Mouse organic anion transporter 2 (mOat2) mediates the transport of short chain fatty acid propionate

Journal of Pharmacological Sciences

Volumn 106, Issue 3, 2008, Pages 525-528

  Islam, Rafiqul ^a   Anzai, Naohiko ^a   Ahmed, Nesar ^a   Ellapan, Babu ^a   Chun, Ji Jin ^a   Srivastava, Sunena ^a   Miura, Daisaku ^a   Fukutomi, Toshiyuki ^a   Kanai, Yoshikatsu ^a   Endou, Hitoshi ^a  

^a KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Organic anion transporter; Propionate; Short chain fatty acid

Indexed keywords

BUTYRIC ACID; HEPTANOIC ACID DERIVATIVE; HEXANOIC ACID; OCTANOIC ACID; ORGANIC ANION TRANSPORTER 2; PROPIONIC ACID; PROSTAGLANDIN E2 TRITIUM; RADIOPHARMACEUTICAL AGENT; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; VALERIC ACID;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; FATTY ACID TRANSPORT; FEMALE; GLUCOGENESIS; KIDNEY; LIVER; NONHUMAN; XENOPUS LAEVIS;

EID: 41549111500     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.SC0070291     Document Type: Article

References (14)

1. Anzai N, Kanai Y, Endou H. Organic anion transporter family: current knowledge. J Pharmacol Sci. 2006;100:411-426.
2. Monte JC, Nagle MA, Eraly SA, Nigam SK. Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun. 2004;323:429-436.
3. Shin HJ, Anzai N, Enomoto A, He X, Kim do K, Endou H, et al. Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. Hepatology. 2007;45:1046-1055.
4. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, et al. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998;429:179-182.
5. Ljubojevic M, Balen D, Breljak D, Kusan M, Anzai N, Bahn A, et al. Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones. Am J Physiol Renal Physiol. 2007;292:F361-F372.
6. Kobayashi Y, Ohshiro N, Sakai R, Ohbayashi M, Kohyama N, Yamamoto T. Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005;57:573-578.
7. Popowski K, Eloranta JJ, Saborowski M, Fried M, Meier PJ, Kullak-Ublick GA. The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids. Mol Pharmacol. 2005;67:1629-1638.
8. He X, Anzai N, Ueno T, Fukutomi T, Sakata T, Endou H, et al. Trasport of nicotinate by human organic anion transporter hOAT2 and its possible interaction with transport of salicylate [abstract]. J Pharmacol Sci. 2006;100 Suppl I:126P.
9. Bergman EN. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiol Rev. 1990;70:567-590.
10. Kobayashi Y, Ohshiro N, Shibusawa A, Sasaki T, Tokuyama S, Sekine T, et al. Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002;62:7-14.
11. Nilwarangkoon S, Anzai N, Shiraya K, Yu E, Islam R, Cha SH, et al. Role of mouse organic anion transporter 3 (mOat3) as a basolateral prostaglandin E2 transport pathway. J Pharmacol Sci. 2007;103:48-55.
12. Sellin JH. SCFAs: The Enigma of Weak Electrolyte Transport in the Colon. News Physiol Sci. 1999;14:58-64.
13. Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, et al. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem. 2003;278:11312-11319.
14. Xiong Y, Miyamoto N, Shibata K, Valasek MA, Motoike T, Kedzierski RM, et al. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A. 2004;101:1045-1050.