Postmortem genetic testing for conventional autopsy-negative sudden unexplained death : An evaluation of different DNA extraction protocols and the feasibility of mutational analysis from archival paraffin-embedded heart tissue

American Journal of Clinical Pathology

Volumn 129, Issue 3, 2008, Pages 391-397

  Carturan, Elisa ^a   Tester, David J ^b   Brost, Brian C ^b   Basso, Cristina ^a   Thiene, Gaetano ^a   Ackerman, Michael J ^b,c  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^b MAYO CLINIC   (United States)

^c College of Medicine ^*

Author keywords

Autopsy; Catecholaminergic polymorphic ventricular tachycardia; DNA extraction; Genetic testing; Paraffin embedded tissue; RYR2; Sudden unexplained death

Indexed keywords

EDETIC ACID; PARAFFIN; RYANODINE RECEPTOR 2; DNA; FORMALDEHYDE; RYANODINE RECEPTOR;

ARTICLE; AUTOPSY; CLINICAL ARTICLE; DNA EXTRACTION; GENETIC ANALYSIS; HEART; HUMAN; HUMAN TISSUE; LABORATORY TEST; MISSENSE MUTATION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; SUDDEN DEATH; DIAGNOSIS; EVALUATION; GENETIC PROCEDURES; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; POLYMERASE CHAIN REACTION; TISSUE FIXATION;

AUTOPSY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEATH, SUDDEN; DEATH, SUDDEN, CARDIAC; DIAGNOSIS; DNA; DNA MUTATIONAL ANALYSIS; EVALUATION STUDIES AS TOPIC; FORMALDEHYDE; GENETIC TECHNIQUES; HEART; HUMANS; PARAFFIN EMBEDDING; POLYMERASE CHAIN REACTION; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; TISSUE FIXATION;

EID: 41649090413     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/VLA7TT9EQ05FFVN4     Document Type: Article

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