Electrocardiographic interventricular dispersion of repolarization during autonomic adaptation in LQT1 subtype of long QT syndrome

Scandinavian Cardiovascular Journal

Volumn 42, Issue 2, 2008, Pages 130-136

  Haapalahti, Petri ^a   Viitasalo, Matti ^a   Perhonen, Merja ^a   Mäkijärvi, Markku ^a   Väänänen, Heikki ^a,b   Oikarinen, Lasse ^a   Salorinne, Yrjö ^a   Swan, Heikki ^a   Toivonen, Lauri ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b AALTO UNIVERSITY   (Finland)

Author keywords

Autonomic nervous system; Electrocardiography; Long QT syndrome; QT dispersion; QT interval

Indexed keywords

POTASSIUM CHANNEL KCNQ1;

ADAPTATION; ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISPERSION; ELECTROCARDIOGRAM; ELECTROCARDIOGRAPHY; ELECTRODE; EXERCISE; FEMALE; GENE MUTATION; GENETIC DISORDER; HAND GRIP; HEART LEFT VENTRICLE; HEART REPOLARIZATION; HEART RIGHT VENTRICLE; HETEROZYGOTE; HUMAN; LONG QT SYNDROME; MALE; MENTAL STRESS; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; SUPINE POSITION; SYMPATHETIC TONE; VALSALVA MANEUVER;

ADULT; AUTONOMIC NERVOUS SYSTEM; BODY SURFACE POTENTIAL MAPPING; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; EXERCISE; FEMALE; HEART CONDUCTION SYSTEM; HETEROZYGOTE; HUMANS; KCNQ1 POTASSIUM CHANNEL; LONG QT SYNDROME; MALE; MIDDLE AGED; STRESS, PSYCHOLOGICAL; VALSALVA MANEUVER;

EID: 41549092316     PISSN: 14017431     EISSN: 16512006     Source Type: Journal    
DOI: 10.1080/14017430701805419     Document Type: Article

References (20)

1. Wang Q, Curran ME, Splawski I, Burn TC, Milholland JM, VanRaay TJ, et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet. 1996;12:17-23.
2. Yan G, Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation. 1998;98:1928-36.
3. Tanabe Y, Inagaki M, Kurita T, Nagaya N, Taguchi A, Suyama K, et al. Sympathetic stimulation produces a greater increase in both transmural and spatial dispersion of repolarization in LQT1 than LQT2 forms of congenital long QT syndrome. J Am Coll Cardiol. 2001;37:911-9.
4. Volders PG, Sipido KR, Carmeliet E, Spatjens RL, Wellens HJ, Vos MA. Repolarizing K+ currents ITO1 and IKs are larger in right than left canine ventricular midmyocardium. Circulation. 1999;99:206-10.
5. Di Diego JM, Sun ZQ, Antzelevitch C. I(to) and action potential notch are smaller in left vs. right canine ventricular epicardium. Am J Physiol. 1996;271:H548-61.
6. Vos MA, de Groot SH, Verduyn SC, van der Zande J, Leunissen HD, Cleutjens JP, et al. Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling. Circulation. 1998;98:1125-35.
7. Verduyn SC, Vos MA, van der Zande J, Kulcsar A, Wellens HJ. Further observations to elucidate the role of interventricular dispersion of repolarization and early after depolarizations in the genesis of acquired torsade de pointes arrhythmias: A comparison between almokalant and d-sotalol using the dog as its own control. J Am Coll Cardiol. 1997;30:1575-84.
8. Chinushi M, Caref EB, Restivo M, Noll G, Aizawa Y, El-Sherif N. Cycle length-associated modulation of the regional dispersion of ventricular repolarization in a canine model of long QT syndrome. Pacing Clin Electrophysiol. 2001;24:1247-57.
9. Haapalahti P, Viitasalo M, Perhonen M, Mäkijärvi M, Väänänen H, Oikarinen L, et al. Ventricular repolarization and heart rate responses during cardiovascular autonomic function testing in LQT1 subtype of long QT syndrome. Pacing Clin Electrophysiol. 2006;29:1122-9.
10. Piippo K, Swan H, Pasternack M, Chapman H, Paavonen K, Viitasalo M, et al. A founder mutation of the potassium channel KCNQ1 in long QT syndrome: Implications for estimation of disease prevalence and molecular diagnostics. J Am Coll Cardiol. 2001;37:562-8.
11. Oikarinen L, Paavola M, Montonen J, Viitasalo M, Mäkijärvi M, Toivonen L, et al. Magnetocardiographic QT interval dispersion in postmyocardial infarction patients with sustained ventricular tachycardia: Validation of automated QT measurements. Pacing Clin Electrophysiol. 1998;21:1934-42.
12. Volders PGA, Stengl M, van Opstal JM, Gerlach U, Spatjens RLHMG, Beekman JDM, et al. Probing the contribution of IKs to canine ventricular repolarization: Key role for beta-adrenergic receptor stimulation. Circulation. 2003;107:2753-60.
13. Kandori A, Shimizu W, Yokokawa M, Maruo T, Kanzaki H, Nakatani S, et al. Detection of spatial repolarization abnormalities in patients with LQT1 and LQT2 forms of congenital long-QT syndrome. Physiol Meas. 2002;23:603-14.
14. Taggart P, Sutton P, Lab M, Dean J, Harrison F. Interplay between adrenaline and interbeat interval on ventricular repolarisation in intact heart in vivo. Cardiovasc Res. 1990;24:884-95.
15. Cooke WH, Carter JR, Kuusela TA. Muscle sympathetic nerve activation during the Valsalva maneuver: Interpretive and analytical caveats. Aviat Space Environ Med. 2003;74:731-7.
16. Abildskov JA. Adrenergic effects of the QT interval of the electrocardiogram. Am Heart J. 1976;92:210-6.
17. Taggart P, Sutton P, John R, Lab M, Swanton H. Monophasic action potential recordings during acute changes in ventricular loading induced by the Valsalva manoeuvre. Br Heart J. 1992;67:221-9.
18. Mitsutake A, Takeshita A, Kuroiwa A, Nakamura M. Usefulness of the Valsalva maneuver in management of the long QT syndrome. Circulation. 1981;63:1029-35.
19. Shimizu W, Antzelevitch C. Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes. Circulation. 1998;98:2314-22.
20. Viitasalo M, Oikarinen L, Swan H, Väänänen H, Glatter K, Laitinen PJ, et al. Ambulatory electrocardiographic evidence of transmural dispersion of repolarization in patients with long-QT syndrome type 1 and 2. Circulation. 2002;106:2473-8.