Towards predictive inhibitor design for the EGFR autophosphorylation activity

European Journal of Medicinal Chemistry

Volumn 43, Issue 4, 2008, Pages 781-791

  San Juan, Amor A ^a,b  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

3D QSAR; Autophosphorylation; EGFR; Ligand design; Lung cancer

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; PROTEIN TYROSINE KINASE; PYRROLE DERIVATIVE; QUINAZOLINE DERIVATIVE;

ARTICLE; AUTOPHOSPHORYLATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG DESIGN; HUMAN; HUMAN CELL; HYDROGEN BOND; MOLECULAR DOCKING; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; QUANTITATIVE ANALYSIS; REACTION OPTIMIZATION; STATISTICAL MODEL; STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING; VALIDATION PROCESS;

BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PHOSPHORYLATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 41249085277     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.06.006     Document Type: Article

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