Synthesis of dimethyl substituted benzimidazoles containing cyclopropane fused onto five to eight membered [1,2-a]alicyclic rings and influence of methyl group substituents on cytotoxicity of benzimidazolequinones

Tetrahedron

Volumn 64, Issue 19, 2008, Pages 4196-4203

  Hehir, Sarah ^a   O'Donovan, Liz ^a   Carty, Michael P ^a   Aldabbagh, Fawaz ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Antitumor agents; Aziridinylimines; Cycloaddition; Heterocycles

Indexed keywords

(1 ALLYL 5,6 DIMETHYL 1H BENZIMIDAZOL 2 YL) METHANOL; (1 BUT 3 ENYL 5,6 DIMETHYL 1H BENZIMIDAZOL 2 YL)METHANOL; (1 HEX 5 ENYL 5,6 DIMETHYL 1H BENZIMIDAZOL 2 YL)METHANOL; (1 PENT 4 ENYL 5,6 DIMETHYL 1H BENZIMIDAZOL 2 YL)METHANOL; 1 ALLYL 5,6 DIMETHYL 1H BENZIMIDAZOLE 2 CARBALDEHYDE; 1 BUT 3 ENYL 5,6 DIMETHYL 1H BENZIMIDAZOLE 2 CARBALDEHYDE; 1 HEX 5 EN 1 YL 5,6 DIMETHYL 1H BENZIMIDAZOLE 2 CARBALDEHYDE; 1 PENT 4 EN 1 YL 5,6 DIMETHYL 1H BENZIMIDAZOLE 2 CARBALDEHYDE; 4,5 DIMETHYL 1,1A,8,8A TETRAHYDROCYCLOPROPA[3,4]PYRROLO[1,2 A]BENZIMIDAZOLE; 4,5 DIMETHYL 1,1A,8,8A TETRAHYDROCYCLOPROPA[3,4]PYRROLO[1,2 A]BENZIMIDAZOLE 3,6 DIONE; 4,5 DIMETHYLCYCLOPROPA[3,4]PYRROLO[1,2 A]BENZIMIDAZOLE 3,6 DIONE; 4,5 DIMETHYLCYCLOPROPAPYRROLO[1,2 A]BENZIMIDAZOLEQUINONE; 6,7 DIMETHYL 1A,2,3,9B TETRAHYDRO 1H CYCLOPROPA[3,4]PYRIDO[1,2 A]BENZIMIDAZOLE; 7,8 DIMETHYL 1,1A,3,4,10B HEXAHYDROCYCLOPROPA[3,4]AZEPINO[1,2 A]BENZIMIDAZOLE; 7,8 DIMETHYL 3,3A,4,10B TETRAHYDROPYRAZOLO[3',4':3,4]PYRROLO[1,2 A]BENZIMIDAZOLE; 8,9 DIMETHYL 1A,2,3,4,5,11B HEXAHYDRO 1H CYCLOPROPA[3,4]AZOCINO[1,2 A]BENZIMIDAZOLE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; BENZIMIDAZOLEQUINONE DERIVATIVE; CARBENE; CYCLOPROPANE; CYCLOPROPAPYRROLOL[1,2 A]BENZIMIDAZOLEQUINONE; HYDRAZONE DERIVATIVE; N [(ALLYL 5,6 DIMETHYL 1H BENZIMIDAZOL 2 YL)METHYLENE] 2,3 DIPHENYLAZIRIDIN 1 AMINE; N [(BUT 3 ENYL 5,6 DIMETHYL 1H BENZIMIDAZOL 2 YL)METHYLENE] 2,3 DIPHENYLAZIRIDIN 1 AMINE; N [(HEX 5 ENYL 5,6 DIMETHYL 1H BENZIMIDAZOL 2 YL)METHYLENE] 2,3 DIPHENYLAZIRIDIN 1 AMINE; N [(PENT 4 ENYL 5,6 DIMETHYL 1H BENZIMIDAZOL 2 YL)MEHYLENE] 2,3 DIPHENYLAZIRIDIN 1 AMINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; CYCLOADDITION; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SKIN FIBROBLAST;

EID: 41549123952     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2008.02.093     Document Type: Article

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