Locally delivered doxycycline improves the healing following non-surgical periodontal therapy in smokers

Journal of Clinical Periodontology

Volumn 31, Issue 8, 2004, Pages 589-595

  Tomasi, Cristiano ^a   Wennström, Jan L ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Debridement; Doxycycline; Local drug delivery; Multicenter; Periodontitis; Randomised controlled trial; Scaling and root planing

Indexed keywords

ATRIDOX; DOXYCYCLINE;

ADULT; ARTICLE; BLEEDING; CALCULATION; CLINICAL EXAMINATION; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; FEMALE; GEL; HUMAN; INSTRUMENTATION; MAJOR CLINICAL STUDY; MALE; MOUTH HYGIENE; MULTICENTER STUDY; PERIODONTAL DISEASE; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SMOKING; STATISTICAL ANALYSIS; SURGICAL TECHNIQUE; TREATMENT OUTCOME; ULTRASOUND; VIRUS CULTURE; WOUND HEALING;

ADMINISTRATION, TOPICAL; ANTI-BACTERIAL AGENTS; DENTAL SCALING; DOXYCYCLINE; FEMALE; HUMANS; MALE; MIDDLE AGED; PERIODONTAL POCKET; REGRESSION ANALYSIS; ROOT PLANING; SINGLE-BLIND METHOD; SMOKING; TREATMENT OUTCOME;

EID: 4143051132     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2004.00524.x     Document Type: Article

References (33)

1. Ah, M. K., Johnson, G. K., Kaldahl, W. B., Patil, K. D. & Kalkwarf, K. L. (1994) The effect of smoking on the response to periodontal therapy. Journal of Clinical Periodontology 21, 91-97.
2. Ashley, R. A. (1999) Clinical trials of a matrix metalloproteinase inhibitor in human periodontal disease. SDD Clinical Research Team. Annals of the New York Academy of Sciences 878, 335-346.
3. Bezerra, M. M., Brito, G. A., Ribeiro, R. A. & Rocha, F. A. (2002) Low-dose doxycycline prevents inflammatory bone resorption in rats. Brazilian Journal of Medical and Biological Research 35, 613-616.
4. Biddle, A. J., Palmer, R. M., Wilson, R. F. & Watts, T. L. (2001) Comparison of the validity of periodontal probing measurements in smokers and non-smokers. Journal of Clinical Periodontology 28, 806-812.
5. Boström, L., Bergström, J., Dahlen, G. & Linder, L. E. (2001) Smoking and subgingival microflora in periodontal disease. Journal of Clinical Periodontology 28, 212-219.
6. Cobb, C. M. (1996) Non-surgical pocket therapy: mechanical. Annals of Periodontology 1, 443-490.
7. Darby, I. B., Hodge, P. J., Riggio, M. P. & Kinane, D. F. (2000) Microbial comparison of smoker and non-smoker adult and early-onset periodontitis patients by polymerase chain reaction. Journal of Clinical Periodontology 27, 417-424.
8. Golub, L. M., Lee, H. M., Greenwald, R. A., Ryan, M. E., Sorsa, T., Salo, T. & Giannobile, W. V. (1997) A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflammation Research 46, 310-319.
9. Golub, L. M., McNamara, T. F., Ryan, M. E., Kohut, B., Blieden, T., Payonk, G., Sipos, T. & Baron, H. J. (2001) Adjunctive treatment with subantimicrobial doses of doxycycline: effects on gingival fluid collagenase activity and attachment loss in adult periodontitis. Journal of Clinical Periodontology 28, 146-156.
10. Golub, L. M., Sorsa, T., Lee, H. M., Ciancio, S., Sorbi, D., Ramamurthy, N. S., Gruber, B., Salo, T. & Konttinen, Y. T. (1995) Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. Journal of Clinical Periodontology 22, 100-109.
11. Grenier, D., Plamondon, P., Sorsa, T., Lee, H. M., McNamara, T., Ramamurthy, N. S., Golub, L. M., Teronen, O. & Mayrand, D. (2002) Inhibition of proteolytic, serpinolytic, and progelatinase-b activation activities of periodontopathogens by doxycycline and the non-antimicrobial chemically modified tetracycline derivatives. Journal of Periodontology 73, 79-85.
12. Grossi, S. G., Zambon, J., Machtei, E. E., Schifferle, R., Andreana, S., Genco, R. J., Cummins, D. & Harrap, G. (1997) Effects of smoking and smoking cessation on healing after mechanical periodontal therapy. Journal of the American Dental Association 128, 599-607.
13. Gustafsson, A., Åsman, B. & Bergström, K. (1994) Altered relation between granulocyte elastase and alpha-2-macroglobulin in gingival crevicular fluid from sites with periodontal destruction. Journal of Clinical Periodontology 21, 17-21.
14. Haffajee, A. D. & Socransky, S. S. (2001) Relationship of cigarette smoking to the subgingival microbiota. Journal of Clinical Periodontology 28, 377-388.
15. Hung, H. C. & Douglass, C. W. (2002) Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss. Journal of Clinical Periodontology 29, 975-986.
16. Kinane, D. F. & Radvar, M. (1997) The effect of smoking on mechanical and antimicrobial periodontal therapy. Journal of Periodontology 68, 467-472.
17. Korostoff, J. M., Wang, J. F., Sarment, D. P., Stewart, J. C., Feldman, R. S. & Billings, P. C. (2000) Analysis of in situ protease activity in chronic adult periodontitis patients: expression of activated MMP-2 and a 40 kDa serine protease. Journal of Periodontology 71, 353-360.
18. Llavaneras, A., Golub, L. M., Rifkin, B. R., Heikkila, P., Sorsa, T., Teronen, O., Salo, T., Liu, Y., Ryan, M. E. & Ramamurthy, N. S. (1999) CMT-8/clodronate combination therapy synergistically inhibits alveolar bone loss in LPS-induced periodontitis. Annals of the New York Academy of Sciences 878, 671-674.
19. Novak, M. J., Johns, L. P., Miller, R. C. & Bradshaw, M. H. (2002) Adjunctive benefits of subantimicrobial dose doxycycline in the management of severe, generalized, chronic periodontitis. Journal of Periodontology 73, 762-769.
20. Palmer, R. M., Matthews, J. P. & Wilson, R. F. (1999) Non-surgical periodontal treatment with and without adjunctive metronidazole in smokers and non-smokers. Journal of Clinical Periodontology 26, 158-163.
21. Persson, L., Bergström, J., Ito, H. & Gustafsson, A. (2001) Tobacco smoking and neutrophil activity in patients with periodontal disease. Journal of Periodontology 72, 90-95.
22. Polson, A. M. (1997) The research team, calibration, and quality assurance in clinical trials in periodontics. Annals of Periodontology 2, 75-82.
23. Preber, H. & Bergström, J. (1986) The effect of non-surgical treatment on periodontal pockets in smokers and non-smokers. Journal of Clinical Periodontology 13, 319-323.
24. Ramamurthy, N. S., Rifkin, B. R., Greenwald, R. A., Xu, J. W., Liu, Y., Turner, G., Golub, L. M. & Vernillo, A. T. (2002) Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines. Journal of Periodontology 73, 726-734.
25. Ryder, M. I., Pons, B., Adams, D., Beiswanger, B., Blanco, V., Bogle, G., Donly, K., Hallmon, W., Hancock, E. B., Hanes, P., Hawley, C., Johnson, L., Wang, H. L., Wolinsky, L., Yukna, R., Polson, A., Carron, G. & Garrett, S. (1999) Effects of smoking on local delivery of controlled-release doxycycline as compared to scaling and root planing. Journal of Clinical Periodontology 26, 683-691.
26. Scabbia, A., Cho, K. S., Sigurdsson, T. J., Kim, C. K. & Trombelli, L. (2001) Cigarette smoking negatively affects healing response following flap debridement surgery. Journal of Periodontology 72, 43-49.
27. Stoller, N. H., Johnson, L. R., Trapnell, S., Harrold, C. Q. & Garrett, S. (1998) The pharmacokinetic profile of a biodegradable controlled-release delivery system containing doxycycline compared to systemically delivered doxycycline in gingival crevicular fluid, saliva, and serum. Journal of Periodontology 69, 1085-1091.
28. Stoltze, K. (1992) Concentration of metronidazole in periodontal pockets after application of a metronidazole 25% dental gel. Journal of Clinical Periodontology 19, 698-701.
29. Van der Weijden, G. A. & Timmerman, M. F. (2002) A systematic review on the clinical efficacy of subgingival debridement in the treatment of chronic periodontitis. Journal of Clinical Periodontology 29, 55-71.
30. van Winkelhoff, A. J., Bosch-Tijhof, C. J., Winkel, E. G. & van der Reijden, W. A. (2001) Smoking affects the subgingival microflora in periodontitis. Journal of Periodontology 72, 666-671.
31. Wennström, J. L., Newman, H. N., MacNeill, S. R., Killoy, W. J., Griffiths, G. S., Gillam, D. G., Krok, L., Needleman, I. G., Weiss, G. & Garrett, S. (2001) Utilisation of locally delivered doxycycline in non-surgical treatment of chronic periodontitis. A comparative multi-centre trial of 2 treatment approaches. Journal of Clinical Periodontology 28, 753-761.
32. Williams, R. C., Paquette, D. W., Offenbacher, S., Adams, D. F., Armitage, G. C., Bray, K., Caton, J., Cochran, D. L., Drisko, C. H., Fiorellini, J. P., Giannobile, W. V., Grossi, S., Guerrero, D. M., Johnson, G. K., Lamster, I. B., Magnusson, I., Oringer, R. J., Persson, G. R., Van Dyke, T. E., Wolff, L. F., Santucci, E. A., Rodda, B. E. & Lessem, J. (2001) Treatment of periodontitis by local administration of minocycline microspheres: a controlled trial. Journal of Periodontology 72, 1535-1544.
33. Zambon, J. J., Grossi, S. G., Machtei, E. E., Ho, A. W., Dunford, R. & Genco, R. J. (1996) Cigarette smoking increases the risk for subgingival infection with periodontal pathogens. Journal of Periodontology 67, 1050-1054.