Protective effect of an oral endothelin converting enzyme inhibitor on rat detrusor function after outlet obstruction

Journal of Urology

Volumn 172, Issue 3, 2004, Pages 1171-1174

  Schröder, Annette ^a   Tajimi, Masaomi ^b   Matsumoto, Hiroko ^b   Schröder, Christian ^c   Brands, Michael ^c   Andersson, Karl Erik ^a,c  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b BAYER YAKUHIN LTD   (Japan)

^c BAYER AG   (Germany)

Author keywords

Bladder; Bladder neck obstruction; Endothelin; Hypertrophy; Muscle, smooth

Indexed keywords

ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN CONVERTING ENZYME INHIBITOR; UNCLASSIFIED DRUG; VASOCONSTRICTOR AGENT; WO 03028719;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER CONTRACTION; BLADDER NECK STENOSIS; CONTROLLED STUDY; CYSTOMETRY; DETRUSOR MUSCLE; DRUG EFFECT; FEMALE; MICTURITION; MUSCLE GROWTH; NONHUMAN; PRIORITY JOURNAL; RAT; RESIDUAL URINE; SMOOTH MUSCLE;

EID: 4143124477     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000133561.32285.23     Document Type: Article

References (20)

1. Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y. et al: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature, 332: 411, 1988
2. Garcia-Pascual, A., Larsson, B. and Andersson, K. E.: Contractile effects of endothelin-1 and localization of endothelin binding sites in rabbit lower urinary tract smooth muscle. Acta Physiol Scand, 140: 545, 1990
3. Okamoto-Koizumi, T., Takeda, M., Komeyama, T., Hatano, A., Tamaki, M., Mizusawa, T. et al: Pharmacological and molecular biological evidence for ETA endothelin receptor subtype mediating mechanical responses in the detrusor smooth muscle of the human urinary bladder. Clin Sci, 96: 397, 1999
4. Khan, M. A., Dashwood, M. R., Thompson, C. S., Mumtaz, F. H., Mikhailidis, D. P. and Morgan, R. J.: Up-regulation of endothelin (ET(A) and ET(B)) receptors and down- regulation of nitric oxide synthase in the detrusor of a rabbit model of partial bladder outlet obstruction. Urol Res, 27: 445, 1999
5. Rossi, G. P., Albertin, G., Franchin, E., Sacchetto, A., Cesari, M., Palu, G. et al: Expression of the endothelin-converting enzyme gene in human tissues. Biochem Biophys Res Commun, 211: 249, 1995
6. Saenz de Tejada, I., Mueller, J. D., De Las Morenas, A., Machado, M., Moreland, R. B., Krane, R. J. et al: Endothelin in the urinary bladder. I. Synthesis of endothelin-1 by epithelia, smooth muscle and fibroblasts suggests autocrine and paracrine cellular regulation J Urol, 148: 1290, 1992
7. Khan, M. A., Shukla, N., Auld, J., Thompson, C. S., Mumtaz, F. H., Stansby, G. P. et al: Possible role of endothelin-1 in the rabbit urinary bladder hyperplasia secondary to partial bladder outlet obstruction. Scand J Urol Nephrol, 34: 15, 2000
8. Emoto, N. and Yanagisawa, M.: Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. J Biol Chem, 270: 15262, 1995
9. Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., deWit, D. et al: ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell, 78: 473, 1994
10. Ikeda, S., Emoto, N., Alimsardjono, H., Yokoyama, M. and Matsuo, M.: Molecular isolation and characterization of novel four subisoforms of ECE-2. Biochem Biophys Res Commun, 293: 421, 2002
11. Yanagisawa, H., Hammer, R. E., Richardson, J. A., Emoto, N., Williams, S. C., Takeda, S. et al: Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development. J Clin Invest, 105: 1373, 2000
12. Hanson, G. C., Wide-Swenson, D., Andersson, K. E. and Lindberg, B. F.: Conversion of big endothelin-1 and characterization of its contractile effects on isolated human placental arteries. Gynecol Obstet Invest, 45: 1, 1998
13. Gratton, J. P., Maurice, M. C. Rae, G. A. and D'Orleans-Juste, P.: Pharmacological properties of endothelins and big endothelins in ketamine/xylazine or urethane anesthetized rats. Am J Hypertens, 8: 1121, 1995
14. Schröder, A., Chichester, P., Kogan, B. A., Longhurst, P. A., Lieb, J., Das, A. K. et al: Effect of chronic bladder outlet obstruction on blood flow of the rabbit bladder. J Urol, 165: 640, 2001
15. Greenland, J. E. and Brading, A. F.: The effect of bladder outflow obstruction on detrusor blood flow changes during the voiding cycle in conscious pigs. J Urol, 165: 245, 2001
16. Watanabe, T., Suzuki, N., Shimamoto, N., Fujino, M. and Imada, A.: Contribution of endogenous endothelin to the extension of myocardial infarct size in rats. Circ Res, 69: 370, 1991
17. Grover, G. J., Dzwonczyk, S. and Parham, C. S.: The endothelin-1 receptor antagonist BQ-123 reduces infarct size in a canine model of coronary occlusion and reperfusion. Cardiovasc Res, 27: 1613, 1993
18. Martin, P., Tzanidis, A., Stein-Oakley, A. and Krum, H.: Effect of a highly selective endothelin-converting enzyme inhibitor on cardiac remodeling in rats after myocardial infarction. J Cardiovasc Pharmacol, 36: S367, 2000
19. Levin, R. M., Malkowicz, S. B., Wein, A. J., Atta, M. A. and Elbadawi, A.: Recovery from short-term obstruction of the rabbit urinary bladder. J Urol, 134: 388, 1985
20. Gabella, G. and Uvelius, B.: Structural changes in the rat bladder after acute outlet obstruction. Scand J Urol Nephrol Suppl, 201: 32, 1999