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CuTC promotes many coupling reactions very effectively and often demonstrates unique reactivities. See: a
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41649114628
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For isolated literature examples of halogen-selective Suzuki couplings between 1,2-dihalobenzenes and α-hydroxyphenylboronic acid derivatives, see: (a) Buchwald, S. L.; Huang, X.; Zim, D. PCT Int. Appl. WO 2004/052939, 2004.
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For isolated literature examples of halogen-selective Suzuki couplings between 1,2-dihalobenzenes and α-hydroxyphenylboronic acid derivatives, see: (a) Buchwald, S. L.; Huang, X.; Zim, D. PCT Int. Appl. WO 2004/052939, 2004.
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The Suzuki coupling between 2,3-dichloroquinoxaline and α-methoxyphenylboronic acid has been reported: Mao, L.; Sakurai, H.; Hirao, T. Synthesis 2004, 2535-2539.
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The Suzuki coupling between 2,3-dichloroquinoxaline and α-methoxyphenylboronic acid has been reported: Mao, L.; Sakurai, H.; Hirao, T. Synthesis 2004, 2535-2539.
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39
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33746659068
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41649119427
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It should be noted that if a routine aqueous extractive workup were employed, a heavy emulsion would often form due to the formation of insoluble Cu complex, which could result in product loss. The use of aqueous HCl or EDTA/NaOH solution, for non-basic and basic substrates, respectively, significantly alleviates and often eliminates this problem
-
It should be noted that if a routine aqueous extractive workup were employed, a heavy emulsion would often form due to the formation of insoluble Cu complex, which could result in product loss. The use of aqueous HCl or EDTA/NaOH solution, for non-basic and basic substrates, respectively, significantly alleviates and often eliminates this problem.
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