Designing of substrates and inhibitors of bovine α-chymotrypsin with synthetic phenylalanine analogues in position P1

Protein and Peptide Letters

Volumn 15, Issue 3, 2008, Pages 260-264

  Wysocka, Magdalena ^a   Lesner, Adam ^a   Łȩgowska, Anna ^a   Jaśkiewicz, Anna ^a   Miecznikowska, Hanna ^a   Rolka, Krzysztof ^a  

^a UNIVERSITY OF GDA SK   (Poland)

Author keywords

Chromogenic substrate; Chymotrypsin; Peptide aldehyde; Peptidomimetic

Indexed keywords

CHYMOTRYPSIN; CHYMOTRYPSIN A; DRUG DERIVATIVE; ENZYME INHIBITOR; PHENYLALANINE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CATTLE; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; KINETICS; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; CHYMOTRYPSIN; ENZYME INHIBITORS; KINETICS; MOLECULAR SEQUENCE DATA; PHENYLALANINE; SUBSTRATE SPECIFICITY;

BOVINAE;

EID: 41449114126     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986608783744180     Document Type: Article

References (16)

1. Schechter, I., Berger, A., (1967) Biochem Biophys Res Commun., 27, 157.
2. Hof, P., Mayr, I., Huber, R., Korzus, E., Potempa, J., Travis, J., Powers, J.C. and Bode, W. (1996) EMBO J., 15, 5481.
3. Schellenberger, V., Braune, K., Hofmann, H.-J. and Jakubke, H.-D. (1991) Eur. J. Biochem., 199, 623.
4. McBride, J.D., Frejman, H.N., Domingo, G.J., Leatherbarrow, R.J. (1996) J. Mol. Biol, 259, 819.
5. Lu, W., Apostol, I., Qasim, M.A., Warne, N., Wynn, R., Hang, W.L., Anderson, S., Chiang, Y.W., Ogin, E., Rottenberg, I., Ryan, K. and Laskowski, M. Jr., (1997) J. Mol. Biol, 266, 441.
6. Krowarsch, D., Dadlez, M., Buczek, O., Krokoszynska, I., Smalas, A.O. and Otlewski, J. (1999) J. Mol. Biol., 289, 175.
7. Czapinska, H., Helland, R., Smalas, A.O. and Otlewski, J. (2004), J. Mol. Biol., 344, 1005.
8. Nery, E.D., Alves, L.C., Melo, R.L., Cesari, M.H.S., Juliano, L. and Juliano, M.A. (2000) J. Prot. Chem, 19, 33.
9. Gouvea, I.E., Izidoro, M.A., Judice, W.A.S., Cesari, M.H.S., Caliendo, G., Santagada, V., Dos Santos, C.N.D., Queiroz, M.H., Juliano, M.A., Young, P.R., Fairlie, D.P. and Juliano, L. (2007), Arch. Biochem. Biophys., 457, 187.
10. Fehrentz, J.-A., Paris, M., Hertz, A., Velek, J., Liu, C.-F., Winternitz, F. and Martinem, J. (1995) Tetrahedron Lett., 36, 7871.
11. Kaźmierczak, K., Zabłotna, E., Jaśkiewicz, A., Miecznikowska H. and Rolka, K. (2003) Biochem. Biophys.Res. Commun., 310, 811.
12. Hojo, K., Maeda, M., Iguchi, S. Smith, T., Okamoto, H. and Kawasaki, K.(2000) Chem. Pharm. Bull., 48, 1740.
13. Sole, N. A. Barany, G. (1992), J. Org. Chem., 57, 5399.
14. Lesner, A., Brzozowski, K., Kupryszewski, G. and Rolka, K. (2000) Biochem. Biophys.Res. Commun., 269, 81.
15. Lesner, A., Kupryszewski, G. and Rolka, K. (2001) Biochem. Biophys. Res. Commun., 285, 1350.
16. Wysocka, M., Kwiatkowska, B., Rzadkiewicz M., Lesner A. and Rolka K. (2007) Comb. Chem. High Trough. Screen., 3, 171.