Response: 5-Azacytidine induction of human fetal hemoglobin

Blood

Volumn 111, Issue 4, 2008, Pages 2486-

  Mabaera, Rodwell ^b   Lowrey, Christopher H ^a  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; DNA; GAMMA GLOBIN; HEMOGLOBIN F; MESSENGER RNA; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

DNA METHYLATION; DNMT1 GENE; DOSE RESPONSE; DRUG MECHANISM; GENE; GENE EXPRESSION; GENE INDUCTION; HEMOGLOBINOPATHY; HUMAN; LETTER; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

EID: 41349102759     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-11-125070     Document Type: Letter

References (3)

1. Mabaera R, Greene MR, Richardson CA, Conine SJ, Kozul CD, Lowrey CH. Neither DNA hypomethylation nor changes in the kinetics of erythroid differentiation explain 5-azacytidine's ability to induce human fetal hemoglobin. Blood. 2008;111:411-420.
2. Dover GJ, Charache SH, Boyer SH, Talbot CC, Jr., Smith KD. 5-Azacytidine increases fetal hemoglobin production in a patient with sickle cell disease. Prog Clin Biol Res. 1983;134:475-488.
3. Fathallah H, Weinberg RS, Galperin Y, Sutton M, Atweh GF. Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin. Blood. 2007;110:3391-3397.