Expression of the two nested overlapping reading frames of turnip yellow mosaic virus RNA is enhanced by a 5′ cap and by 5′ and 3′ viral sequences

Journal of Virology

Volumn 78, Issue 17, 2004, Pages 9325-9335

  Matsuda, Daiki ^a   Bauer, Lisa ^a   Tinnesand, Kathryn ^a   Dreher, Theo W ^a  

^a OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; VIRUS RNA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; AMINOACYLATION; ARTICLE; CODON; GENE CONSTRUCT; GENE DELETION; GENE EXPRESSION REGULATION; MOLECULAR BIOLOGY; NONHUMAN; OPEN READING FRAME; OVERLAPPING READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ANALYSIS; SEQUENCE ANALYSIS; START CODON; TRANSCRIPTION INITIATION SITE; TURNIP; TURNIP YELLOW MOSAIC VIRUS;

3' UNTRANSLATED REGIONS; 5' UNTRANSLATED REGIONS; AMINO ACID SEQUENCE; BASE SEQUENCE; CODON, INITIATOR; FABACEAE; GENE EXPRESSION REGULATION, VIRAL; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; PROTEIN BIOSYNTHESIS; PROTOPLASTS; RNA CAPS; RNA, VIRAL; SEQUENCE DELETION; TYMOVIRUS; UNTRANSLATED REGIONS;

EID: 4143129900     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.78.17.9325-9335.2004     Document Type: Article

References (26)

1. Barends, S., H. H. Sink, S. H. van den Worm, C. W. Pleij, and B. Kraal. 2003. Entrapping ribosomes for viral translation: tRNA mimicry as a molecular Trojan horse. Cell 112:123-129.
2. Drageon, G., and I. Jupin. 2002. Stability in vitro of the 69K movement protein of Turnip yellow mosaic virus is regulated by the ubiquitin-mediated proteasome pathway. J. Gen. Virol. 83:3187-3197.
3. Fajardo, J. E., and A. J. Shatkin. 1990. Translation of bicistronic viral mRNA in transfected cells: regulation at the level of elongation. Proc. Natl. Acad. Sci. USA 87:328-332.
4. Gallic, D. R. 2002. The 5′-leader of tobacco mosaic virus promotes translation through enhanced recruitment of eIF4F. Nucleic Acids Res. 30:3401-3411.
5. Gallic, D. R. 1991. The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency. Genes Dev. 5:2108-2116.
6. Gallic, D. R., and M. Kobayashi. 1994. The role of the 3′-untranslated region of non-polyadenylated plant viral mRNAs in regulating translational efficiency. Gene 142:159-165.
7. Gallic, D. R., D. E. Sleat, J. W. Watts, P. C. Turner, and T. M. Wilson. 1987. The 5′-leader sequence of tobacco mosaic virus RNA enhances the expression of foreign gene transcripts in vitro and in vivo. Nucleic Acids Res. 15:3257-3273.
8. Gallic, D. R., D. E. Sleat, J. W. Watts, P. C. Turner, and T. M. Wilson. 1987. A comparison of eukaryotic viral 5′-leader sequences as enhancers of mRNA expression in vivo. Nucleic Acids Res. 15:8693-8711.
9. Hellendoorn, K., P. J. Michiels, R. Buitenhuis, and C. W. Pleij. 1996. Protonatable hairpins are conserved in the 5′-untranslated region of tymovirus RNAs. Nucleic Acids Res. 24:4910-4917.
10. Hellendoorn, K., P. W. Verlaan, and C. W. Plerj. 1997. A functional role for the conserved protonatable hairpins in the 5′ untranslated region of turnip yellow mosaic virus RNA. J. Virol. 71:8774-8779.
11. Jobling, S. A., and L. Gehrke. 1987. Enhanced translation of chimaeric messenger RNAs containing a plant viral untranslated leader sequence. Nature 325:622-625.
12. Kozak, M. 1995. Adherence to the first-AUG rule when a second AUG codon follows closely upon the first. Proc. Natl. Acad. Sci. USA 92:2662-2666.
13. Kozak, M. 1999. Initiation of translation in prokaryotes and eukaryotes. Gene 234:187-208.
14. Kozak, M. 1991. A short leader sequence impairs the fidelity of initiation by eukaryotic ribosomes. Gene Expr. 1:111-115.
15. Lukaszewicz, M., M. Feuermann, B. Jerouville, A. Stas, and M. Boutry. 2000. In vivo evaluation of the context sequence of the translation initiation codon in plants. Plant Sci. 154:89-98.
16. Mangus, D. A., M. C. Evans, and A. Jacobson. 2003. Poly(A)-binding proteins: multifunctional scaffolds for the posttranscriptional control of gene expression. Genome Biol. 4:223.
17. Matsuda, D., and T. W. Dreher. 2004. The tRNA-like structure of Turnip yellow mosaic virus RNA in a 3′-translational enhancer. Virology 321:36-46.
18. Pestova, T. V., V. G. Kolupaeva, I. B. Lomakin, E. V. Pilipenko, I. N. Shatsky, V. I. Agol, and C. U. Hellen. 2001. Molecular mechanisms of translation initiation in eukaryotes. Proc. Natl. Acad. Sci. USA 98:7029-7036.
19. Sachs, A. B., P. Sarnow, and M. W. Hentze. 1997. Starting at the beginning, middle, and end: translation initiation in eukaryotes. Cell 89:831-838.
20. Sarnow, P. 2003. Viral internal ribosome entry site elements: novel ribosome-RNA complexes and roles in viral pathogenesis. J. Virol. 77:2801-2806.
21. Tomashevskaya, O., A. Solovyev, O. Karpova, O. Fedorkin, N. Rodionova, S. Morozov, and J. Atabekov. 1993. Effects of sequence elements in the potato virus X RNA 5′ non-translated alpha beta-leader on its translation enhancing activity. J. Gen. Virol. 74:2717-2724.
22. Turner, R. L., M. Glynn, S. C. Taylor, M. K. Cheung, C. Spurr, D. Twell, and G. D. Foster. 1999. Analysis of a translational enhancer present within the 5′-terminal sequence of the genomic RNA of potato virus S. Arch. Virol. 144:1451-1461.
23. Vende, P., M. Piron, N. Castagne, and D. Poncet. 2000. Efficient translation of rotavirus mRNA requires simultaneous interaction of NSP3 with the eukaryotic translation initiation factor eIF4G and the mRNA 3′ end. J. Virol. 74:7064-7071.
24. Weiland, J. J., and T. W. Dreher. 1989. Infectious TYMV RNA from cloned cDNA: effects in vitro and in vivo of point substitutions in the initiation codons of two extensively overlapping ORFs. Nucleic Acids Res. 17:4675-4687.
25. Wells, D. R., R. L. Tanguav, H. Le, and D. R. Gallie. 1998. HSP101 functions as a specific translational regulatory protein whose activity is regulated by nutrient status. Genes Dev. 12:3236-3251.
26. Williams, M. A., and R. A. Lamb. 1989. Effect of mutations and deletions in a bicistronic mRNA on the synthesis of influenza B virus NB and NA glycoproteins. J. Virol. 63:28-35.