Dopexamine reverses the vasopressin-associated impairment in tissue oxygen supply but decreases systemic blood pressure in ovine endotoxemia

Anesthesia and Analgesia

Volumn 99, Issue 3, 2004, Pages 878-885

  Westphal, Martin ^a,b   Sielenkämper, Andreas Wilhelm ^a   Van Aken, Hugo ^a   Stubbe, Henning Dirk ^a   Daudel, Fritz ^a   Schepers, Ralf ^a   Schulte, Simone ^a   Bone, Hans Georg ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARGIPRESSIN; CEFTRIAXONE; DOPEXAMINE; ENDOTOXIN; KETANEST; PROPOFOL; VASOPRESSIN;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DOSE RESPONSE; ENDOTOXEMIA; HEART INDEX; HEART OUTPUT; HEART RATE; HYPOTENSION; LUNG ARTERY PRESSURE; LUNG VASCULAR RESISTANCE; NONHUMAN; PRIORITY JOURNAL; SHEEP; SYSTEMIC VASCULAR RESISTANCE; VENOUS OXYGEN TENSION;

ANIMALS; ARGININE VASOPRESSIN; BLOOD PRESSURE; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXEMIA; HEART RATE; OXYGEN; SHEEP;

EID: 4143073786     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000131970.54062.1C     Document Type: Article

References (35)

1. Rivers E, Nguyen B, Havstad S. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-77.
2. Landry DW, Oliver JA. The pathogenesis of vasodilatory shock. N Engl J Med 2001;23:588-95.
3. Patel BM, Chittok DR, Russell JA, Walley KR. Beneficial effects of short-term vasopressin infusion during severe septic shock. Anesthesiology 2002;96:576-82.
4. Dunser AW, Mayer AJ, Ulmer H. Arginine vasopressin in advanced vasodilatory shock: a prospective randomized, controlled study. Circulation 2003;107:2313-9.
5. Landry DW, Levin HR, Gallant EM, et al. Vasopressin pressor hypersensitivity in vasodilatory septic shock. Crit Care Med 1997;25:1279-82.
6. Landry DW, Levin HR, Gallant EM, et al. Vasopressin deficiency contributes to the vasodilation of septic shock. Circulation 1997;95:1122-5.
7. Möhring J, Glänzer K, Maciel JA Jr, et al. Greatly enhanced pressor response to antidiuretic hormone in patients with impaired cardiovascular reflexes due to idiopathic orthostatic hypotension. J Cardiovasc Pharmacol 1980;2:367-76.
8. Dhainaut JF, Schlemmer B, Monsallier JF, et al. Oxygen consumption during septic shock: effects of inotropic drugs. Arch Int Physiol Biochim 1984;92:S57-64.
9. Smith GW, O'Connor SE. An introduction to the pharmacologic properties of Dopacard (dopexamine hydrochloride). Am J Cardiol 1988;62:9C-17C.
10. Smith GW, Hall JC, Farmer JB, Simpson WT. The cardiovascular actions of dopexamine hydrochloride, an agonist at dopamine receptors and beta 2-adrenoceptors in the dog. J Pharm Pharmacol 1987;39:636-41.
11. Waurick R, Bone HG, Meyer J, et al. Haemodynamic effects of dopexamine and nitric oxide synthase inhibition in healthy and endotoxaemic sheep. Eur J Pharmacol 1997;333:181-6.
12. Westphal M, Stubbe H, Sielenkämper AW, et al. Effects of titrated arginine vasopressin on hemodynamic variables and oxygen transport in healthy and endotoxemic sheep. Crit Care Med 2003;31:1502-8.
13. Westphal M, Stubbe H, Bone HG, et al. Hemodynamic effects of exogenous adrenomedullin in healthy and endotoxemic sheep. Biochem Biophys Res Commun 2002;296:134-8.
14. Westphal M, Stubbe H, Sielenkämper AW, et al. Terlipressin dose response in healthy and endotoxemic sheep: impact on cardiopulmonary performance and global oxygen transport. Intensive Care Med 2003;29:301-8.
15. Westphal M, Eletr D, Bone HG, et al. Arteriovenous carboxyhemoglobin difference in critical illness: fiction or fact? Biochem Biophys Res Commun 2002;299:479-82.
16. Meyer J, Booke M, Waurick R, et al. Nitric oxide synthase inhibition restores vasopressor effects of norepinephrine in ovine hyperdynamic sepsis. Anesth Analg 1996;83:1009-13.
17. Traber DL. Animal models: the sheep. Crit Care Med 2000;28: 591-2.
18. Evgenov OV, Hevroy O, Bremnes KE, Bjertnaes LJ. Effect of aminoguanidine on lung fluid filtration in awake sheep. Am J Respir Crit Care Med 2002;162:465-70.
19. Landry DW, Oliver JA. The ATP-sensitive K+ channel mediates hypotension in endotoxemia and hypoxic lactic acidosis in dog. J Clin Invest 1992;89:2071-4.
20. Court O, Kumar A, Parillo JE, Kumar A. Clinical review: myocardial depression in sepsis and septic shock. Crit Care 2002;6: 500-8.
21. Snapper JR, Thabes JS, Lefferts PL, Lu W. Role of endothelin in endotoxin-induced sustained pulmonary hypertension in sheep. Am J Respir Crit Care Med 1998;157:81-8.
22. Fischer LG, Van Aken H, Burkle H. Management of pulmonary hypertension: physiological and pharmacological considerations for anesthesiologists. Anesth Analg 2003;96:1603-16.
23. Holmes CL, Patel BM, Russel JA, Walley KR. Physiology of vasopressin relevant to management of septic shock. Chest 2001;120:989-1002.
24. Leather HA, Segers P, Berends N, et al. Effects of vasopressin on right ventricular function in an experimental model of acute pulmonary hypertension. Crit Care Med 2002;30:2548-52.
25. Courtice GP, Kwong TE, Lumbers ER, Potter EK. Excitation of the cardiac vagus by vasopressin in mammals. J Physiol 1984; 354:547-56.
26. Gettinger A. Mixed venous saturation: the puzzle is still incomplete. Chest 1990;98:786-7.
27. Kandel G, Aberman A. Mixed venous oxygen saturation: its role in the assessment of the critically ill patient. Arch Intern Med 1983;143:1400-2.
28. Westphal M, Freise H, Kehrel B, et al. Arginine vasopressin compromises gut mucosal microcirculation in septic rats. Crit Care Med 2004;32:194-200.
29. Gutierrez G, Wulf ME. Lactic acidosis in sepsis: a commentary. Intensive Care Med 1996;22:6-16.
30. Smithies M, Yee TH, Jackson L, et al. Protecting the gut and the liver in the critically ill: effects of dopexamine. Crit Care Med 1994;22:789-95.
31. Sack FU, Reidenbach B, Schledt A, et al. Dopexamine attenuates microvascular perfusion injury of the small bowel in pigs induced by extracorporal circulation. Br J Anaesth 2002;88:841-7.
32. Bastien O, Piriou V, Aoufi E, et al. Effects of dopexamine on blood flow in multiple splanchnic sites measured by laser Doppler velocimetry in rabbits undergoing cardiopulmonary bypass. Br J Anaesth 1999;82:104-9.
33. Jakob SM, Takala J. Gut perfusion in the critically ill. Intensive Care Med 2000;26:813-5.
34. Bucher M, Hobbhahn J, Taeger K, Kurtz A. Cytokine-mediated downregulation of vasopressin V(1A) receptors during acute endotoxemia in rats. Am J Physiol Regul Integr Comp Physiol 2002;282:R979-84.
35. Versprille A. Pulmonary vascular resistance: a meaningless variable. Intensive Care Med 1984;10:51-3.