Secretory PLA 2 inhibitor indoxam suppresses LDL modification and associated inflammatory responses in TNFα-stimulated human endothelial cells

British Journal of Pharmacology

Volumn 153, Issue 7, 2008, Pages 1399-1408

  Sonoki, K ^a   Iwase, M ^a   Sasaki, N ^a   Ohdo, S ^b   Higuchi, S ^b   Takata, Y ^c   Iida, M ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c KYUSHU DENTAL COLLEGE   (Japan)

Author keywords

Atherosclerosis; Human umbilical vein endothelial cells; Indoxam; Lysophosphatidylcholine; Monocyte chemoattractant protein 1; Nuclear factor B; Secretory phospholipase A 2; Secretory phospholipase A 2 inhibitor

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOXAM; LOW DENSITY LIPOPROTEIN; LYSOPHOSPHATIDYLCHOLINE; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; SNAKE VENOM; THIOETHERAMIDE PHOSPHATIDYLCHOLINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CARBAMIC ACID DERIVATIVE; ENZYME INHIBITOR; INDOLIZINE DERIVATIVE; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; ELECTROSPRAY MASS SPECTROMETRY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; METABOLISM; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

CARBAMATES; CELLS, CULTURED; CHEMOKINE CCL2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; INDOLIZINES; LIPOPROTEINS, LDL; LYSOPHOSPHATIDYLCHOLINES; NF-KAPPA B; PHOSPHOLIPASES A2; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL VEINS;

EID: 41649105483     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.12     Document Type: Article

References (47)

1. 2 expression in rat gastric epithelial cells. J Biol Chem 276: 21854-21862.
2. 2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization. J Biol Chem 270: 8963-8970.
3. 2. Biochim Biophys Acta 1488: 149-158.
4. 2 induce the expression of chemokines in microvascular endothelium. Biochem Biophys Res Commun 300: 731-737.
5. 2 and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study. Arterioscler Thromb Vasc Biol 25: 839-846.
6. 2 promotes atherosclerosis: evidence from genetically altered mice. Arterioscler Thromb Vasc Biol 27: 600-606.
7. 2-modified low density lipoprotein promoted foam cell formation by a SR-A- and CD36-independent process that involves cellular proteoglycans. J Biol Chem 280: 32746-32752.
8. 2, in the treatment of rheumatoid arthritis. J Rheumatol 32: 417-423.
9. Camejo G, Hurt-Camejo E, Wiklund O, Bondjers G (1998). Association of apo B lipoproteins with arterial proteoglycans: pathological significance and molecular basis. Atherosclerosis 139: 205-222.
10. 2s in human neutrophils. J Biol Chem 277: 5061-5073.
11. 2 in the metabolism of lipoproteins. Substrate specifications of the enzymes and the regulation of their activities by sphingomyelin. Biochemistry 41: 4911-4920.
12. 2 in human lung macrophages expressing the M-type receptor. J Immunol 174: 464-474.
13. 2: synthesis and inhibitory activities of indolizine and indene derivatives. J Med Chem 39: 3636-3658.
14. Han X, Gubitosi-Klug RA, Collons BJ, Gross RW (1996). Alterations in individual molecular species of human platelet phospholipids during thrombin stimulation: electrospray ionization mass spectrometry-facilitated identification of the boundary conditions for the magnitude and selectivity of thrombin-induced platelet phospholipid hydrolysis. Biochemistry 35: 5822-5832.
15. 2 is linked to macrophage foam cell formation. J Biol Chem 277: 29116-29124.
16. 2 in normal and atherosclerotic arteries. Activity of the isolated enzyme on low-density lipoproteins. Arterioscler Thromb Vasc Biol 17: 300-309.
17. 2 in vascular disease. Circ Res 89: 298-304.
18. 2. Arterioscler Thromb Vasc Biol 19: 1284-1290.
19. Jaffe EA, Nachman RL, Becker CG, Minick CR (1973). Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52: 2745-2756.
20. 2 gene in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 25: 1161-1167.
21. Kaluzny MA, Duncan LA, Merritt MV, Epps DE (1985). Rapid separation of lipid classes in high yield and purity using bonded phase columns. J Lipid Res 26: 135-140.
22. 2. J Biol Chem 264: 5768-5775.
23. 2 enzymes. Prostaglandins Other Lipid Mediat 68-69: 3-58.
24. 2-alpha. J Biol Chem 279: 25024-25038.
25. 2 isozymes with a potential role in atherosclerosis. Curr Opin Lipidol 14: 431-436.
26. 2. Biol Pharm Bull 27: 1158-1164.
27. 2 associated with cell surfaces via C-terminal heparin-binding lysine residues augments stimulus-initiated delayed prostaglandin generation. J Biol Chem 271: 30041-30051.
28. 2 and lipoprotein lipase enhance 15-lipoxygenase- induced enzymic and nonenzymic lipid peroxidation in low-density lipoproteins. Biochemistry 37: 9203-9210.
29. 2. Biochim Biophys Acta 1736: 38-50.
30. 2 group V: lesion distribution, activation by arterial proteoglycans, and induction in aorta by a Western diet. Arterioscler Thromb Vasc Biol 26: 1421-1422.
31. 2 induces potent productions of various lipid mediators in mouse peritoneal macrophages. Biochim Biophys Acta 1530: 67-76.
32. 2. J Biol Chem 277: 48535-48549.
33. 2 enzymes: classification and characterization. Biochim Biophys Acta 1488: 1-19.
34. Sonoki K, Yoshinari M, Iwase M, Iino K, Ichikawa K, Ohdo S et al. (2002). Glycoxidized low-density lipoprotein enhances MCP-1 mRNA expression in HUVEC. Relation to lysophosphatidylcholine contents and inhibition by nitric oxide donor. Metabolism 51: 1135-1142.
35. 2 and in diabetic patients: Protection by nitric oxide donor. Metabolism 52: 308-314.
36. 2 in rat mesangial cells. Biochim Biophys Acta 1484: 215-224.
37. 2. Eur J Biochem 112: 25-32.
38. Vieira OV, Laranjinha JA, Madeira VM, Almeida LM (1996). Rapid isolation of low density lipoproteins in a concentrated fraction free from water-soluble plasma antioxidants. J Lipid Res 37: 2715-2721.
39. 2. Brain Res 917: 230-234.
40. 2 induces neuronal cell death via apoptosis. Mol Pharmacol 61: 114-126.
41. 2-independent mechanisms. Biochim Biophys Acta 1438: 213-222.
42. 2 receptor. FEBS Lett 478: 187-191.
43. 2 with phospholipid analogues and inhibitors. J Biol Chem 265: 2657-2664.
44. 2 increases atherosclerotic lesion formation in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 23: 263-268.
45. 2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation. Arterioscler Thromb Vasc Biol 24: 762-767.
46. 2 in atherosclerosis: biology, epidemiology, and possible therapeutic target. Arterioscler Thromb Vasc Biol 25: 923-931.
47. 2, fails to improve clinical outcome for patients with severe sepsis. Crit Care Med 33: 1741-1748.