Latent hypoparathyroidism in an osteoporotic patient with multiple endocrinopathies and secondary hemochromatosis due to multiple blood transfusions, unmasked by alendronate and glucocorticoid at adrenal crisis

Internal Medicine

Volumn 47, Issue 6, 2008, Pages 515-520

  Tanimoto, Keiji ^a   Okubo, Yumiko ^a   Harada, Chie ^a   Saito, Hiroshi ^a   Sata, Akira ^a   Nishikawa, Aiko ^a   Ohwada, Rina ^a   Tsuiki, Mika ^a   Yamamoto, Masaaki ^a   Hashimoto, Etsuko ^a   Sato, Kanji ^a   Takano, Kazue ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Bisphosphonate; Blood transfusion; Hypocalcemia; Hypoparathyroidism; Secondary hemochromatosis

Indexed keywords

ALENDRONIC ACID; ALFACALCIDOL; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; CEFCAPENE PIVOXIL; GLUCOCORTICOID; HYDROCORTISONE; HYDROCORTISONE SODIUM SUCCINATE; INSULIN; LEVOTHYROXINE; OFLOXACIN; PARATHYROID HORMONE; SODIUM CHLORIDE; TESTOSTERONE ENANTATE; BONE DENSITY CONSERVATION AGENT;

ADRENAL CORTEX INSUFFICIENCY; ADULT; ANOREXIA; ARTICLE; BLOOD TRANSFUSION; BONE MARROW TRANSPLANTATION; CALCIUM BLOOD LEVEL; CASE REPORT; DIABETES MELLITUS; DIAGNOSTIC IMAGING; DRUG WITHDRAWAL; FRACTURE; HEMOCHROMATOSIS; HOSPITAL ADMISSION; HUMAN; HYPOCALCEMIA; HYPOGONADISM; HYPOPARATHYROIDISM; HYPOPITUITARISM; LABORATORY TEST; MALAISE; MALE; OSTEOPOROSIS; PATIENT COMPLIANCE; PHYSICAL EXAMINATION; POLYENDOCRINOPATHY; PRESCRIPTION; SECONDARY HYPERPARATHYROIDISM; ADRENAL GLAND; BLOOD; ENDOCRINE DISEASE; METABOLISM; OSTEOLYSIS;

ADRENAL GLANDS; ADULT; ALENDRONATE; BLOOD TRANSFUSION; BONE DENSITY CONSERVATION AGENTS; BONE RESORPTION; CALCIUM; DIABETES MELLITUS; ENDOCRINE SYSTEM DISEASES; GLUCOCORTICOIDS; HEMOCHROMATOSIS; HUMANS; HYPOGONADISM; HYPOPARATHYROIDISM; HYPOPITUITARISM; MALE; OSTEOPOROSIS; PARATHYROID HORMONE;

EID: 41649118094     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.47.0642     Document Type: Article

References (29)

1. Goltzman D, Cole DEC. Hypoparathyriodism. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Fifth edition. Favus MJ, Ed. American Society for Bone and Mineral Research, Washington, D.C., 2003: 274-278.
2. Even L, Bader T, Hochberg Z. Nocturnal calcium, phosphorus and parathyroid hormone in the diagnosis of concealed and subclinical hypoparathyroidism. Eur J Endocnrinol 156: 113-116, 2007.
3. MacDonald RA, Mallory GK. Hemochromatosis and hemosiderosis. Study of 211 autopsied cases. Arch Intem Med 105: 686-700, 1960.
4. 3. Am J Med Sci 276: 363-368, 1978.
5. Shirota T, Shinoda T, Aizawa T, et al. Primary hypothyroidism and multiple endocrine failure in association with hemochromatosis in a longterm hemodialysis patient. Clin Nephrol 38: 105-109, 1992.
6. Himoto Y, Kanzaki S, Nomura H, Araki T, Takahashi Y, Seino Y. Hypothyroidism and hypoparathyroidism in an 11 year old boy with hemochromatosis secondary to aplastic anemia. Acta Paediatr Jpn 37: 534-536, 1995.
7. Lanes R, Muller A, Palacios A. Multiple endocrine abnormalities in a child with Blackfan-Diamond anemia and hemochromatosis. Significant improvement of growth velocity and predicted adult height following growth hormone treatment despite liver damage. J Pediatr Endocrinol Metab 13: 325-328, 2000.
8. Chem JP, Lin KH. Hypoparathyroidism in transfusion-dependent patients with beta-thalassemia. J Pediatr Hematol Oncol 24: 291-293, 2002.
9. Angelopoulos NG, Goula A, Rombopoulos G, et al. Hypoparathyroidism in transfusion-dependent patients with beta-thalassemia. J Bone Miner Metab 24: 138-145, 2006.
10. Russell RG, Rogers MJ, Frith JC, et al. The pharmacology of bisphosphonates and new insights into their mechanisms of action. J Bone Miner Res 14 (Suppl 2): 53-65, 1999.
11. Lukert B. Glucocorticoid-induced osteoporosis. In: Osteoporosis. Marcus R, Feldman D, Kelsey J, Eds. Academic Press, New York 1996: 801-820.
12. Noma S, Konishi J, Morikawa M, Yoshida Y. MR imaging of thyroid hemochromatosis. J Comput Assist Tomogr 12: 623-625, 1988.
13. Álústiza JM, Artetxe J, Castiella A, et al. Gipuzkoa Hepatic Iron Concentration by MRI Study Group. MR quantification of hepatic iron concentration. Radiology 230: 479-484, 2004.
14. Martin DR, Semelka RC. Magnetic resonance imaging of the liver: review of techniques and approach to common diseases. Semin Ultrasound CT MR 26: 116-131, 2005.
15. Christoforidis A, Haritandi A, Tsitouridis I, et al. Correlative study of iron accumulation in liver, myocardium, and pituitary assessed with MRI in young thalassemic patients. J Pediatr Hematol Oncol 28: 311-315, 2006.
16. Portale AA. Blood calcium, phosphorus, and magnesium. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Fifth edition. Favus MJ, Ed. American Society for Bone and Mineral Research, Washington, D.C., 2003: 151-154.
17. Jandl JH. Hypochromic anemia and diorders of iron metaboism. In: Blood, Textbook of Hematology. Little Brown Co., Boston, 1996: 289-362.
18. Sato K, Shiraki M. Saccharated ferric oxide-induced osteomalacia in Japan: iron-induced osteopathy due to nephropathy. Endocrine J 45: 431-439, 1998.
19. Comlekci A, Biberoglu S, Hekimsoy Z, et al. Symptomatic hypocalcemia in a patient with latent hypoparathyroidism and breast carcinoma with bone metastasis following administration of pamidronate. Intern Med 37: 396-397, 1998.
20. Schussheim DH, Jacobs TP, Silverberg SJ. Hypocalcemia associated with alendronate. Ann Intent Med 130: 329, 1999.
21. Kashyap AS, Kashyap S. Hypoparathyroidism unmasked by alendronate. Postgrad Med J 76: 417-418, 2000.
22. Mishra A, Wong L, Jonklaas J. Prolonged, symptomatic hypocalcemia with pamidronate administration and subclinical hypoparathyroidism. Endocrine 14: 159-164, 2001.
23. Nishino K, Hirsch PF, Mahgoub A, Munson PL. Hypocalcemic effect of physiological concentrations of corticosterone in adrenalectomized-parathyroidectomized rats. Endocrinology 128: 2259-2265, 1991.
24. Mahgoub A, Hirsch PF, Munson PL. Calcium-lowering action of glucocorticoids in adrenalectomized-parathyroidectomized rats. Specificity and relative potency of natural and synthetic glucocorticoids. Endocrine 6: 279-283, 1997.
25. Carlstedt F, Lind L, Rastad J, et al. Parathyroid hormone and ionized calcium levels are related to the severity of illness and survival in critically ill patients. Eur J Clin Invest 28: 898-903, 1998.
26. Zaloga GP, Chernow B. The multifactorial basis for hypocalcemia during sepsis. Studies of the parathyroid hormone-vitamin D axis. Ann Intern Med 107: 36-41, 1987.
27. Lind L, Carlstedt F, Rastad J, et al. Hypocalcemia and parathyroid hormone secretion in-critically ill patients. Crit Care Med 28: 93-99, 2000.
28. Canaff L, Hendy GN. Calcium-sensing receptor gene transcription is upregulated by the proinflammatory cytokine, interleukin-1b. J Biol Chem 280: 14177-14188, 2005.
29. Canaff L, Schorr K, Hendy GN. Upregulation of calcium-sensing receptor gene expression by the proinflammatory cytokine, interleukin-6: in vivo and in vitro studies. J Bone Miner Res 22: S53 (abstract 1187), 2007.