Derangements in cardiac metabolism in the ischemic state and consequences of reperfusion

Advanced Studies in Medicine

Volumn 4, Issue 6 B, 2004, Pages

  Gerstenblith, Gary ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; FATTY ACID; OXYGEN RADICAL;

ACIDOSIS; CELL DEATH; CYTOSOL; ENERGY CONSUMPTION; ENERGY EXPENDITURE; ENERGY RESOURCE; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLYCOLYSIS; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART MUSCLE REPERFUSION; HUMAN; HYPOTHESIS; LACTATE BLOOD LEVEL; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXYGENATION; POLYMORPHONUCLEAR CELL; REVIEW;

EID: 4143063494     PISSN: 15303004     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (37)

1. Weiss RG, Chacko VP, Gerstenblith G. Fatty acid regulation of glucose metabolism in the intact beating rat heart assessed by carbon-13 NMR spectroscopy: the critical role of pyruvate dehydrogenase. J Mol Cell Cardiol. 1989;21(5):469-478.
2. Balaban RS. Cardiac energy metabolism homeostasis: role of cytosolic J Mol Cell Cardiol. 2002;34(10):1259-1271.
3. Levitsky S, Feinberg H. Biochemical changes of ischemia. Ann Thorac Surg. 1975;20(1):21-29.
4. Stanley WC. Cardiac energetics during ischaemia and the rationale for metabolic interventions. Coron Artery Dis. 2001;12(suppl 1):S3-S7.
5. Das DK, Engelman RM, Rousou JA, Breyer RH. Aerobic vs anaerobic metabolism during ischemia in heart muscle. Ann Chir Gynaecol. 1987;76(1):68-76.
6. Zhao ZQ, Vinten-Johansen J. Myocardial apoptosis and ischemic preconditioning. Cardiovasc Res. 2002;55(3):438-455.
7. Opie LH. The mechanism of myocyte death in ischaemia. Eur Heart J. 1993;14(suppl G):31-33.
8. Chakraborti S, Chakraborti T, Mandal M, Mandal A, Das S, Ghosh S. Protective role of magnesium in cardiovascular diseases: a review. Mol Cell Biochem. 2002;238(1-2):163-179.
9. Bagchi D, Wetscher GJ, Bagchi M, et al. Interrelationship between cellular calcium homeostasis and free radical generation in myocardial reperfusion injury. Chem Biol Interact. 1997;104(2-3):65-85.
10. Di Lisa F. Mitochondrial contribution in the progression of cardiac ischemic injury. IUBMB Life. 2001;52(3-5):255-261.
11. Monteiro P, Oliveira PJ, Goncolves L, Providencia LA. Mitochondria: role in ischemia, reperfusion and cell death. Rev Port Cardiol. 2003;22(2):233-254.
12. Opie LH, Sack MN. Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning. J Mol Cell Cardiol. 2002;34(9): 1077-1089.
13. Pacher P, Csordas G, Hajnoczky G. Mitochondrial ca(2+) signaling and cardiac apoptosis. Biol Signals Recept. 2001;10(3-4):200-223.
14. Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J, Hoppel CL. Mitochondrial dysfunction in cardiac disease: ischemia-reperfusion, aging, and heart failure. J Mol Cell Cardiol. 2001;33(6):1065-1089.
15. Dispersyn GD, Borgers M, Flameng W. Apoptosis in chronic hibernating myocardium: sleeping to death? Cardiavasc Res. 2000;45(3):696-703.
16. Ferrari R, Ferrari F, Benigno M, Pepi P, Visioli O. Hibernating myocardium: its pathophysiology and clinical role. Mol Cell Biochem. 1998;186(1-2):195-199.
17. Schulz R, Heusch G. Myocardial hibernation-adaptation to ischemia. Z Kardiol. 2000;89(suppl 9):101-108.
18. Lüss H, Schafers M, Neumann J, et al. Biochemical mechanisms of hibernation and stunning in the human heart. Cardiovasc Res. 2002;56(3):411-421.
19. Flitter WD. Free radicals and myocardial reperfusion injury. Br Med Bull. 1993;49(3):545-555.
20. Piper HM, Meuter K, Schafer C. Cellular mechanisms of ischemia-reperfusion injury. Ann Thorac Surg. 2003;75(2): S644-S648.
21. Ambrosio G, Tritto I. Reperfusion injury: experimental evidence and clinical implications. Am Heart J. 1999;138(2, pt 2):S69-S75.
22. Park JL, Lucchesi BR. Mechanisms of myocardial reperfusion injury. Ann Thorac Surg. 1999;68(5):1905-1912.
23. Zhang JG, Ghosh S, Ockleford CD, Galinanes M. Characterization of an in vitro model for the study of the short and prolonged effects of myocardial ischaemia and reperfusion in man. Clin Sci (Lond). 2000;99(5):443-453.
24. Levraut J, Iwase H, Shao AZ, Vanden Hoek TL, Schumacker PT. Cell death during ischemia: relationship to mitochondrial depolarization and ROS generation. Am J Physiol Heart Circ Physiol. 2003;284(2):H549-H558.
25. Xie GH, Rah SY, Yi KS, et al. Increase of intracellular Ca(2+) during ischemia/reperfusion injury of heart is mediated by cyclic ADP-ribose. Biochem Biophys Res Commun. 2003;307(3):713-718.
26. Wang QD, Pernow J, Sjoquist PO, Ryden L. Pharmacological possibilities for protection against myocardial reperfusion injury. Cardiovasc Res. 2002;55(1):25-37.
27. Jones SP, Hoffmeyer MR, Sharp BR, Ho YS, Lefer DJ. Role of intracellular antioxidant enzymes after in vivo myocardial ischemia and reperfusion. Am J Physiol Heart Circ Physiol. 2003;284(1):H277-H282.
28. Kaminski KA, Bonda TA, Korecki J, Musial WJ. Oxidative stress and neutrophil activation-the two keystones of ischemia/reperfusion injury. Int J Cardiol. 2002;86(1):41-59.
29. Toufektsian MC, Boucher FR, Tanguy S, Morel S, de Leiris JG. Cardiac toxicity of singlet oxygen: implication in reperfusion injury. Antioxid Redox Signal. 2001;3(1):63-69.
30. Baxter GF. The neutrophil as a mediator of myocardial ischemia-reperfusion injury: time to move on. Basic Res Cardiol. 2002;97(4):268-275.
31. Holleyman CR, Larson DF. Apoptosis in the ischemic reperfused myocardium. Perfusion. 2001;16(6):491-502.
32. Tritto I, Ambrosio G. Role of oxidants in the signaling pathway of preconditioning. Antioxid Redox Signal. 2001;3(1):3-10. Erratum in: Antioxid Redox Signal. 2001;3(5):937.
33. Tritto I, Ambrosio G. Role of oxidants in the signaling pathway of preconditioning. Antioxid Redox Signal. 2001;3(1):3-10. Erratum in: Antioxid Redox Signal. 2001;3(5):937.
34. Soares PR, de Albuquerque CP, Chacko VP, Gerstenblith G, Weiss RG. Role of preischemic glycogen depletion in the improvement of postischemic metabolic and contractile recovery of ischemia-preconditioned rat hearts. Circulation. 1997;96(3):975-983.
35. Weiss RG, de Albuquerque CP, Vandegaer K, Chacko VP, Gerstenblith G. Attenuated glycogenolysis reduces glycolytic catabolite accumulation during ischemia in preconditioned rat hearts. Circ Res. 1996;79(3):435-446.
36. Weiss RG, Kalil-Filho R, Herskowitz A, et al. Tricarboxylic acid cycle activity in postischemic rat hearts. Circulation. 1993;87(1):270-282.
37. Baumgarten KM, Gerstenblith G, Weiss RG. High extracellular K+ during hypoxic preconditioning episodes attenuates the post-ischemic contractile and ionic benefits of preconditioning. J Mol Cell Cardiol. 1999;31(1):203-213.