Allergen avoidance in the primary prevention of asthma

Current Opinion in Allergy and Clinical Immunology

Volumn 4, Issue 1, 2004, Pages 45-51

  Simpson, Angela ^a   Custovic, Adnan ^a  

^a WYTHENSHAWE HOSPITAL   (United Kingdom)

Author keywords

Asthma; Environmental control; Primary prevention

Indexed keywords

ALLERGEN; FOOD ALLERGEN; OMEGA 3 FATTY ACID;

ASTHMA; ATOPY; BRONCHUS HYPERREACTIVITY; CLINICAL TRIAL; COUGHING; DIET SUPPLEMENTATION; DYSPNEA; ECZEMA; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MANAGEMENT; HUMAN; INHALATION; MITE; PRIMARY PREVENTION; PRIORITY JOURNAL; REVIEW; RHINITIS; TREATMENT OUTCOME; WHEEZING;

ALLERGENS; ANTIGENS, DERMATOPHAGOIDES; ASTHMA; CHILD; CHILD, PRESCHOOL; CLINICAL TRIALS; HUMANS; INCIDENCE; INFANT; INFANT, NEWBORN; INHALATION EXPOSURE; PRIMARY PREVENTION;

EID: 4143092472     PISSN: 15284050     EISSN: None     Source Type: Journal    
DOI: 10.1097/00130832-200402000-00010     Document Type: Review

References (21)

1. Simpson A, Simpson B, Custovic A, Woodcock A. Stringent environmental control in pregnancy and early life: the long term effects on mite, cat and dog allergen. Clin Exp Allergy 2003; 33:1183-1189. A study from our group showing that environmental control measures are effective in reducing mite, cat and dog allergens and are acceptable to families.
2. Ehnert B, Lau-Schadendorf S, Weber A, et al. Reducing domestic exposure to dust mite allergen reduces bronchial hyperreactivity in sensitive children with asthma. J Allergy Clin Immunol 1992; 90:135-138.
3. Woodcock A, Forster L, Matthews E, et al. Control of exposure to mite allergen by the use of allergen-impermeable bed covers for adults with asthma. N Engl J Med 2003; 349:221-232. An important recent randomized trial of mite allergen proof bedding in adults with asthma. Lung function improved in both groups, but this single intervention did not cause any great improvement in the active group compared with the control group.
4. Schonberger HJAM, van Schayck CP. Prevention of asthma in genetically predisposed children in primary care: from clinical efficacy to a feasible intervention programme. Clin Exp Allergy 1998; 28:1325-1331.
5. Arshad SH, Matthews S, Gant C, Hide DW. Effect of allergen avoidance on development of allergic disorders in infancy. Lancet 1992; 339:1493-1497.
6. Hide DW, Matthews S, Matthews L, et al. Effect of allergen avoidance in infancy on allergic manifestations at age 2 years. J Allergy Clin Immunol 1994; 93:842-846.
7. Hide DW, Matthews S, Tariq S, Arshad SH. Allergen-avoidance in infancy and allergy at 4 years of age. Allergy 1996; 51:89-93.
8. Arshad SH, Bateman B, Matthews SM. Primary prevention of asthma and atopy during childhood by allergen avoidance in infancy: a randomized controlled study. Thorax. 2003; 58:489-493. Most recent report from this important study, at age 8 years, summarized in Table 4.
9. Chan-Yeung M, Manfreda J, Dimich-Ward H, et al. A randomized controlled study on the effectiveness of a multifaceted intervention program in the primary prevention of asthma in high-risk infants. Arch Pediatr Adolesc Med. 2000; 154:657-663.
10. Chan-Yeung M, Ferguson A, Dimich-Ward H, et al. Effectiveness and compliance to intervention-measures in reducing house dust and cat allergen levels. Ann Allergy Asthma Immunol 2002; 88:52-58.
11. Halmerbauer G, Gartner C, Schierl M, et al. and the SPACE collaborative Study Team Study on the Prevention of Allergy in Children in Europe (SPACE): allergic sensitization at 1 year of age in a controlled trial of allergen avoidance from birth. Pediatr Allergy Immunol 2003; 14:10-17.
12. Mihrshahi S, Peat JK, Webb K, et al. The Childhood Asthma Prevention Study (CAPS): design and research protocol of a randomized trial for the primary prevention of asthma. Control Clin Trials 2001; 22:333-354.
13. Mihrshahi S, Marks GB, Criss S, et al. for the CAPS team. Effectiveness of an intervention to reduce house dust mite allergen levels in children's beds. Allergy 2003; 58:784-789.
14. Mihrshahi S, Peat JK, Marks. GB, et al. Eighteen-month outcomes of house dust mite avoidance and dietary fatty acid modification in the Childhood Asthma Prevention Study (CAPS). J Allergy Clin Immunol 2003; 111:162-168. First clinical results of this factorial-design intervention study.
15. Brunekreef B, Smit J, Jongste J, et al. The prevention and incidence of asthma and mite allergy (PIAMA) birth cohort study: design and first results. Pediatr Allergy Immunol 2002; 13 (Suppl 15):55-60.
16. Wijga A, Smit HA, Brunekreef B, et al. Are children at high familial risk of developing allergy born into a low risk environment? The PIAMA birth cohort study. Clin Exp Allergy 2001; 31:576-581.
17. van Strien R, Koopman L, Kerkhof M, et al. Mattress encasings and mite allergen levels in the prevention and incidence of asthma and mite allergy study. Clin Exp Allergy 2003; 33:490-495.
18. Koopman LP, van Strien R, Kerkhof M, et al. Placebo-controlled trial of house dust mite-impermeable mattress covers: effect on symptoms in early childhood. Am J Respir Crit Care Med 2002; 166:307-313.
19. Custovic A, Simpson BM, Murray CS, et al. The National Asthma Campaign Manchester Asthma and Allergy Study. Pediatr Allergy Immunol 2002; 13 (Suppl. 15):32-37.
20. Custovic A, Simpson BM, Simpson A, et al. Manchester Asthma and Allergy Study: low allergen environment can be achieved and maintained during pregnancy and in early life. J Allergy Clin Immunol 2000; 105:252-258.
21. Custovic A, Simpson BM, Simpson A, et al. Environmental control in pregnancy and early life: effect on respiratory symptoms and atopy during the first year of life. Lancet 2001; 31:1194-1204.