The importance of the PrP genotype in active surveillance for ovine scrapie

Epidemiology and Infection

Volumn 136, Issue 5, 2008, Pages 703-712

  Tongue, S C ^a   Wilesmith, J W ^b   Nash, J ^a   Kossaibati, M ^a   Ryan, J ^a  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

^b Food and Farming Group   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ANIMAL DISEASE; ARTICLE; DISEASE CONTROL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE FREQUENCY; GENOTYPE; NONHUMAN; RISK FACTOR; SCRAPIE; SCREENING TEST; SHEEP DISEASE; UNITED KINGDOM; WESTERN BLOTTING;

ANIMALS; ENVIRONMENTAL MONITORING; FALSE NEGATIVE REACTIONS; GENOTYPE; GREAT BRITAIN; PREVALENCE; PRIONS; SCRAPIE; SENSITIVITY AND SPECIFICITY; SHEEP;

EID: 41549141846     PISSN: 09502688     EISSN: 14694409     Source Type: Journal    
DOI: 10.1017/S0950268807008928     Document Type: Article

References (22)

1. Hoinville LJ, et al. Descriptive epidemiology of scrapie in Great Britain: Results of a postal survey. Veterinary Record 2000; 146: 455-461.
2. Sivam SK, et al. Descriptive analysis of the results of an anonymous postal survey of the occurrence of scrapie in Great Britain in 2002. Veterinary Record 2006; 158: 501-506.
3. Simmons MM, et al. Scrapie surveillance in Great Britain: results of an abattoir survey, 1997/98. Veterinary Record 2000; 146: 391-395.
4. EC (2001). Regulation.No. 999/2001 of the European Parliament and of the Council of 22 May 2001 laying down rules for the prevention, control and eradication of certain Transmissible Spongiform Encephalopathies. OJ L147 of 31.05.2001, pp. 1-40 and subsequent amendments.
5. EFSA. EFSA Scientific Report (2005), 31 1-17 on the evaluation of rapid post mortem TSE tests intended for small ruminants.
6. Baylis M, et al. Risk of scrapie in British sheep of different prion protein genotype. Journal of General Virology 2004; 85: 2735-2740.
7. Tongue SC, et al. Estimation of the relative risk for developing clinical scrapie: The role of prion protein (PrP) genotype and selection bias. Veterinary Record 2006; 158: 43-50.
8. Wilesmith JW, Matthews D, Ryan J. Summary of the results of scrapie surveillance in sheep in Great Britain, January 2002-March 2003. 2003 (http://www.defra.gov.uk/animalh/bse/publications/reports/ SheepSurveyrpt.pdf). Accesed November 2004.
9. Elliott H, et al. Prevaleace of scrapie in sheep in Great Britain estimated from abattoir surveys during 2002 and 2003. Veterinary Record 2005; 157: 418-419.
10. Del Rio Villas V, et al. Prevalence of scrapie in sheep: results from fallen stock surveys in Great Britain in 2002 and 2003. Veterinary Record 2005; 157: 744-745.
11. Everest SJ, et al. Atypical prion protein in sheep brain collected during the British scrapie surveillance programme. Journal of General Virology 2006; 87: 471-477.
12. Anon. Opinion of the Scientific Panel on Biological Hazards on the request from the European Commission on classification of atypical Transmissible Encephalopathy (TSE) cases in Small Ruminants. EFSA Journal 2005; 276: 1-30.
13. Wilesmith JW, et al. Summary of the results of scrapie surveillance in sheep in Great Britain, 2004 (http://www.defra.gov.uk/ animalh/bse/publications/reports/SheepSurvey2.pdf). Accessed April 2005.
14. Buschmann A, et al. Atypical scrapie cases in Germany and France are identified by discrepant reaction patterns in BSE rapid tests. Journal of Virological Methods 2004; 117: 27-36.
15. Orge L, et al. Identification of putative atypical scrapie in sheep in Portugal. Journal of General Virology 2004; 85: 3487-3491.
16. Onnasch H, et al. Two Irish cases of scrapie resembling Nor98. (2004) Veterinary Record 2004; 155: 636-637.
17. De Bowhere H, et al. TSE detected in a Belgian ARR-homozygous sheep via active surveillance. Veterinary Journal 2007; 173: 449-451.
18. Le Dur A, et al. A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes. Proceedings of the National Academy of Sciences USA 2005; 102: 160il-16036.
19. Moum T, et al. Polymorphisms at codons 141 and 154 in the ovine prion protein gene are associated with scrapie Nor 98 cases. Journal of General Virology 2005; 86: 231-235.
20. Saunders GC, et al. PrP genotype of atypical scrapie cases in Great Britain. Journal of General Virology 2006; 87: 3141-3149.
21. Bossers A, de Vries R, Smits MA. Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP. Journal of Virology 2000; 74: 1407-1414.
22. Morignat E, et al. Estimates of the prevalence of transmissible spongiform encephalopathies in sheep and goats in France in 2002. Veterinary Record 2006; 158: 683-687.