Potent inhibitors of secretory phospholipase A2: Synthesis and inhibitory activities of indolizine and indene derivatives

Journal of Medicinal Chemistry

Volumn 39, Issue 19, 1996, Pages 3636-3658

  Hagishita, Sanji ^a   Yamada, Masaaki ^a   Shirahase, Kazuhiro ^a   Okada, Toshihiko ^a   Murakami, Yasushi ^a   Ito, Yuji ^a   Matsuura, Takaharu ^a   Wada, Masaaki ^a   Kato, Toshiyuki ^a   Ueno, Masahiko ^a   Chikazawa, Yukiko ^a   Yamada, Katsutoshi ^a   Ono, Takashi ^a   Teshirogi, Isao ^a   Ohtani, Mitsuaki ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOGENIC SUBSTRATE; GLYCEROPHOSPHOLIPID; INDENE DERIVATIVE; INDOLIZINE DERIVATIVE; PHOSPHOLIPASE A2; THROMBOCYTE ACTIVATING FACTOR;

ARACHIDONIC ACID METABOLISM; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; OXIDATION; PANCREATITIS; SEPTIC SHOCK; STEREOCHEMISTRY; STOICHIOMETRY;

ALKYLATION; ENZYME INHIBITORS; HUMANS; HYDROXYLATION; INDENES; INDOLIZINES; METHYLATION; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PHOSPHOLIPASES A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 9544235161     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960395q     Document Type: Article

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