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Aletaha D, Funovits J, Keystone EC, Smolen JS. Disease activity early in the course of treatment predicts response to therapy after one year in rheumatoid arthritis patients. Arthritis Rheum 2007; 56:3226-3235. Ttreatment response at 3-6 months from start of therapy is highly predictive of the response at endpoint (1 year), irrespective of the type of therapy. This indicates that therapies that are ineffective in terms of reaching low disease activity within 3-6 months should be discontinued and other treatment options employed.
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