Promotion potential of madder color in a medium-term multi-organ carcinogenesis bioassay model in F344 rats

Journal of Food Science

Volumn 73, Issue 3, 2008, Pages

  Yokohira, M ^a   Yamakawa, K ^a   Hosokawa, K ^a   Matsuda, Y ^a   Kuno, T ^a   Saoo, K ^a   Imaida, K ^a  

^a KAGAWA UNIVERSITY   (Japan)

Author keywords

Food additive; Kidney; Liver; Madder color; Medium term multi organ bioassay

Indexed keywords

CARCINOGEN; MADDER COLOR; PLANT EXTRACT; UNCLASSIFIED DRUG;

ADENOMA; ANIMAL; ARTICLE; BIOASSAY; CARCINOGEN TESTING; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; EXPERIMENTAL NEOPLASM; FISCHER 344 RAT; KIDNEY TUMOR; LIVER TUMOR; MALE; PATHOLOGY; RANDOMIZATION; RAT; RUBIA;

ADENOMA; ANIMALS; BIOLOGICAL ASSAY; CARCINOGENICITY TESTS; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; KIDNEY NEOPLASMS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; NEOPLASMS, EXPERIMENTAL; PLANT EXTRACTS; RANDOM ALLOCATION; RATS; RATS, INBRED F344; RUBIA;

ANIMALIA; RATTUS; RUBIA TINCTORUM;

EID: 41749084614     PISSN: 00221147     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2008.00685.x     Document Type: Article

References (19)

1. Asanoma M, Miyabe M, Sakabe Y. 1984. Mutagenicity of natural food additives in Salmonella typhimurium(II). Nagoyasi Eisei Kenkyuuhou 30 : 53 7.
2. Brown JP, Brown RJ. 1976. Mutagenesis by 9,10-anthraquinone derivatives and related compounds in Salmonella typhimurium. Mutat Res 40 (3 203 24.
3. Derksen GC, Niederlander HA, van Beek TA. 2002. Analysis of anthraquinones in Rubia tinctorum L. by liquid chromatography coupled with diode-array UV and mass spectrometric detection. J Chromatogr A 978 (1-2 119 27.
4. Derksen GC, Naayer M, van Beek TA, Capelle A, Haaksman IK, van Doren HA, de Groot A. 2003. Chemical and enzymatic hydrolysis of anthraquinone glycosides from madder roots. Phytochem Anal 14 (3 137 44.
5. Derksen GC, Lelyveld GP, van Beek TA, Capelle A, de Groot AE. 2004. Two validated HPLC methods for the quantification of alizarin and other anthraquinones in Rubia tinctorum cultivars. Phytochem Anal 15 (6 397 406.
6. Gary AB, Scot LE, Michel RE, Charles AM, William FM. 1990. Pathology of the Fischer Rat. San Diego, Calif. : Academic Press.
7. Hagiwara A, Kawabe M, Tanaka H, Kokubo Y, Sano M, Tamano S, Kadota T, Nakamura M, Imaida K. 1997. Two different constituents of madder color lack tumor promoting or carcinogenic potential in a medium-term multi-organ carcinogenesis bioassay in rats. Jpn J Food Chem 4 (2 99 106.
8. International Agency for Research on Cancer [IARC]. 2002. IARC monograph on the evaluation of carcinogenic risks to humans. Some traditional herbal medicines, some mycotoxins, naphthalene and styrene. 82 : 129 51.
9. Ito N, Imaida K, Hirose M, Shirai T. 1998. Medium-term bioassays for carcinogenicity of chemical mixtures. Environ Health Perspect 106 (Suppl 6 1331 6.
10. Ito N, Imaida K, Asamoto M, Shirai T. 2000. Early detection of carcinogenic substances and modifiers in rats. Mutat Res 462 (2-3 209 17.
11. Kawasaki Y, Goda Y, Yoshihira K. 1992. The mutagenic constituents of Rubia tinctorum. Chem Pharm Bull (Tokyo) 40 (6 1504 9.
12. Masutomi N, Shibutani M, Toyoda K, Niho N, Uneyama C, Hirose M. 2000. A 90-day repeated dose toxicity study of madder color in F344 rats: a preliminary study for chronic toxicity and carcinogenicity studies. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku (118 55 62. In Japanese.
13. Mohr U, Greaves P, Ito N, Capen CC, JFH, Long PH, Dungworth DL, Hayashi Y, Lringle G. 2001. International Classification of rodent tumors: the mouse. Berlin : Springer.
14. Shibutani M, Inoue K, Li K, Morikawa A, Hirose M. 2004. Combined chronic toxicity/carcinogenic test (progress report). Natl. Inst. of Health Sciences in Japan, 18 June 2004.
15. Shirai T, Hirose M, Ito N. 1999. Medium-term bioassays in rats for rapid detection of the carcinogenic potential of chemicals. IARC Sci Publ (146 251 72.
16. Tananka T, Ino N, Okumura A, Makita H, Mori H. 1994. Acute and subacute toxicity study of madder root, new natural colors, derived from Rubia tinctorum. Jpn J Food Chem 1 : 17 21.
17. Watanabe T, Katsura Y, AY. 1994. Image processors for analytical pathology. J Toxicol Pathol 7 : 353 61.
18. Westendorf J, Poginsky B, Marquardt H, Groth G, Marquardt H. 1988. The genotoxicity of lucidin, a natural component of Rubia tinctorum L., and lucidinethylether, a component of ethanolic Rubia extracts. Cell Biol Toxicol 4 (2 225 39.
19. Yasui Y, Takeda N. 1983. Identification of a mutagenic substance, in Rubia tinctorum L. (madder) root, as lucidin. Mutat Res 121 (3-4 185 90.