorphism association studies in dialysis: vascular access. Semin Dial 2007 20 : 63 7.
4. Ridker PM, Miletich JP, Hennekens CH, Buring JE. Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening. JAMA 1997 277 : 1305 7.
5. Rosendaal FR, Doggen CJ, Zivelin A et al. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998 79 : 706 8.
6. Thorelli E, Kaufman RJ, Dahlback B. Cleavage of factor V at Arg 506 by activated protein C and the expression of anticoagulant activity of factor V. Blood 1999 93 : 2552 8.
7. Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 1995 85 : 1504 8.
8. Fodinger M, Mannhalter C, Pabinger I. Resistance to activated protein C (APC): mutation at Arg506 of coagulation factor V and vascular access thrombosis in haemodialysis patients. Nephrol Dial Transplant 1996 11 : 668 72.
9. Akman B, Afsar B, Atac FB et al. Predictors of vascular access thrombosis among patients on the cadaveric renal transplantation waiting list. Transplant Proc 2006 38 : 413 15.
10. Knoll GA, Wells PS, Young D et al. Thrombophilia and the risk for hemodialysis vascular access thrombosis. J Am Soc Nephrol 2005 16 : 1108 14.
11. Wegmuller E, Gruninger U, Furlan M, Beck EA, Hodler J, Reubi FC. Factor VIII activity in chronic renal disease. Nephron 1981 28 : 157 62.
12. O'shea SI, Lawson JH, Reddan D, Murphy M, Ortel TL. Hypercoagulable states and antithrombotic strategies in recurrent vascular access site thrombosis. J Vasc Surg 2003 38 : 541 8.
13. Molino D, De Santo NG, Marotta R, Anastasio P, Mosavat M, De Lucia D. Plasma levels of plasminogen activator inhibitor type 1, factor VIII, prothrombin activation fragment 1+2, anticardiolipin, and antiprothrombin antibodies are risk factors for thrombosis in hemodialysis patients. Semin Nephrol 2004 24 : 495 501.
14. Kamphuisen PW, Eikenboom JC, Rosendaal FR et al. High factor VIII antigen levels increase the risk of venous thrombosis but are not associated with polymorphisms in the von Willebrand factor and factor VIII gene. Br J Haematol 2001 115 : 156 8.