Coagulopathy in the equine critical care patient

Veterinary Clinics of North America - Equine Practice

Volumn 20, Issue 1, 2004, Pages 231-251

  Dallap, Barbara L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBIN; BLOOD CLOTTING FACTOR 8; CYTOKINE; D DIMER; ENDOTOXIN; FIBRINOGEN; FLUNIXIN MEGLUMINE; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; PENTOXIFYLLINE; POLYMYXIN B; THROMBIN ANTITHROMBIN COMPLEX; TRANSACTIVATOR PROTEIN;

BLEEDING; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TEST; BLOOD FLOW; CLINICAL FEATURE; DISSEMINATED INTRAVASCULAR CLOTTING; ENDOTOXEMIA; FIBRINOLYSIS; GASTROINTESTINAL DISEASE; HEMOSTASIS; HORSE; HUMAN; INFECTION; INFLAMMATION; INJURY; INTENSIVE CARE; MORBIDITY; MORTALITY; NEOPLASM; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTHROMBIN TIME; REVIEW; RISK ASSESSMENT; STOMACH ULCER; SURVIVAL; THROMBOCYTE COUNT; THROMBOCYTE DYSFUNCTION; VETERINARY MEDICINE; VISCOELASTICITY;

ANIMALS; BLOOD COAGULATION; CRITICAL CARE; DISEASE MANAGEMENT; DISSEMINATED INTRAVASCULAR COAGULATION; FIBRINOLYSIS; HEMOSTASIS; HORSE DISEASES; HORSES; RISK FACTORS; TREATMENT OUTCOME;

EQUIDAE; EQUUS CABALLUS;

EID: 4143089503     PISSN: 07490739     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cveq.2003.11.002     Document Type: Review

References (72)

1. Marshall J. Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med. 29:(7 Suppl):2001;S99-S104
2. Taylor F. The inflammatory-coagulant axis in the host response to gram-negative sepsis: regulatory roles of proteins and inhibitors of tissue factor. New Horiz. 2:(4):1994;555-565
3. Bevilacqua M., Pober J., Majeau J., Cotran R., Gimbrone M. Jr. Interleukin 1 (IL-1) induces biosynthesis and cell expression of procoagulant activity in human vascular endothelial cells. J Exp Med. 160:(2):1984;618-623
4. Pu Q., Wiel E., Corseaux D., Bordet R., Azrin M., et al. Beneficial effect of glycoprotein IIb/IIIa inhibitor (AZ-1) on endothelium in Escherichia coli endotoxin-induced shock. Crit Care Med. 29:(6):2001;1181-1188
5. Taylor F., Wada H., Kinasewitz G. Description of compensated and uncompensated disseminated intravascular coagulation (DIC) responses (non-overt and overt DIC) in baboon models of intravenous and intraperitoneal Escherichia coli sepsis and in the human model of endotoxemia: toward a better definition of DIC. Crit Care Med. 28:(9 Suppl):2000;S12-S19
6. Tsuchiya R., Kyotani K., Scott M., Nishizono K., Ashida Y., et al. Role of platelet activating factor in development of thrombocytopenia and neutropenia in dogs with endotoxemia. Am J Vet Res. 60:(2):1999;216-221
7. Dhainaut J.F., Marin N., Mignon A., Vinsonneau C. Hepatic response to sepsis: interaction between coagulation and inflammatory processes. Crit Care Med. 29:(7 Suppl):2001;S42-S47
8. Sheu J., Hung W., Kan Y., Lee Y., Yen M. Mechanisms involved in the antiplatelet activity of Escherichia coli lipopolysaccharide in human platelets. Br J Haemotol. 103:(1):1998;29-38
9. Bates D., Parsonnet J., Ketchum P., Miller E., Novitsky T., et al. Limulus amebocyte lysate assay for detection of endotoxin in patients with sepsis syndrome. Clin Infect Dis. 27:(3):1998;582-591
10. Marshall J., Creery D. Preclinical models of sepsis. Sepsis. 2:1998;187-197
11. Wada H., Wakita Y., Nakase T., Shimura M., Hiyoyama K., et al. Outcome of disseminated intravascular coagulation in relation to the score when treatment was begun. Thromb Haemost. 74:(3):1995;848-852
12. Wada H., Sakuragawa N., Mori Y., Takagi N., Nakasaki T., et al. Hemostatic molecular markers before the onset of disseminated intravascular coagulation. Am J Hematol. 60:(4):1999;273-278
13. Rodriquez-Erdman F. Bleeding due to increased intravascular blood coagulation: hemorrhagic syndromes caused by consumption of blood-clotting factors (consumption coagulopathies). [abstract] N Engl J Med. 273:1965;1370
14. Bick R. Disseminated intravascular coagulation and related syndromes: a clinical review. Semin Thromb Hemost. 14:(4):1988;299-338
15. Bick R. Disseminated intravascular coagulation. Objective criteria for diagnosis and management. Med Clin North Am. 78:(3):1994;511-543
16. Cartlet J., Taylor F., Levi M., Artigas A., ten Cate H., et al. Clinical expert round table discussion (session 4) at the Margaux Conference on Critical Illness: sepsis: inflammation disorder, coagulation disorder, or both? A challenge for clinicians. Crit Care Med. 29:(7 Suppl):2001;S107-S108
17. Steiner P., Lushbaugh C. Maternal pulmonary embolism by amniotic fluid as a cause of shock and unexplained deaths in obstetrics. JAMA. 117:1941;1245-1250
18. Plewa M., King R., Fenn-Buderer N., Gretzinger K., Renvart D., et al. Hematologic safety of intraosseous blood transfusion in a swine model of pediatric hemorrhagic hypovolemia. Acad Emerg Med. 2:(9):1995;799-809
19. Bilgrami S., Cable R., Posciotto P., Rowland F., Greenberg B. Fatal DIC and pulmonary thrombosis following a blood transfusion in a patient with severe autoimmune hemolytic anemia and HIV infection. Transfusion. 34:(3):1994;248-352
20. Camerer E., Kolsto A., Prydz H. Cell biology of tissue factor, the principal initiator of blood coagulation. Thromb Haemost. 81:(1):1996;1-41
21. Mann K. Biochemistry and physiology of blood coagulation. Thromb Haemost. 82:(2):1999;165-174
22. Osterud B., Bjorklid E. The tissue factor pathway in disseminated intravascular coagulation. Semin Thromb Hemost. 27:(6):2001;605-615
23. Bell W. The fibrinolytic system in neoplasia. Semin Thromb Hemost. 22:(6):1996;459-478
24. Prentice C. Acquired coagulation disorders. Clin Haematol. 14:(2):1985;413-421
25. Chiaretti A., Piastra M., Pulitanos S., Pietrini D., DeRosa G., et al. Prognostic factors and outcome of children with severe head injury: an eight year experience. Childs Nerv Syst. 18:(3-4):2002;129-136
26. Gando S. DIC in trauma patients. Semin Thromb Hemost. 322:(4):2001;222-228
27. Slappendel R. Disseminated intravascular coagulation. Vet Clin North Am Small Anim Pract. 18:(1):1988;169-184
28. Morris D. Recognition and management of disseminated intravascular coagulation in horses. Vet Clin North Am Equine Pract. 4:(1):1988;115-143
29. Wright I. The nomenclature of blood clotting factors. Thromb Diath Haemost. 7:1962;381-388
30. Ratnoff O., Colpy J. A familial hemorrhagic trait associated with a deficiency of a clot-promoting fraction of plasma. J Clin Invest. 34:1955;602-613
31. Duckert F., Jung D., Schmerling D. A hitherto undescribed congenital haemorrhagic diathesis probably due to fibrin stabilizing factor deficiency. Throm Diath Haemorrh. 5:1961;179-181
32. Osterud B., Rapaport S. Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation. Proc Natl Acad Sci USA. 74:(12):1977;5260-5264
33. Ruf W., Mueller B. Tissue factor signaling. Thromb Haemost. 82:(2):1999;175-182
34. Gando S., Kameue T., Morimoto Y., Matsunda N., Hayakawa M., et al. Tissue factor production not balanced by tissue factor pathway inhibition in sepsis promotes poor prognosis. Crit Care Med. 30:(8):2002;1729-1734
35. Levi M., de Jonge E., van der Pol T., ten Cate H. Advances in the understanding of the pathogenetic pathways of disseminated intravascular coagulation result in more insight in the clinical picture and better management strategies. Semin Thromb Hemost. 27:(6):2001;569-575
36. Osterud B., Bjorklid E. The tissue factor pathway in disseminated coagulation. Semin Thromb Hemost. 27:(6):2001;605-616
37. Taylor F. Response of anticoagulant pathways in disseminated intravascular coagulation. Semin Thromb Hemost. 27:(6):2001;619-632
38. de Jonge E., Dekkers P., Creasey A., Hack C., Paulson S., et al. Tissue factor pathway inhibitor dose dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia. Blood. 95:(4):2000;1124-1129
39. van der Poll T., de Jonge E., Levi M. Regulatory role of cytokines in disseminated intravascular coagulation. Semin Thromb Hemost. 27:(6):2001;639-651
40. Wharram B., Fitting K., Kunkel S., Remick D., Merritt S., et al. Tissue factor expression in endothelial cell/monocyte cocultures stimulated by lipopolysaccharide and/or aggregated IgG. Mechanisms of cell:cell communication. J Immunol. 146:(5):1991;1437-1445
41. van der Poll T., Levi M., van Deventer S., ten Cate H., Haagmans B., et al. Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees. Blood. 83:(2):1994;446-451
42. Bernard W., Morris D., Divers T., Ramberg C. Plasma antithrombin III values in clinically normal horses: effect of sex and/or breed. Am J Vet Res. 48:(5):1987;866-868
43. Green R. Clinical implications of antithrombin III deficiency in animal diseases. Compend Contin Educ Pract Vet. 6:(6):1984;537-545
44. Bernard G., Wesley E., Wright T., Fraiz J., Stasek J., et al. Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis. Crit Care Med. 29:(11):2001;2051-2057
45. van der Poll T., Coyle S., Levi M., Jansen P., Denterer M., et al. Effect of a recombinant dimeric tumor necrosis factor receptor on inflammatory responses to intravenous endotoxin in normal humans. Blood. 89:(10):1997;3727- 3734
46. Morris D., Beech J. Disseminated intravascular coagulation in six horses. J Am Vet Med Assoc. 10:(2):1983;1067-1072
47. Collatos C., Barton M., Prasse K., Moore J. Intravascular and peritoneal coagulation and fibrinolysis in horses with acute gastrointestinal tract diseases. J Am Vet Med Assoc. 207:(4):1995;465-470
48. Pablo L., Purohit R., Teer P., Newton J., Hammond L. Disseminated intravascular strangulation obstruction in ponies. Am J Vet Res. 44:(1):1983;2115-2122
49. Welch R., Watkins J., Taylor T., Cohen N., Carter G. Disseminated intravascular coagulation associated with colic in 23 horses (1984-1989). J Vet Intern Med. 6:(1):1992;29-35
50. Johnstone I., Crane S. Haemostatic abnormalities in horses with colic - their prognostic value. Equine Vet J. 18:(4):1986;271-274
51. Prasse K., Topper M., Moore J., Welles E. Analysis of hemostasis in horses with colic. J Am Vet Med Assoc. 5:(1):1993;685-693
52. Collatos C., Barton M., Moore J. Fibrinolytic activity in plasma from horses with gastrointestinal diseases: changes associated with diagnosis, surgery and outcome. J Vet Intern Med. 9:(1):1995;18-23
53. Dolente B., Wilkins P., Boston R. Clinicopathologic evidence of disseminated intravascular coagulation in horses with acute colitis. J Am Vet Med Assoc. 220:(7):2002;1034-1038
54. Dallap B, Dolente B, Boston R. Coagulation profiles in 27 horses with large colon volvulus. In: Proceedings of the 11th Annual Veterinary Meeting of the American College of Veterinary Surgeons. Chicago; 2001. p. 4.
55. Barton M., Morris D., Norton N., Prasse K. Hemostatic and fibrinolytic indices in neonatal foals with presumed septicemia. J Vet Intern Med. 12:(1):1998;26-35
56. Barton M., Morris D., Crowe N., Collatos C., Prasse K. Hemostatic indices in healthy foals from birth to one month of age. J Vet Diagn Invest. 7:1995;380-385
57. Chuansumrit A., Hotrakitya S., Hathirat P., Isarangkura P. Disseminated intravascular coagulation in children: diagnosis, management and outcome. Southeast Asian J Trop Med. 24:(1):1993;229-233
58. Colmon R.W. Hemostasis and thrombosis: basic principles and clinical practices. 1982;JB Lippincott, Philadelphia. p. 693-700
59. Mammen E. Antithrombin: its physiological importance and role in DIC. Semin Thromb Hemost. 24:(1):1998;19-25
60. Pecon J., Blackburn M. Pyridoxylation of essential lysines in the heparin-binding site of antithrombin III. J Biol Chem. 259:(2):1984;935-938
61. Yamauchi T., Umeda F., Inoguchi T., Nawata H. Antithrombin III stimulates prostacyclin production by cultured aortic endothelial cells. Biochem Biophys Res Commun. 163:(3):1989;1404-1411
62. Asakura H., Ontachi Y., Mizutni T., Kato M., Ito T., et al. Decreased plasma activity of antithrombin or protein C is not due to consumption coagulopathy in septic patients with disseminated intravascular coagulation. Eur J Haemtol. 67:(3):2001;170-175
63. Holland M., Kelly A., Snyder J., Steffey E., Willits N., et al. Antithrombin III activity in horses with large colon torsion. Am J Vet Res. 47:(4):1986;897-900
64. Topper M., Prasse K., Morris M., Duncan A., Crow N. Enzyme-linked immunosorbent assay for thrombin-antithrombin III complexes in horses. Am J Vet Res. 57:(4):1996;427-431
65. Topper M., Prasse K. Use of enzyme-linked immunosorbent assay to measure thrombin-antithrombin III complexes in horses with colic. Am J Vet Res. 57:(4):1996;456-462
66. Sandholm M., Vidovic A., Puotunen-Reinert A., Sankari S., Nyholm K., et al. D-dimer improves the prognostic value of combined clinical and laboratory data in equine gastrointestinal colic. Acta Vet Scand. 36:(2):1995;255-272
67. Stokol T., Brooks M., Erb H., Mauldin G. D-dimer concentrations in healthy dogs and dogs with disseminated intravascular coagulation. Am J Vet Res. 61:(4):2000;393-398
68. Pizzo S. Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes. Am J Med. 87:(3 Suppl):1989;B10S-B14S
69. Garcia-Fernandez N., Montes R., Purroy A., et al. Hemostatic disturbances in patients with systemic inflammatory response syndrome (SIRS) and associated acute renal failure (ARF). Thromb Res. 100:2000;19-25
70. Otto C., Reiser T., Brooks M., Russell M. Evidence of hypercoagulability in dogs with parvoviral enteritis. J Am Vet Med Assoc. 217:(10):2000;1500-1504
71. Durando M., MacKay R., Linda S., Skelley L. Effects of polymixin B and Salmonella typhimurium antiserum on horses given endotoxin intravenously. Am J Vet Res. 55:(7):1994;921-927
72. Schwarzwald C., Fiege K., Wunderli-Allenspach H., Braun B. Comparison of pharmacokinetic variables for two low molecular weight heparins after subcutaneous administration of a single dose to horses. Am J Vet Res. 63:(6):2002;868-873