Cattle protected from onchocerciasis by ivermectin are highly susceptible to infection after drug withdrawal

International Journal for Parasitology

Volumn 34, Issue 9, 2004, Pages 1069-1074

  Njongmeta, L M ^a   Nfon, C K ^a,b   Gilbert, J ^a   Makepeace, B L ^a   Tanya, V N ^b   Trees, A J ^a  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^b Regional Centre of Wakwa   (Cameroon)

Author keywords

Cattle; Chemoprophylaxis; Immunity; Ivermectin; Onchocerca ochengi; Onchocerciasis

Indexed keywords

IVERMECTIN; MOXIDECTIN;

CATTLE; IMMUNITY; IVERMECTIN; ONCHOCERCIASIS; PARASITE CONTROL;

ANIMAL EXPERIMENT; ARTICLE; CATTLE; CONTROLLED STUDY; ENDEMIC DISEASE; EXPERIMENTAL INFECTION; FEMALE; GEOMETRY; IMMUNE RESPONSE; INFECTION SENSITIVITY; IRRADIATION; MICROFILARIA; NODULATION; NONHUMAN; ONCHOCERCA; ONCHOCERCA OCHENGI; ONCHOCERCIASIS; PARASITE TRANSMISSION; PREVALENCE; STATISTICAL SIGNIFICANCE;

ANIMALS; CATTLE; CATTLE DISEASES; DISEASE SUSCEPTIBILITY; DRUG ADMINISTRATION SCHEDULE; FILARICIDES; IVERMECTIN; MICROFILARIA; ONCHOCERCIASIS; PROSPECTIVE STUDIES;

AFRICA;

ANIMALIA; BOS TAURUS; ONCHOCERCA; ONCHOCERCA OCHENGI; ONCHOCERCA VOLVULUS;

EID: 4143142020     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2004.04.011     Document Type: Article

References (25)

1. Blair S., Campbell W. Immunization of ferrets against Dirofilaria immitis by means of chemically abbreviated infections. Parasite Immunol. 3:1981;143-147
2. Borsboom G.J.J.M., Boatin B.A., Nagelkerke N.J.D., Agoua H., Akpoboua K.L.B., Alley E.W.S., Bissan Y., Renz A., Yameogo L., Remme J.H.F., Habbema J.D.F. Impact of ivermectin on onchocerciasis transmission: assessing the empirical evidence that repeated ivermectin mass treatments may lead to elimination/eradication in West Africa. Filaria J. 2:2003;8
3. Boussinesq M., Chippaux J.-P. A controlled prospective trial of the prophylactic effect of a single dose of ivermectin against Onchocerca volvulus. Parasite. 8:2001;255-259
4. Boussinesq M., Prod'hon J., Chippaux J.-P. Onchocerca volvulus: striking decrease in transmission in the Vina Valley (Cameroon) after eight annual large scale ivermectin treatments. Trans. R. Soc. Trop. Med. Hyg. 91:1997;82-86
5. Burnham G. Onchocerciasis. Lancet. 351:1998;1341-1346
6. Dadzie Y., Neira M., Hopkins D. Final report of the Conference on the Eradicability of Onchocerciasis. Filaria J. 2:2003;2
7. Duerr H.P., Dietz K., Schulz-Key H., Büttner D.W., Eichner M. Density-dependent parasite establishment suggests infection-associated immunosuppression as an important mechanism for parasite density regulation in onchocerciasis. Trans. R. Soc. Trop. Med. Hyg. 97:2003;242-250
8. Gardon J., Boussinesq M., Kamgno J., Gardon-Wendel N., Demanga N., Duke B.O.L. Effects of standard and high doses of ivermectin on adult worms of Onchocerca volvulus: a randomised controlled trial. Lancet. 360:2002;203-210
9. Graham S.P., Trees A.J., Collins R.A., Moor D.M., Guy F.M., Taylor M.J., Bianco A.E. Down-regulated lymphoproliferation coincides with parasite maturation and with the collapse of both gamma interferon and interleukin-4 responses in a bovine model of onchocerciasis. Infect. Immun. 69:2001;4313-4319
10. Grieve R.B., Abraham D., Mika-Grieve M., Seibert B.P. Induction of protective immunity in dogs to infection with Dirofilaria immitis using chemically-abbreviated infections. Am. J. Trop. Med. Hyg. 39:1988;373-379
11. Guderian R.H., Anselmi M., Espinel M., Mancero T., Rivadeneira G., Proaño R., Calvopiña H.M., Vieira J.C., Cooper P.J. Successful control of onchocerciasis with community-based ivermectin distribution in the Rio Santiago focus in Ecuador. Trop. Med. Int. Health. 2:1997;982-988
12. Langworthy N.G., Renz A., Mackenstedt U., Henkle-Dührsen K., Bronsvoort M.B.C., Tanya V.N., Donnelly M.J., Trees A.J. Macrofilaricidal activity of tetracycline against the filarial nematode Onchocerca ochengi: elimination of Wolbachia precedes worm death and suggests a dependent relationship. Proc. R. Soc. Lond. B Biol. Sci. 267:2000;1063-1069
13. Lanusse C., Lifschitz A., Virkel G., Alvarez L., Sánchez S., Sutra J.F., Galtier P., Alvinerie M. Comparative plasma disposition kinetics of ivermectin, moxidectin and doramectin in cattle. J. Vet. Pharmacol. Therap. 20:1997;91-99
14. Molyneux D.H. Onchocerciasis control in West Africa: current status and future of the Onchocerciasis Control Programme. Parasitol. Today. 11:1995;399-402
15. Molyneux D.H., Bradley M., Hoerauf A., Kyelem D., Taylor M.J. Mass drug treatment for lymphatic filariasis and onchocerciasis. Trends Parasitol. 19:2003;516-522
16. Plaisier A.P., van Oortmarssen G.J., Habbema J.D.F., Remme J., Alley E.S. ONCHOSIM: a model and computer simulation program for the transmission and control of onchocerciasis. Comput. Methods Programs Biomed. 31:1990;43-56
17. Renz A., Trees A.J., Achu-Kwi D., Edwards G., Wahl G. Evaluation of suramin, ivermectin and CGP 20376 in a new macrofilaricidal drug screen, Onchocerca ochengi in African cattle. Trop. Med. Parasitol. 46:1995;31-37
18. Richards F., Hopkins D., Cupp E. Programmatic goals and approaches to onchocerciasis. Lancet. 355:2000;1663-1664
19. Soboslay P.T., Luder C.G.K., Hoffmann W.H., Michaelis I., Helling G., Heuschkel C., Dreweck C.M., Blanke C.H., Pritze S., Banla M., Schulz-Key H. Ivermectin-facilitated immunity in onchocerciasis: activation of parasite-specific Th1-type responses with subclinical Onchocerca volvulus infection. Clin. Exp. Immunol. 96:1994;238-244
20. Tchakouté V.L., Bronsvoort M., Tanya V., Renz A., Trees A.J. Chemoprophylaxis of Onchocerca infections: in a controlled, prospective study ivermectin prevents calves becoming infected with O. ochengi. Parasitology. 118:1999;195-199
21. Wahl G., Enyong P., Ngosso A., Schibel J.M., Moyou R., Tubbesing H., Ekale D., Renz A. Onchocerca ochengi: epidemiological evidence of cross-protection against Onchocerca volvulus in man. Parasitology. 116:1998;349-362
22. Winnen M., Plaisier A.P., Alley E.S., Nagelkerke N.J.D., van Oortmarssen G., Boatin B.A., Habbema J.D.F. Can ivermectin mass treatments eliminate onchocerciasis in Africa? Bull. World Health Organ. 80:2002;384-390
23. WHO, 1995. Onchocerciasis and its control. World Health Organ. Tech. Rep. Ser. N°852.
24. WHO. A suitable macrofilaricide? TDR News. 62:2000;11
25. WHO. Onchocerciasis (river blindness): report from the 12th InterAmerican Conference on Onchocerciasis, Manaus, Brazil. Wkly. Epidemiol. Rec. 78:2003;361-364