Carboxypeptidase e cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones

Molecular Endocrinology

Volumn 22, Issue 4, 2008, Pages 989-1005

  Park, Joshua J ^a   Cawley, Niamh X ^a   Loh, Y Peng ^a,b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYPEPTIDASE H; CELL PROTEIN; DYNACTIN; KINESIN 2; KINESIN 3; PEPTIDE HORMONE; PROOPIOMELANOCORTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOCHEMISTRY; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; HORMONE RELEASE; HYPOPHYSIS CELL; INTRACELLULAR TRANSPORT; MICROTUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SECRETION; VELOCITY;

ADRENOCORTICOTROPIC HORMONE; AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT; CARBOXYPEPTIDASE H; CELLS, CULTURED; CYTOPLASMIC VESICLES; IMMUNOPRECIPITATION; KINESIN; MICE; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; MOLECULAR SEQUENCE DATA; PEPTIDE HORMONES; PRO-OPIOMELANOCORTIN; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 41649089832     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2007-0473     Document Type: Article

References (43)

1. Alexander K, Nikodemova M, Kucerova J, Strbak V 2005 Colchicine treatment differently affects releasable thyrotropin-releasing hormone (TRH) pools in the hypothalamic paraventricular nucleus (PVN) and the median eminence (ME). Cell Mol Neurobiol 25:681-695
2. Rudolf R, Salm T, Rustom A, Gerdes HH 2001 Dynamics of immature secretory granules: role of cytoskeletal elements during transport, cortical restriction, and F-actindependent tethering. Mol Biol Cell 12:1353-1365
3. Hamm-Alvarez SF, Da Costa S, Yang T, Wei X, Gierow JP, Mircheff AK 1997 Cholinergic stimulation of lacrimal acinar cells promotes redistribution of membrane-associated kinesin and the secretory protein, β-hexosaminidase, and increases kinesin motor activity. Exp Eye Res 64:141-156
4. Senda T, Yu W 1999 Kinesin cross-bridges between neurosecretory granules and microtubules in the mouse neurohypophysis. Neurosci Lett 262:69-71
5. Pack-Chung E, Kurshan PT, Dickman DK, Schwarz TL 2007 A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport. Nat Neurosci 10:980-989
6. Goldstein LS, Yang Z 2000 Microtubule-based transport systems in neurons: the roles of kinesins and dyneins. Annu Rev Neurosci 23:39-71
7. Schroer TA 2004 Dynactin. Annu Rev Cell Dev Biol 20:759-779
8. Jordens I, Marsman M, Kuijl C, Neefjes J 2005 Rab proteins, connecting transport and vesicle fusion. Traffic 6:1070-1077
9. Inomata H, Nakamura Y, Hayakawa A, Takata H, Suzuki T, Miyazawa K, Kitamura N 2003 A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. J Biol Chem 278:22946-22955
10. Taru H, Iijima K, Hase M, Kirino Y, Yagi Y, Suzuki T 2002 Interaction of Alzheimer's β-amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. J Biol Chem 277:20070-20078
11. Zhu X, Wu K, Rife L, Cawley NX, Brown B, Adams T, Teofilo K, Lillo C, Williams DS, Loh YP, Craft CM 2005 Carboxypeptidase E is required for normal synaptic transmission from photoreceptors to the inner retina. J Neurochem 95:1351-1362
12. Fricker LD, Das B, Angeletti RH 1990 Identification of the pH-dependent membrane anchor of carboxypeptidase E (EC 3.4.17.10). J Biol Chem 265:2476-2482
13. Lou H, Kim SK, Zaitsev E, Snell CR, Lu B, Loh YP 2005 Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase E. Neuron 45:245-255
14. Fricker LD, Snyder SH 1982 Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules. Proc Natl Acad Sci USA 79:3886-3890
15. Hook VY, Loh YP 1984 Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary. Proc Natl Acad Sci USA 81:2776-2780
16. Cool DR, Normant E, Shen F, Chen HC, Pannell L, Zhang Y, Loh YP 1997 Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. Cell 88:73-83
17. Dhanvantari S, Arnaoutova I, Snell CR, Steinbach PJ, Hammond K, Caputo GA, London E, Loh YP 2002 Carboxypeptidase E, a prohormone sorting receptor, is anchored to secretory granules via a C-terminal transmembrane insertion. Biochemistry 41:52-60
18. Dhanvantari S, Loh YP 2000 Lipid raft association of carboxypeptidase E is necessary for its function as a regulated secretory pathway sorting receptor. J Biol Chem 275:29887-29893
19. Arnaoutova I, Jackson CL, Al-Awar OS, Donaldson JG, Loh YP 2003 Recycling of Raft-associated prohormone sorting receptor carboxypeptidase E requires interaction with ARF6. Mol Biol Cell 14:4448-4457
20. Wu CM, Chang HT, Chang MD 2004 Membrane-bound carboxypeptidase E facilitates the entry of eosinophil cationic protein into neuroendocrine cells. Biochem J 382:841-848
21. Guillemin R, Vargo T, Rossier J, Minick S, Ling N, Rivier C, Vale W, Bloom F 1977 β-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland. Science 197:1367-1369
22. Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG 2000 Central nervous system control of food intake. Nature 404:661-671
23. Mandelkow E, Johnson KA 1998 The structural and mechanochemical cycle of kinesin. Trends Biochem Sci 23:429-433
24. Sakato M, King SM 2004 Design and regulation of the AAA+ microtubule motor dynein. J Struct Biol 146:58-71
25. Park JH 2003 Roles for the dynactin complex in the glucocorticoid receptor signaling pathway. PhD thesis, Johns Hopkins University, Baltimore, MD
26. Bingham JB, King SJ, Schroer TA 1998 Purification of dynactin and dynein from brain tissue. Methods Enzymol 298:171-184
27. Okada Y, Hirokawa N 2000 Mechanism of the single-headed processivity: diffusional anchoring between the K-loop of kinesin and the C terminus of tubulin. Proc Natl Acad Sci USA 97:640-645
28. Quintyne NJ, Gill SR, Eckley DM, Crego CL, Compton DA, Schroer TA 1999 Dynactin is required for microtubule anchoring at centrosomes. J Cell Biol 147:321-334
29. Fernandez CJ, Haugwitz M, Eaton B, Moore HP 1997 Distinct molecular events during secretory granule biogenesis revealed by sensitivities to brefeldin A. Mol Biol Cell 8:2171-2185
30. Deacon SW, Serpinskaya AS, Vaughan PS, Lopez Fanarraga M, Vernos I, Vaughan KT, Gelfand VI 2003 Dynactin is required for bidirectional organelle transport. J Cell Biol 160:297-301
31. Dell KR 2003 Dynactin polices two-way organelle traffic. J Cell Biol 160:291-293
32. King SJ, Schroer TA 2000 Dynactin increases the processivity of the cytoplasmic dynein motor. Nat Cell Biol 2:20-24
33. Berezuk MA, Schroer TA 2007 Dynactin enhances the processivity of kinesin-2. Traffic 8:124-129
34. Okada Y, Yamazaki H, Sekine-Aizawa Y, Hirokawa N 1995 The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors. Cell 81:769-780
35. Burkhardt JK, Echeverri CJ, Nilsson T, Vallee RB 1997 Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution. J Cell Biol 139:469-484
36. Klopfenstein DR, Vale RD 2004 The lipid binding pleckstrin homology domain in UNC-104 kinesin is necessary for synaptic vesicle transport in Caenorhabditis elegans. Mol Biol Cell 15:3729-3739
37. Jacob TC, Kaplan JM 2003 The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions. J Neurosci 23:2122-2130
38. Kondo S, Sato-Yoshitake R, Noda Y, Aizawa H, Nakata T, Matsuura Y, Hirokawa N 1994 KIF3A is a new microtubule-based anterograde motor in the nerve axon. J Cell Biol 125:1095-1107
39. Yamazaki H, Nakata T, Okada Y, Hirokawa N 1995 KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport. J Cell Biol 130:1387-1399
40. Yamazaki H, Nakata T, Okada Y, Hirokawa N 1996 Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B. Proc Natl Acad Sci USA 93:8443-8448
41. Shakiryanova D, Tully A, Levitan ES 2006 Activity-dependent synaptic capture of transiting peptidergic vesicles. Nat Neurosci 9:896-900
42. Cheung S, Hammer Jr RP 1995 Gonadal steroid hormone regulation of proopiomelanocortin gene expression in arcuate neurons that innervate the medial preoptic area of the rat. Neuroendocrinology 62:283-292
43. Loh YP, Parish DC, Tuteja R 1985 Purification and characterization of a paired basic residue-specific pro-opiomelanocortin converting enzyme from bovine pituitary intermediate lobe secretory vesicles. J Biol Chem 260:7194-7205