The antiproton depth-dose curve measured with alanine detectors

Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

Volumn 266, Issue 6, 2008, Pages 929-936

  Bassler, Niels ^a,b   Hansen, Johnny W ^c   Palmans, Hugo ^d   Holzscheiter, Michael H ^e   Kovacevic, Sandra ^f  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c LILLEBAELT HOSPITAL   (Denmark)

^d NATIONAL PHYSICAL LABORATORY   (United Kingdom)

^e UNIVERSITY OF NEW MEXICO   (United States)

^f UNIVERSITY OF MONTENEGRO   (Montenegro)

Author keywords

Alanine; Antiproton annihilation; Mixed radiation field dosimetry

Indexed keywords

ALANINE; ANTIPROTON ANNIHILATION; MIXED RADIATION FIELD DOSIMETRY;

BIOCONVERSION; BRAGG CELLS; CHARGED PARTICLES; DOSIMETRY; MATHEMATICAL MODELS; RADIATION DETECTORS;

AMINO ACIDS;

EID: 41549142599     PISSN: 0168583X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nimb.2008.01.067     Document Type: Article

References (47)

1. Gray L., and Kalogeropoulos T.E. Possible biomedical applications of antiproton beams: focused radiation transfer. Radiat. Res. (1984) 246
2. Sullivan A.H. A measurement of the local energy deposition by antiprotons coming to rest in tissue-like material. Phys. Med. Biol. 30 12 (1985) 1297
3. Loeffler J.S., Smith A.R., and Suit H.D. The potential role of proton beams in radiation oncology. Semin. Oncol. 24 6 (1997) 686
4. Wouters B.G., Lam G.K.Y., Oelfke U., Gardey K., Durand R.E., and Skarsgard L.D. Measurements of relative biological effectiveness of the 70 MeV proton beam at TRIUMF using chinese hamster V79 cells and the high-precision cell sorter assay. Radiat. Res. 146 2 (1996) 159
5. 16O ions. Nucl. Instr. and Meth. B 5 (1984) 497
6. Holzscheiter M.H., Agazarayan N., Bassler N., Beyer G., DeMarco J.J., Doser M., Ichioka T., Iwamoto K.S., Knudsen H.V., Landua R., Maggiore C., McBride W.H., Møller S.P., Petersen J., Smathers J.B., Skarsgard L.D., Solberg T.D., Uggerhøj U.I., Rodney Withers H., Vranjes S., Wong M., and Wouters B.G. Biological effectiveness of antiproton annihilation. Nucl. Instr. and Meth. B 221 (2004) 210
7. Maggiore C., Agazarayan N., Bassler N., Blackmore E., Beyer G., DeMarco J.J., Doser M., Gruhn C.R., Holzscheiter M.H., Ichioka T., Iwamoto K.S., Knudsen H.V., Landua R., McBride W.H., Møller S.P., Petersen J., Smathers J.B., Skarsgard L.D., Solberg T.D., Uggerhøj U.I., Rodney Withers H., and Wouters B.G. Biological effectiveness of antiproton annihilation. Nucl. Instr. and Meth. B 214 (2004) 181
8. Holzscheiter M.H., Bassler N., Agazaryan N., Beyer G., Blackmore E., DeMarco J.J., Doser M., Durand R.E., Hartley O., Iwamoto K.S., Knudsen H.V., Landua R., Maggiore C., McBride W.H., Møller S.P., Petersen J., Skarsgard L.D., Smathers J.B., Solberg T.D., Uggerhøj U.I., Vranjes S., Rodney Withers H., Wong M., and Wouters B.G. The biological effectiveness of antiproton irradiation. Radiother. Oncol. 81 3 (2006) 233
9. Grusell E., and Medin J. General characteristics of the use of silicon diode detectors for clinical dosimetry in proton beams. Phys. Med. Biol. 45 9 (2000) 2573
10. Onori S., De Angelis C., Fattibene P., Pacilio M., Petetti E., Azario L., Miceli R., Piermattei A., Barone Tonghi L., Cuttone G., and Lo Nigro S. Dosimetric characterization of silicon and diamond detectors in low-energy proton beams. Phys. Med. Biol. 45 (2000) 3045
11. Sakama M., Kanai T., Kase Y., Komori M., Fukumura A., and Kohno T. Responses of a diamond detector to high-LET charged particles. Phys. Med. Biol. 50 (2005) 2275
12. Piermattei A., Miceli R., Azario L., Fidanzio A., delle Canne S., De Angelis C., Onori S., Pacilio M., Petetti E., Raffaele L., and Sabini M.G. Radiochromic film dosimetry of a low energy proton beam. Med. Phys. 27 7 (2000) 1655
13. Palmans H. Effect of alanine energy response and phantom material on depth-dose measurements in ocular protons beams. Technol. Cancer Res. Treat. 2 6 (2003) 579
14. Attix F.H. Introduction to Radiological Physics and Radiation Dosimetry (1986), John Wiley & Sons
15. Kanai T., Sudo M., Matsufuji N., and Futami Y. Initial recombination in a parallel-plate ionization chamber exposed to heavy ions. Phys. Med. Biol. 43 (1998) 3549
16. Palmans H., Thomas R., and Kacperek A. Ion recombination correction in the clatterbridge centre of oncology clinical proton beam. Phys. Med. Biol. 51 (2006) 903
17. Park S.H., Kim Y.K., Kim H.S., Kang S.M., and Ha J.H. Characteristics of the saturation curve of the ionization chambers in overlapping pulsed beams. Nucl. Instr. and Meth. A 566 (2006) 706
18. Boag J.W., and Currant J. Current collection and ionic recombination in small cylindrical ionization chambers exposed to pulsed radiation. Brit. J. Radiol. 53 (1980) 471
19. Boag J.W., Hochhäuser E., and Balk O.A. The effect of free-electron collection on the recombination correction to ionization measurements of pulsed radiation. Phys. Med. Biol. 41 (1996) 885
20. Bassler N., Holzscheiter M.H., Jäkel O., Knudsen H.V., Kovacevic S., and and the AD-4/ACE Collaboration. The antiproton depth-dose curve in water. Phys. Med. Biol. 53 (2008) 793-805
21. N. Bassler, Experimental studies relevant for antiproton cancer therapy, PhD Thesis, Aarhus University, May 2006.
22. Bradshaw W.W., Cadena D., Crawford G.W., and Soetzler H.A.W. The use of alanine as a solid dosimeter. Radiat. Res. 17 (1962) 11
23. Hansen J.W., Olsen K.J., and Wille M. The alanine radiation detector for high and low LET dosimetry. Radiat. Prot. Dosim. 19 1 (1987) 43
24. Kuhdoh H., Celina M., Kaye R.J., Gillen K.T., and Clough R.L. Response of alanine dosimeters at very high dose rate. Appl. Radiat. Isotopes 48 4 (1997) 497
25. Hansen J.W., and Olsen K.J. Theoretical and experimental radiation effectiveness of the free radical dosimeter alanine to irradiation with heavy charged particles. Radiat. Res. 104 (1985) 15
26. Olsen K.J., and Hansen J.W. The response of the alanine dosemeter to low energy protons and high energy heavy charged particles. Radiat. Prot. Dosim. 31 1/4 (1990) 81
27. Butts J.J., and Katz R. Theory of RBE for heavy ion bombardment of dry enzymes and viruses. Radiat. Res. 30 (1967) 855
28. Katz R., Sharma S.C., and Homayoonfar M. The structure of particle tracks. In: Attix F.H. (Ed). Topics of Radiation Dosimetry (1972), Academic Press, New York 317 (Suppl. 1)
29. J.W. Hansen, Experimental investigation of the suitability of the track structure theory in describing the relative effectiveness of high-LET irradiation of physical radiation detectors, PhD Thesis, Risø National Laboratory, DK-4000 Roskilde, Risø-R-507, 1984.
30. Hansen J.W., and Olsen K.J. Predicting decay in free-radical concentration in l-α-alanine following high-LET radiation exposures. Appl. Radiat. Isotopes 40 10-12 (1989) 935
31. Sharpe P.H., Rajendran K., and Sephton J.P. Progress towards an alanine/ESR therapy level reference dosimetry service at NPL. Appl. Radiat. Isotopes 47 11-12 (1996) 1171
32. Sharpe P., and Sephton J. An automated system for the measurement of alanine/EPR dosimeters. Appl. Radiat. Isotopes 52 5 (2000) 1185
33. A. Fassò, A. Ferrari, J. Ranft, P.R. Sala, FLUKA: a multi-particle transport code. CERN-2005-10, INFN/TC_05/11, SLAC-R-773.
34. A. Fassò, A. Ferrari, S. Roesler, P.R. Sala, G. Battistoni, F. Cerutti, E. Gadioli, M.V. Garzelli, F. Ballarini, A. Ottolenghi, A. Empl, J. Ranft, The physics models of FLUKA: status and recent developments. In Computing in High Energy and Nuclear Physics 2003 Conference (CHEP2003), La Jolla, CA, USA, March 24-28 2003. (paper MOMT005), eConf C0303241 (2003), arXiv:hepph/0306267.
35. Møller S.P., Csete A., Ichioka T., Knudsen H., Uggerhøj U.I., and Andersen H.H. Antiprotons stopping at low energies: confirmation of velocity-proportional stopping power. Phys. Rev. Lett. 88 19 (2002) 193201-1
36. M.J. Berger, J.S. Coursey, M.A. Zucker, J. Chang, Stopping-power and range tables for electrons, protons, and helium ions, .
37. H. Paul, A. Schinner, MSTAR, .
38. 18Ar. Nucl. Instr. and Meth. B 179 (2001) 299
39. Polster D., Hilscher D., Rossner H., von Egidy T., Hartmann F.J., Hoffmann J., Schmid W., Pshenichnov I.A., Iljinov A.S., Golubeva Ye.S., Machner H., Plendl H.S., Grouchulska A., Jastrzebski J., Kurcewiz W., Lubinski P., Eades J., and Neumaier S. Light particle emission induced by stopped antiprotons in nuclei: energy dissipation and neutron-to-proton ratio. Phys. Rev. C 51 3 (1995) 1167
40. Besserer J., Bilski P., de Boer J., Kwiecien T., Moosburger M., Olko P., and Quicken P. Dosimetry of low-energy protons and light ions. Phys. Med. Biol. 46 (2001) 473
41. Kalef-Ezra J., and Horowitz Y.S. Heavy charged particle thermoluminescence dosimetry: track structure theory and experiments. Int. J. Appl. Radiat. Isotopes 33 (1982) 1085
42. Gerstenberg H.M., Hansen J.W., Coyne J.J., and Zoetelief J. Calculations of the relative effectiveness of alanine for neutrons with energies up to 17.1 MeV. Radiat. Prot. Dosim. 31 1/4 (1990) 85
43. M. Scholz, Grundlagen der biologischen Bestrahlungsplanung fur die Schwerionen-Tumortherapie, Medizinische Fakultat Heidelberg, Ruprecht-Karls-Universität, Habilitationsschrift (in German).
44. Scholz M., and Kraft G. Track structure and the calculation of biological effects of heavy charged particles. Adv. Space Res. 18 1/2 (1995) 5
45. Scholz M., Kellerer A.M., and Kraft-Weyrather W. Computation of cell survival in heavy ion beams for therapy. Radiat. Environ. Biophys. 36 (1997) 59
46. Geiß O.B., Krämer M., and Kraft G. Efficiency of thermoluminescent detectors to heavy charged particles. Nucl. Instr. and Meth. B 142 (1998) 592
47. Paganetti H., and Goitein M. Biophysical modelling of proton radiation effects based on amorphous track models. Int. J. Radiat. Biol. 77 9 (2001) 911