Biliary-Type Cytokeratin Pattern in a Canine Isolated Perfused Liver Transplantation Model

Journal of Surgical Research

Volumn 146, Issue 2, 2008, Pages 164-171

  Sergi, Consolato ^a,b   Gross, Wolfgang ^c   Mory, Martin ^c   Schaefer, Michael ^c   Gebhard, Martha Maria ^c  

^a MEDICAL UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

cholestasis; hepatocellular transport; liver transplantation; primary graft dysfunction

Indexed keywords

CYTOKERATIN; INDOCYANINE GREEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CELL FUNCTION; CELL STRUCTURE; COLD ISCHEMIA; CONTROLLED STUDY; ELECTRON MICROSCOPY; FLOW RATE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTRAHEPATIC BILE DUCT; LIVER INJURY; LIVER ISCHEMIA; LIVER PERFUSION; LIVER PRESERVATION; LIVER TRANSPLANTATION; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY;

ANIMALS; BILE; CHOLESTASIS; COLORING AGENTS; DISEASE MODELS, ANIMAL; DOGS; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; KERATINS; LIVER; LIVER TRANSPLANTATION; MICROSCOPY, ELECTRON; REPERFUSION INJURY;

EID: 41649108803     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2007.05.024     Document Type: Article

References (15)

1. Clavien P.A., Harvey P.R., and Strasberg S.M. Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies. Transplantation 53 (1992) 957
2. Serracino-Inglott F., Habib N.A., and Mathie R.T. Hepatic ischemia-reperfusion injury. Am J Surg 181 (2001) 160
3. Kukan M., and Haddad P.S. Role of hepatocytes and bile duct cells in preservation-reperfusion injury of liver grafts. Liver Transpl 7 (2001) 381
4. Ott P. Hepatic elimination of indocyanine green with special reference to distribution kinetics and the influence of plasma protein binding. Pharmacol Toxicol 83 Suppl (1998) 1
5. Yasui H., Yoshimura N., Kobayashi Y., et al. Microstructural changes of bile canaliculi in canine liver: The effect of cold ischemia-reperfusion in orthotopic liver transplantation. Transplant Proc 30 (1998) 3754
6. Shinohara H., Tanaka A., Kitai T., et al. Direct measurement of hepatic indocyanine green clearance with near-infrared spectroscopy: Separate evaluation of uptake and removal. Hepatology 23 (1996) 137
7. Oude Elferink R.P., Frijters C.M., Paulusma C., et al. Regulation of canalicular transport activities. J Hepatol 24 Suppl (1996) 94
8. Kullak-Ublick G.A., Beuers U., and Paumgartner G. Hepatobiliary transport. J Hepatol 32 (2000) 3
9. Keppler D., and Konig J. Hepatic secretion of conjugated drugs and endogenous substances. Semin Liver Dis 20 (2000) 265
10. Shinohara H., Tanaka A., Fujimoto T., et al. Disorganization of microtubular network in postischemic liver dysfunction: Its functional and morphological changes. Biochim Biophys Acta 1317 (1996) 27
11. Haussinger D., Schmitt M., Weiergraber O., and Kubitz R. Short-term regulation of canalicular transport. Semin Liver Dis 20 (2000) 307
12. Rauen U., Reuters I., Fuchs A., et al. Oxygen-free radical-mediated injury to cultured rat hepatocytes during cold incubation in preservation solutions. Hepatology 26 (1997) 351
13. Jaeschke H. Preservation injury: Mechanisms, prevention, and consequences. J Hepatol 25 (1996) 774
14. Vajdova K., Graf R., and Clavien P.A. ATP supplies in the cold-preserved liver: A long-neglected factor of organ viability. Hepatology 36 (2002) 1543
15. St Peter S.D., Imber C.J., and Friend P.J. Liver and kidney preservation by perfusion. Lancet 359 (2002) 604