Assessment of cytogenetic effect of antiblastic therapy by means of micronucleus assay in exfoliated epithelial cells

Gene Therapy and Molecular Biology

Volumn 11, Issue 2, 2007, Pages 177-184

  Nersesyan, Armen K ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Chemotherapy; Exfoliated cells; Micronucleus assay; Radiotherapy

Indexed keywords

EID: 41449096216     PISSN: 15299120     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (44)

1. Angelieri F, de Oliveira GR, Sannomiya EK, Ribeiro DA (2007) DNA damage and cellular death in oral mucosa cells of children who have undergone panoramic dental radiography. Pediatr Radiol 37, 561-565.
2. Bhattathiri NV, Bharathykkutty C, Prathapan R, Chirayathmanjiyil DA, Nair KM (1998b) Prediction of radiosensitivity of oral cancers by serial cytological assay of nuclear changes. Radiother Oncol 49, 61-65.
3. Bhattathiri NV, Bindu L, Remani P, Chandralekha B, Nair KM (1998a) Radiation-induced acute immediate nuclear abnormalities in oral cancer cells: serial cytologic evaluation. Acta Cytol 42, 1084-1090.
4. Bindu L, Balaram P, Mathew A, Remani P, Bhattathiri VN, Nair MK (2003) Radiation-induced changes in oral carcinoma cells - a multiparametric evaluation. Cytopathology 14, 287-293.
5. Burgaz S, Karahalil B, Bayrak P, Taskin L, Yavuzaslan F, Bokesoy I, Anzion RB, Bos RP, Platin N (1999) Urinary cyclophosphamide excretion and micronuclei frequencies in peripheral lymphocytes and in exfoliated buccal epithelial cells of nurses handling antineoplastics. Mutat Res 439, 97-104.
6. Cairns J (1975a) The cancer problem. Sci Am 233, 64-72.
7. Cairns J (1975b) Mutation selection and the natural history of cancer. Nature 255, 197-200.
8. Cao J, Liu Y, Sun H, Cheng G, Pang X, Zhou Z (2002) Chromosomal aberrations, DNA strand breaks and gene mutations in nasopharyngeal cancer patients undergoing radiation therapy. Mutat Res 504, 85-90.
9. Casartelli G, Monteghirfo S, De Ferrari M, Bonatti S, Scala M, Toma S, Margarino G, Abbondandolo A (1997) Staining of micronuclei in squamous epithelial cells of human oral mucosa. Anal Quant Cytol Histol 19, 475-481.
10. Cavallo D, Ursini CL, Omodeo-Sale E, Iavicoli S (2007) Micronucleus induction and FISH analysis in buccal cells and lymphocytes of nurses administering antineoplastic drugs. Mutat Res 628, 11-18.
11. Cavallo D, Ursini CL, Perniconi B, Francesco AD, Giglio M, Rubino FM, Marinaccio A, Iavicoli S (2005) Evaluation of genotoxic effects induced by exposure to antineoplastic drugs in lymphocytes and exfoliated buccal cells of oncology nurses and pharmacy employees. Mutat Res 587, 45-51.
12. Cerqueira EM, Gomes-Filho IS, Trindade S, Lopes MA, Passos JS, Machado-Santelli GM (2004) Genetic damage in exfoliated cells from oral mucosa of individuals exposed to X-rays during panoramic dental radiographies. Mutat Res 562, 111-117.
13. de Almeida TM, Leitao RC, rade JD, Becak W, Carrilho FJ, Sonohara S ( 2004) Detection of micronuclei formation and nuclear anomalies in regenerative nodules of human cirrhotic livers and relationship to hepatocellular carcinoma. Cancer Genet Cytogenet 150, 16-21.
14. Guzman P, Sotelo-Regil RC, Mohar A, Gonsebatt ME (2003) Positive correlation between the frequency of micronucleated cells and dysplasia in Papanicolaou smears. Environ Mol Mutagen 41, 339-343.
15. Kopjar N, Garaj-Vrhovac V, Milas I (2002) Acute cytogenetic effects of antineoplastic drugs in peripheral blood lymphocytes in cancer patients chromosome aberrations and micronuclei. Tumori 88, 300-312.
16. Kutsuki S, Ihara N, Shigematsu N, Okamoto S, Kubo A (2005) Relation between chromosomal aberrations and radiation dose during the process of TBI). Radiat Med 23, 37-42.
17. Lee R, Yamada S, Yamamoto N, Miyamoto T, Ando K, Durante M, Tsujii H ( 2004) Chromosomal aberrations in lymphocytes of lung cancer patients treated with carbon ions. J Radiat Res (Tokyo) 45, 195-199.
18. Machado-Santelli GM, Cerqueira EM, Oliveira CT, Pereira CA (1994) Biomonitoring of nurses handling antineoplastic drugs. Mutat Res 322, 203-8.
19. Majer BJ, Laky B, Knasmuller S, Kassie F (2002) Use of the micronucleus assay with exfoliated epithelial cells as a biomarker for monitoring individuals at elevated risk of genetic damage and in chemoprevention trials. Mutat Res 489, 147-72.
20. Mehrotra R, Goel N, Singh M, Kumar D (2004b) Radiation-related cytological changes in oral malignant cells. Indian J Pathol Microbiol 47, 343-347.
21. Mehrotra R, Gupta A, Singh M, Ibrahim R (2006) Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions. Mol Cancer 23, 5-11.
22. Mehrotra R, Madhu, Singh M (2004a) Serial scrape smear cytology of radiation response in normal and malignant cells of oral cavity. Indian J Pathol Microbiol 47, 497-502.
23. Minicucci EM, Kowalski LP, Maia MA, Pereira A, Ribeiro LR, de Camargo JL, Salvadori DM (2005) Cytogenetic damage in circulating lymphocytes and buccal mucosa cells of head-and-neck cancer patients undergoing radiotherapy. Radiat Res (Tokyo) 46, 135-142.
24. Nersesian AK (1996) The micronucleus test in human exfoliative cells as a method for studying the action of mutagens/carcinogens. Tsitol Genet 30, 91-96.
25. Nersesian AK, Zil'fian VN, Kumkumadzhian VA, Nersesian AK (1993) An analysis of the micronuclei in the oral mucosa of cancer patients for assessing the clastogenic effect of chemical preparations. Tsitol Genet 27, 77-80.
26. Nersesyan A, Kundi M, Atefie K, Schulte-Hermann R, Knasmuller S (2006) Effect of staining procedures on the results of micronucleus assays with exfoliated oral mucosa cells. Cancer Epidemiol Biomarkers Prev 15, 1835-40.
27. Nersesyan AK (1994) The study of micronuclei frequency in buceal mucosa cells of oral cancer patients under radiotherapy. In: Proc. of XVI Intern. Cancer Congress, New Delhi, India, R.S.Rao (Ed.), Monduzzi Editore, Bologna, pp. 95-98.
28. Nersesyan AK (2001) Letter to Editor. Carcinogenesis 22, 679.
29. Nersesyan AK (2005) Nuclear buds in exfoliated human cells. Mutat Res 588, 64-68.
30. Nersesyan AK (2005) Strange phenomenon, i.e., an antimutagenic effect of areca nut chewing. Mutat Res 582, 163-4.
31. Nersesyan AK (2006) The nature of "broken egg" events in exfoliated human cells. Acta Cytol 50, 598-589.
32. Odio AD, Duharte AB, Carnesoltas D, Garcia L, Loaces EL, Cabrera LG ( 2004) Cytogenetis effect of occupational exposure to cytostatics. Rec Med IMSS 42, 487-492.
33. Rimpu K, Arun C, Goyal PK (2005) Karyoanomalic frequency during radiation therapy. J Cancer Res Ther 1, 187-190.
34. Sarto F, Tomanin R, Giacomelli L, Canova A, Raimondi F, Ghiotto C, Fiorentino MV (1990) Evaluation of chromosomal aberrations in lymphocytes and micronuclei in lymphocytes, oral mucosa and hair root cells of patients under antiblastic therapy. Mutat Res 228, 157-169.
35. Schlomm T, Gunawan B, Schulten HJ, Sander B, Thangavelu K, Graf N, Leuschner I, Ringert RH, Fuzesi L (2005) Effects of chemotherapy on the cytogenetic constitution of Wilms' tumor. Clin Cancer Res 11, 4382-4387.
36. Silva LM, Takahashi CS, Carrara HH (2002) Study of chromosome damage in patients with breast cancer treated by two antineoplastic treatments. Teratog Carcinog Mutagen 22, 257-269.
37. Singh S, Datta NR, Krishnani N, Lal P, Kumar S (2005) Radiation therapy induced micronuclei in cervical cancer - does it have a predictive value for local disease control? Gynecol Oncol 97, 764-771.
38. Tolbert PE, Shy CM, Allen JW (1991) Micronuclei and other nuclear anomalies in buccal smears: a field test in snuff users. Am J Epidemiol 134, 840-850.
39. Torres-Bugarin O, De Anda-Casillas A, Ramirez-Munoz MP, Sanchez-Corona J, Cantu JM, Zuniga G (1998) Determination of diesel genotoxicity in firebreathers by micronuclei and nuclear abnormalities in buccal mucosa. Mutat Res 413, 277-281.
40. Torres-Bugarin O, Ventura-Aguilar A, Zamora-Perez A, Gomez-Meda BC, Ramos-Ibarra ML, Morga-Villela G, Gutierrez-Franco A, Zuniga-Gonzalez G (2004) Evaluation of cisplatin + 5-FU, carboplatin + 5-FU, ifosfamide + epirubicine regimens using the micronuclei test and nuclear abnormalities in the buccal mucosa. Mutat Res 565, 91-101.
41. Vartazaryan NS (2003) Investigation of cytogenetic disturbances in exfoliated human cells by means of micronucleus assay. PhD thesis. State University, Yerevan, Armenia.
42. Widel M, Jedrus S, Owczarek S, Konopacka M, Lubecka B, Kolosza Z ( 1999) The increment of micronucleus frequency in cervical carcinoma during irradiation in vivo and its prognostic value for tumour radiocurability. Br J Cancer 80, 1599-1607.
43. Widel M, Kolosza Z, Jedrus S, Lukaszczyk B, Raczek-Zwierzycka K, Swierniak A (2001) Micronucleus assay in vivo provides significant prognostic information in human cervical carcinoma; the updated analysis. Int J Radiat Biol 77, 631-636.
44. Yin CC, Glassman AB, Lin P, Valbuena JR, Jones D, Luthra R, Medeiros LJ (2005) Morphologic, cytogenetic, molecular abnormalities in therapy-related acute promyelocytic leukaemia. Am J Clin Pathol 123, 840-848.