The presence of high-risk chromosome aberrations in chronic lymphocytic leukaemia does not correlate with centrosome aberrations

Hematological Oncology

Volumn 26, Issue 1, 2008, Pages 39-42

  Ottaggio, Laura ^a   Zunino, Annalisa ^a   Maric, Irena ^b   Grozio, Alessia ^b   Rossi, Edoardo ^a   Spriano, Mauro ^a   Viaggi, Silvia ^a,b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

B CLL; Centrosomes; Chromosome aberrations; Prognostic markers

Indexed keywords

ADULT; AGED; ARTICLE; B CELL LEUKEMIA; CENTROSOME; CHROMOSOME ABERRATION; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE CONTROL; GENE LOCUS; HEMATOLOGIC MALIGNANCY; HIGH RISK PATIENT; HUMAN; IMMUNOFLUORESCENCE TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; REGULATORY MECHANISM; RELIABILITY; SOLID TUMOR;

ADULT; AGED; AGED, 80 AND OVER; CENTROSOME; CHROMOSOME ABERRATIONS; FEMALE; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; RISK;

EID: 41349096277     PISSN: 02780232     EISSN: 10991069     Source Type: Journal    
DOI: 10.1002/hon.838     Document Type: Article

References (16)

1. Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910-1916.
2. Hinchcliffe EH, Sluder G. Two for two: Cdk2 and its role in centrosome doubling. Oncogene 2002; 21: 6154-6160.
3. Kawamura K, Morita N, Domiki C, et al. Induction of centrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure. Cancer Sci 2006; 97: 252-258.
4. Shen K, Wang Y, Brooks SC, Raz A, Wang YA. ATM is activated by mitotic stress and suppresses centrosome amplification in primary but not in tumor cells. J Cell Biochem 2006; 99: 1267-1274.
5. Fukasawa K. Centrosome amplification, chromosome instability and cancer development. Cancer Lett 2005; 230: 6-19.
6. Kraemer A, Neben K, Ho AD. Centrosome aberrations in haematological malignancies. Cell Biol Int 2005; 29: 375-383.
7. Hensel M, Zoz M, Giesecke C, et al. High rate of centrosome aberrations and correlation with proliferative activity in patients with untreated B-cell chronic lymphocytic leukaemia. Int J Cancer 2007; 121: 978-983.
8. Chiorazzi N, Ferrarini M. Evolving view of the in-vivo kinetics of chronic lymphocytic leukemia B cells. Hematology Am Soc Hematol Educ Program 2006; 512: 273-278.
9. Pihan GA, Purohit A, Wallace J, et al. Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression. Cancer Res 2001; 61: 2212-2219.
10. Karhu R, Knuutila S, Kallioniemi OP, et al. Frequent loss of the 11q14-24 region in chronic lymphocytic leukemia: a study by comparative genomic hybridization. Tampere CLL Group. Genes Chromosomes Cancer 1997; 19: 286-290.
11. Bentz M, Huck K, du Manoir S, et al. Comparative genomic hybridization in chronic B-cell leukemias shows a high incidence of chromosomal gains and losses. Blood 1995; 85: 3610-3618.
12. du Manoir S, Schroeck E, Bentz M, et al. Quantitative analysis of comparative genomic hybridization. Cytometry 1995; 19: 27-41.
13. Oricchio E, Saladino C, Iacovelli S, Soddu S, Cundari E. ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity. Cell Cycle 2006; 5: 88-92.
14. Kraemer A, Schweizer S, Neben K, et al. Centrosome aberrations as a possible mechanism for chromosomal instability in non-Hodgkin's lymphoma. Leukemia 2003; 17: 2207-2213.
15. Ottaggio L, Viaggi S, Zunino A, et al. Chromosome aberrations evaluated by comparative genomic hybridization in B-cell chronic lymphocytic leukemia: correlation with CD38 expression. Haematologica 2003; 7: 769-777.
16. Lin K, Sherrington PD, Dennis M, et al. Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia. Blood 2002; 100: 1404-1409.