Amylin receptor blockade stimulates food intake in rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 287, Issue 3 56-3, 2004, Pages

  Reidelberger, Roger D ^a,b,d   Haver, Alvin C ^a   Arnelo, Urban ^c   Smith, D David ^b   Schaffert, Courtney S ^a   Permert, Johan ^c  

^a DEPARTMENT OF VETERANS AFFAIRS   (United States)

^b CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d VA Nebraska W Iowa Hlth Care Syst   (United States)

Author keywords

AC187; Islet amyloid polypeptide; Receptor antagonist; Satiety

Indexed keywords

AC 187; AMYLIN; AMYLIN RECEPTOR; RECEPTOR; RECEPTOR BLOCKING AGENT; SALCATONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANOREXIA; ARTICLE; BODY WEIGHT; BRAIN; CONTROLLED STUDY; DOSE RESPONSE; ENERGY METABOLISM; FOOD INTAKE; LIGHT DARK CYCLE; MALE; NONHUMAN; OBESITY; PANCREAS; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SATIETY; SIGNAL TRANSDUCTION; TUBE FEEDING;

AMYLOID; ANIMALS; ANOREXIA; EATING; ENTERAL NUTRITION; FOOD, FORMULATED; INJECTIONS, INTRAVENOUS; INTUBATION, GASTROINTESTINAL; PEPTIDE FRAGMENTS; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PEPTIDE;

EID: 4143092464     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00213.2004     Document Type: Article

References (40)

1. American Physiological Society. Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol 283: R281-R283, 2002.
2. Arnelo U, Permert J, Adrian TE, Larsson J, Westermark P, and Reidelberger RD. Chronic infusion of islet amyloid polypeptide causes anorexia in rats. Am J Physiol Regul Integr Comp Physiol 271: R1654-R1659, 1996.
3. Arnelo U, Permert J, Granqvist L, Adrian TE, Westermark P, Smith DD, and Reidelberger RD. Effects of AC187, IAPP(8-37) and CGRP(8-37) on IAPP-induced anorexia in rats. Soc Neurosci Abstr 23: 256, 1997.
4. Arnelo U, Reidelberger R, Adrian TE, Larsson J, and Permert J. Sufficiency of postprandial plasma levels of islet amyloid polypeptide for suppression of feeding in rats. Am J Physiol Regul Integr Comp Physiol 275: R1537-R1542, 1998.
5. Baldo BA and Kelley AE. Amylin infusion into rat nucleus accumbens potently depresses motor activity and ingestive behavior. Am J Physiol Regul Integr Comp Physiol 281: R1232-R1242, 2001.
6. Banks WA, Kastin AJ, Maness LM, Huang W, and Jaspan JB. Permeability of the blood-brain barrier to amylin. Life Sci 57: 1993-2001, 1995.
7. Bobalik GR, Kleszynski RR, Aldred JP, Bastian JW, and Schlueter RJ. Differential effects of salmon, porcine, and human calcitonin on gastric secretion and gastric emptying in rats. Proc Soc Exp Biol Med 147: 284-288, 1974.
8. Clementi G, Caruso A, Cutuli VM, de-Bernardis E, Prato A, and Amico-Roxas M. Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat. Experientia 52: 677-679, 1996.
9. Cooper GJ. Amylin compared with calcitonin gene-related peptide: structure, biology, and relevance to metabolic disease. Endocr Rey Rev 15: 163-201, 1994.
10. Dacquin R, Davey RA, Laplace C, Levasseur R, Morris HA, Goldring SR, Gebre-Medhin S, Galson DL, Zajac JD, and Karsenty G. Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J Cell Biol 164: 509-514, 2004.
11. Guidobono F, Coluzzi M, Pagani F, Pecile A, and Netti C. Amylin given by central and peripheral routes inhibits acid gastric secretion. Peptides 15: 699-702, 1994.
12. Hilton JM, Mitchelhill KI, Pozvek G, Dowton M, Quiza M, and Sexton PM. Purification of calcitonin-like peptides from rat brain and pituitary. Endocrinology 139: 982-992, 1998.
13. Kastin AJ, Akerstrom V, Hackler L, and Pan W. Adrenomedullin and the blood-brain barrier. Horm Metab Res 33: 19-25, 2001.
14. Lutz TA, Althaus J, Rossi R, and Scharrer E. Anorectic effect of amylin is not transmitted by capsaicin-sensitive nerve fibers. Am J Physiol Regul Integr Comp Physiol 274: R1777-R1782, 1998.
15. Lutz TA, Del-Prete E, and Scharrer E. Reduction of food intake in rats by intraperitoneal injection of low doses of amylin. Physiol Behav 55: 891-895, 1994.
16. Lutz TA, Del-Prete E, and Scharrer E. Subdiaphragmatic vagotomy does not influence the anorectic effect of amylin. Peptides 16: 457-462, 1995.
17. Lutz TA, Del-Prete E, Szabady MM, and Scharrer E. Attenuation of the anorectic effects of glucagon, cholecystokinin, and bombesin by the amylin receptor antagonist CGRP(8-37). Peptides 17: 119-124, 1996.
18. Lutz TA, Rossi R, Althaus J, Del-Prete E, and Scharrer E. Evidence for a physiological role of central calcitonin gene-related peptide (CGRP) receptors in the control of food intake in rats. Neurosci Lett 230: 159-162, 1997.
19. Lutz TA, Senn M, Althaus J, Del-Prete E, Ehrensperger F, and Scharrer E. Lesion of the area postrema/nucleus of the solitary tract (AP/NTS) attenuates the anorectic effects of amylin and calcitonin generelated peptide (CGRP) in rats. Peptides 19: 309-317, 1998.
20. Lutz TA, Tschudy S, Rushing PA, and Scharrer E. Amylin receptors mediate the anorectic action of salmon calcitonin (sCT). Peptides 21: 233-238, 2000.
21. Muff R, Born W, and Fischer JA. Calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin: homologous peptides, separate receptors and overlapping biological actions. Eur J Endocrinol 133: 17-20, 1995.
22. Muff R, Buhlmann N, Fischer JA, and Born W. An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or -3. Endocrinology 140: 2924-2927, 1999.
23. Mulder H, Ekelund M, Ekblad E, and Sundler F. Islet amyloid polypeptide in the gut and pancreas: localization, ontogeny and gut motility effects. Peptides 18: 771-783, 1997.
24. Mulder H, Leckstrom A, Uddman R, Ekblad E, Westermark P, and Sundler F. Islet amyloid polypeptide (amylin) is expressed in sensory neurons. J Neurosci 15: 7625-7632, 1995.
25. Nishi M, Sanke T, Nagamatsu S, Bell GI, and Steiner DF. Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits. J Biol Chem 265: 4173-4176, 1990.
26. Owyang C. Physiological mechanisms of cholecystokinin action on pancreatic secretion. Am J Physiol Gastrointest Liver Physiol 271: G1-G7, 1996.
27. Poyner D. Pharmacology of receptors for calcitonin gene-related peptide and amylin. Trends Pharmacol Sci 16: 424-428, 1995.
28. Poyner DR, Sexton PM, Marshall I, Smith DM, Quirion R, Born W, Muff R, Fischer JA, and Foord SM. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 54: 233-246, 2002.
29. Reidelberger RD, Arnelo U, Granqvist L, and Permert J. Comparative effects of amylin and cholecystokinin on food intake and gastric emptying in rats. Am J Physiol Regul Integr Comp Physiol 280: R605-R611, 2001.
30. Reidelberger RD, Kelsey L, and Heimann D. Effects of amylin-related peptides on food intake, meal patterns, and gastric emptying in rats. Am J Physiol Regul Integr Comp Physiol 282: R1395-R1404, 2002.
31. Rushing PA, Hagan MM, Seeley RJ, Lutz TA, D'Alessio DA, Air EL, and Woods SC. Inhibition of central amylin signaling increases food intake and body adiposity in rats. Endocrinology 142: 5035-5038, 2001.
32. Rushing PA, Hagan MM, Seeley RJ, Lutz TA, and Woods SC. Amylin: a novel action in the brain to reduce body weight. Endocrinology 141: 850-853, 2000.
33. Rushing PA, Seeley RJ, Air EL, Lutz TA, and Woods SC. Acute 3rd-ventricular amylin infusion potently reduces food intake but does not produce aversive consequences. Peptides 23: 985-988, 2002.
34. Skofitsch G, Wimalawansa SJ, Jacobowitz DM, and Gubisch W. Comparative immunohistochemical distribution of amylin-like and calcitonin gene related peptide like immunoreactivity in the rat central nervous system. Can J Physiol Pharmacol 73: 945-956, 1995.
35. Twery MJ, Obie JF, and Cooper CW. Ability of calcitonins to alter food and water consumption in the rat. Peptides 3: 749-755, 1982.
36. Westermark P, Wernstedt C, O'Brien TD, Hayden DW, and Johnson KH. Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone. Am J Pathol 127: 414-417, 1987.
37. Westermark P, Wernstedt C, Wilander E, and Sletten K. A novel peptide in the calcitonin gene related family as an amyloid fibril protein in the endocrine pancreas. Biochem Biophys Res Commun 140: 827-831, 1986.
38. Woltman T, Castellanos D, and Reidelberger R. Role of cholecystokinin in the anorexia produced by duodenal delivery of oleic acid in rats. Am J Physiol Regul Integr Comp Physiol 269: R1420-R1433, 1995.
39. Woltman T and Reidelberger R. Role of cholecystokinin in the anorexia produced by duodenal delivery of peptone in rats. Am J Physiol Regul Integr Comp Physiol 276: R1701-R1709, 1999.
40. Zumpe ET, Tilakaratne N, Fraser NJ, Christopoulos G, Foord SM, and Sexton PM. Multiple ramp domains are required for generation of amylin receptor phenotype from the calcitonin receptor gene product. Biochem Biophys Res Commun 267: 368-372, 2000.