Misclassification of allele CYP2C19*10 as CY2C19*2 by a commonly used PCR-RFLP procedure

Genetic Testing

Volumn 12, Issue 1, 2008, Pages 57-58

  Rasmussen, Henrik ^a   Werge, Thomas ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2C19;

ALLELE; GENE FREQUENCY; GENE IDENTIFICATION; GENE MUTATION; GENETIC ANALYSIS; GENOTYPE; HETEROZYGOTE; LETTER; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ALLELES; ARYL HYDROCARBON HYDROXYLASES; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; GENOTYPE; HUMANS; MIXED FUNCTION OXYGENASES; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 41449116171     PISSN: 10906576     EISSN: None     Source Type: Journal    
DOI: 10.1089/gte.2007.0055     Document Type: Letter

References (7)

1. Blaisdell J, Mohrenweiser H, Jackson J, Ferguson S, Coulter S, Chanas B, Xi T, Ghanayem B, Goldstein JA (2002) Identification and functional characterization of new potentially defective alleles of human CYP2C19. Pharmacogenetics 12:703-711.
2. Daly AK, King BP, Leathart JB (2006) Genotyping for cytochrome P450 polymorphisms. Methods Mol Biol 320:193-207.
3. de Morais SM, Wilkinson GR, Blaisdell J, Nakamura K, Meyer UA, Goldstein JA (1994) The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem 269:15419-15422.
4. Desta Z, Zhao X, Shin JG, Flockhart DA (2002) Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin Pharmacokinet 41:913-958.
5. Goldstein JA, Blaisdell J (1996) Genetic tests which identify the principal defects in CYP2C19 responsible for the polymorphism in mephenytoin metabolism. Methods Enzymol 272:210-218.
6. Goldstein JA, Ishizaki T, Chiba K, de Morais SM, Bell D, Krahn PM, Evans DA (1997) Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations. Pharmacogenetics 7:59-64.
7. Yusuf I, Djojosubroto MW, Ikawati R, Lum K, Kaneko A, Marzuki S (2003) Ethnic and geographical distributions of CYP2C19 alleles in the populations of Southeast Asia. Adv Exp Med Biol 531:37-46.