Gonadal and erectile dysfunction in diabetics

Medical Clinics of North America

Volumn 88, Issue 4, 2004, Pages 933-945

  Hijazi, Rabih A ^a,b   Betancourt Albrecht, Marion ^a   Cunningham, Glenn R ^a,b,c  

^a MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Departments of Medicine   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; CYCLIC AMP; ESTROGEN; INSULIN; LEPTIN; LUTEINIZING HORMONE; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; PROLACTIN; PROSTAGLANDIN E1; SEX HORMONE BINDING GLOBULIN; SILDENAFIL; TADALAFIL; TESTOSTERONE; VARDENAFIL;

AGING; BODY MASS; CASTRATION; CLINICAL TRIAL; CORRELATION ANALYSIS; DIABETES MELLITUS; DIABETIC RETINOPATHY; DIZZINESS; DYSPEPSIA; ERECTILE DYSFUNCTION; FLUSHING; GLUCOSE TOLERANCE TEST; HEADACHE; HUMAN; HYPERINSULINISM; HYPOGONADISM; LONGITUDINAL STUDY; MUSCLE RELAXATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NOSE CONGESTION; OBESITY; PENIS ERECTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVIEW; RHINITIS; RISK FACTOR; SEX DIFFERENCE; SEXUAL BEHAVIOR; SIDE EFFECT; SMOKING HABIT; SYSTOLIC BLOOD PRESSURE; VACUUM; VISUAL DISORDER; WEIGHT REDUCTION;

AGE DISTRIBUTION; AGED; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; FOLLOW-UP STUDIES; HUMANS; HYPOGLYCEMIC AGENTS; HYPOGONADISM; IMPOTENCE; INCIDENCE; MALE; MIDDLE AGED; RISK ASSESSMENT; TESTOSTERONE; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 4143121381     PISSN: 00257125     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcna.2004.04.007     Document Type: Review

References (53)

1. Data and trends: diabetes surveillence system: prevalence of diagnosed diabetes by age, United States, 1980-2000. Available at: www.cdc.gov/diabetes/ statistics/prev/national/fig3.htm. Accessed May 18, 2004.
2. Mokdad A.H., Bowman B.A., Ford E.S., Vinicor F., Marks J.S., Koplan J.P. The continuing epidemics of obesity and diabetes in the United States. JAMA. 286:2001;1195-1200
3. Gallagher D., Ruts E., Visser M., Heshka S., Baumgartner R.N., Wang J., et al. Weight stability masks sarcopenia in elderly men and women. Am J Physiol. 279:2000;E366-E375
4. Ohlson L., Larsson B., Svardsudd K., Welin L., Eriksson H., Wilhelmsen L., et al. The influence of body fat distribution on the incidence of diabetes mellitus. 13.5 years of follow-up of the participants in the study of men born in 1913. Diabetes. 34:1985;1055-1058
5. Gray A., Feldman H.A., McKinlay J.B., Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab. 73:1991;1016-1025
6. Deslypere J.P., Vermeulen A. Leydig cell function in normal men: effect of age, life-style, residence, diet, and activity. J Clin Endocrinol Metab. 59:1984;955-962
7. Morley J.E., Charlton E., Patrick P., Kaiser F.E., Cadeau P., McCready D., et al. Validation of a screening questionnaire for androgen deficiency in aging males. Metabolism. 49:2000;1239-1242
8. Morley J.E., Kaiser F.E., Perry H.M. III, Patrick P., Morley P.M., Stauber P.M., et al. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism. 46:1997;410-413
9. Harman S.M., Metter E.J., Tobin J.D., Pearson J., Blackman M.R. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab. 86:2001;724-731
10. Feldman H.A., Longcope C., Derby C.A., Johannes C.B., Araujo A.B., Coviello A.D., et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab. 87:2002;589-598
11. Tenover J.S., Matsumoto A.M., Plymate S.R., Bremner W.J. The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate. J Clin Endocrinol Metab. 65:1987;1118-1126
12. Korenman S.G., Morley J.E., Mooradian A.D., Davis S.S., Kaiser F.E., Silver A.J., et al. Secondary hypogonadism in older men: its relation to impotence. J Clin Endocrinol Metab. 71:1990;963-969
13. Luboshitzky R., Shen-Orr Z., Herer P. Middle-aged men secrete less testosterone at night than young healthy men. J Clin Endocrinol Metab. 88:2003;3160-3166
14. Haffner S.M., Shaten J., Stern M.P., Smith G.D., Kuller L., for the MRFIT Research Group. Low levels of sex hormone-binding globulin and testosterone predict the development of non-insulin-dependent diabetes mellitus in men. Multiple Risk Factor Intervention Trial. Am J Epidemiol. 143:1996;889-897
15. Oh J.Y., Barrett-Connor E., Wedick N.M., Wingard D.L. Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo Study. Diabetes Care. 25:2002;55-60
16. Stellato R.K., Feldman H.A., Hamdy O., Horton E.S., McKinlay J.B. Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts Male Aging Study. Diabetes Care. 23:2000;490-494
17. Barrett-Connor E., Khaw K.T., Yen S.S. Endogenous sex hormone levels in older adult men with diabetes mellitus. Am J Epidemiol. 132:1990;895-901
18. Barrett-Connor E. Lower endogenous androgen levels and dyslipidemia in men with non-insulin-dependent diabetes mellitus. Ann Intern Med. 117:1992;807-811
19. Tan R.S., Pu S.J. Impact of obesity on hypogonadism in the andropause. Int J Androl. 25:2002;195-201
20. Goodman-Gruen D., Barret-Connor E. Sex differences in the association of endogenous sex hormone levels and glucose tolerance status in older men and women. Diabetes Care. 23:2000;912-918
21. Couillard C., Gagnon J., Bergeron J., Leon A.S., Rao D.C., Skinner J.S., et al. Contribution of body fatness and adipose tissue distribution to the age variation in plasma steroid hormone concentrations in men: the HERITAGE Family Study. J Clin Endocrinol Metab. 85:2000;1026-1031
22. Abate N., Haffner M., Garg A., Peshock R., Grundy S. Sex steroid-hormones, upper body obesity and insulin resistance. J Clin Endocrinol Metab. 87:2002;4522-4527
23. Phillips G.B., Jing T., Heymsfield S.B. Relationships in men of sex hormones, insulin, adiposity, and risk factors for myocardial infarction. Metabolism. 52:2003;784-790
24. Plymate S.R., Jones R.E., Matej L.A., Friedl K.E. Regulation of sex hormone binding globulin (SHBG) production in Hep G2 cells by insulin. Steroids. 52:1988;339-340
25. Anderson D.C. Sex-hormone-binding globulin. Clin Endocrinol. 3:1974;69-96
26. Lovejoy J.C., Smith S.R., Bray G.A., Veldhuis J.D., Rood J.C., Tulley R. Effects of experimentally induced mild hyperthyroidism on growth hormone and insulin secretion and sex steroid levels in healthy young men. Metabolism. 46:1997;1424-1428
27. Motta E. Epilepsy and hormones. Neurol Neurochir Pol. 33:(Suppl 1):2000;S31-S36
28. Adlercreutz H., Hockerstedt K., Bannwart C., Bloigu S., Hamalainen E., Fotsis T., et al. Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG). J Steroid Biochem Mol Biol. 27:1987;1135-1144
29. Selby C. Sex hormone binding globulin: origin, function and clinical significance. Ann Clin Biochem. 27:1990;532-541
30. Vermeulen A., Kaufman J.M., Deslypere J.P., Thomas G. Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men. J Clin Endocrinol Metab. 76:1993;1140-1146
31. Gapstur S.M., Gann P.H., Kopp P., Colangelo L., Longcope C., Liu K. Serum androgen concentrations in young men: a longitudinal analysis of associations with age, obesity, and race. The CARDIA male hormone study. Cancer Epidemiol Biomarkers Prev. 11:2002;1041-1047
32. Strain G.W., Zumoff B., Miller L.K., Rosner W., Levit C., Kalin M., et al. Effect of massive weight loss on hypothalamic-pituitary-gonadal function in obese men. J Clin Endocrinol Metab. 66:1988;1019-1023
33. Zumoff B., Strain G.W., Miller L.K., Rosner W., Levit C.D., Miller E.H., et al. Partial reversal of the hypogonadotropic hypogonadism of obese men by administration of corticosuppressive doses of dexamethasone. Int J Obes. 12:1988;525-531
34. Lima N., Cavaliere H., Knobel M., Halpern A., Medeiros-Neto G. Decreased androgen levels in massively obese men may be associated with impaired function of the gonadostat. Int J Obes. 24:2000;1433-1437
35. Frederich R.C., Hamann A., Anderson S., Lollmann B., Lowell B.B., Flier J.S. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med. 1:1995;1311-1314
36. Baumgartner R., Walters D., Morley J., Patrick P., Montoya G.D., Garry P.J. Age related changes in sex hormones affect the sex difference in serum leptin independently of changes in body fat. Metabolism. 48:1999;378-384
37. Vettor R., De Pergola G., Pagano C., Englaro P., Laudadio E., Giorgino F., et al. Gender differences in serum leptin in obese people:relationships with testosterone, body fat distribution and insulin sensitivity. Eur J Clin Invest. 27:1997;1016-1024
38. Nishizawa H., Shimomura I., Kishida K., Maeda N., Kuriyama H., Nagaretani H., et al. Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes. 51:2002;2734-2741
39. McCulloch D.K., Campbell I.W., Wy F.C., Prescott R.J., Clarke B.F. The prevalence of diabetic impotence. Diabetologia. 18:1980;279
40. Klein R., Klein B.E.K., Lee K.E., Moss S.E., Cruickshanks K.J. Prevalence of self-reported erectile dysfunction in people with long-term IDDM. Diabetes Care. 19:1996;135-141
41. Andersson K.E., Wagner G. Physiology of penile erection. Physiol Rev. 75:1995;191
42. Lue T.F. Erectile dysfunction. N Engl J Med. 342:2000;1802-1813
43. Miller M.A.W., Morgan R.J., Thompson C.S., Mikhailidis D.P., Jeremy J.Y. Hydrolysis of cyclic guanosine monophosphate and cyclic adenosine monophosphate by the penis and aorta of the diabetic rat. British Journal of Urology. 78:1996;252-256
44. Azad N., Emanuele N.V., Abraira, Henderson W.G., Colwell J., Levin S.R., et al. The effects of intensive glycemic control on neuropathy in the VA cooperative study on type II diabetes mellitus (VA CSDM). J Diabetes Complications. 13:1999;307-313
45. Rendell M.S., Rajfer J., Wicker P.A., Smith M.D., for the Sildenafil Diabetes Study Group. Sildenafil for treatment of erectile dysfunction in men with diabetes. A randomized controlled trial. JAMA. 281:1999;421-426
46. Goldstein I., Young J.M., Fischer J., Bangerter K., Segerson T., Taylor T., for the Vardenafil Diabetes Study Group. Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes. Diabetes Care. 26:2003;777-783
47. Saenz de Tejada I., Anglin G., Knight J.R., Emmick J.T. Effects of tadalafil on erectile dysfunction in men with diabetes. Diabetes Care. 25:2002;2159-2164
48. Linet O.I., Ogring F.G., for the Alprostadil Study Group. Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. NEJM. 334:1996;873-877
49. Padma-Nathan H., Hellstrom W.J.G., Kaiser F.E., Labasky R.F., Lue T.F., Nolton W.E., et al. Treatment of men with erectile dysfunction with transurethral alprostadil. N Engl J Med. 336:1997;1
50. Cookson M.S., Nadig P.W. Long-term results with vacuum constriction device. J Urol. 149:1993;290-294
51. Price D.E., Cooksey G., Jehu D., Bentley S., Hearnshow J.R., Osborn D.E. The management of impotence in diabetic men by vacuum tumescence therapy. Diabet Med. 8:1991;964-967
52. Kearse W.S., Sago A.L., Peretsman S.J., Bolton J.O., Holcomb R.G., Reddy P.K., et al. Report of a multicenter clinical evaluation of the Dura-II penile prosthesis. J Urol. 334:1996;873
53. Garber B.B. Inflatable penile prosthesis: results of 150 cases. Br J Urol. 78:1996;933