Adverse effects of methylene blue on the central nervous system

Anesthesiology

Volumn 108, Issue 4, 2008, Pages 684-692

  Vutskits, Laszlo ^a,b   Briner, Adrian ^a   Klauser, Paul ^c   Gascon, Eduardo ^d   Dayer, Alexandre G ^a,b   Kiss, Jozsef Z ^b   Muller, Dominique ^b   Licker, Marc J ^c   Morel, Denis R ^c  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^c UNIVERSITY OF GENEVA   (Switzerland)

^d AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; ISOFLURANE; METHYLENE BLUE; PROPIDIUM IODIDE;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL DIFFERENTIATION; CONTROLLED STUDY; DENDRITIC CELL; DOSE RESPONSE; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; EXCITATORY POSTSYNAPTIC POTENTIAL; HEMODYNAMICS; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MINIMUM LUNG ALVEOLUS CONCENTRATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STAINING; TAIL FLICK TEST;

EID: 41149175103     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e3181684be4     Document Type: Article

References (47)

1. Camp NE: Methemoglobinemia. J Emerg Nurs 2007; 33:172-4
2. Patel PN: Methylene blue for management of ifosfamide-induced encephalopathy. Ann Pharmacother 2006; 40:299-303
3. Evora PR, Viaro F: The guanylyl cyclase inhibition by MB as vasoplegic circulatory shock therapeutical target. Curr Drug Targets 2006; 7:1195-204
4. Kwok ES, Howes D: Use of methylene blue in sepsis: A systematic review. J Intensive Care Med 2006; 21:359-63
5. Bruno MJ: Magnification endoscopy, high resolution endoscopy, and chromoscopy: Towards a better optical diagnosis. Gut 2003; 52 (suppl 4):iv7-11
6. Kiesslich R, Neurath MF, Galle PR: Chromoendoscopy and magnifying endoscopy in patients with gastroesophageal reflux disease: Useful or negligible? Dig Dis 2004; 22:142-7
7. Marana R, Catalano GF, Muzii L: Salpingoscopy. Curr Opin Obstet Gynecol 2003; 15:333-6
8. Dudley NE: Methylene blue for rapid identification of the parathyroids. BMJ 1971; 3:680-1
9. Derom AF, Wallaert PC, Janzing HM, Derom FE: Intraoperative identification of parathyroid glands with methylene blue infusion. Am J Surg 1993; 165:380-2
10. Kuriloff DB, Sanborn KV: Rapid intraoperative localization of parathyroid glands utilizing methylene blue infusion. Otolaryngol Head Neck Surg 2004; 131:616-22
11. Robert J, Delay D, Buhler L, Garcia A, Spilipoulos A: Methylene blue in surgery of primary hyperparathyroidism [in French]. Ann Endocrinol (Paris) 1998; 59:23-6
12. Peter C, Hongwan D, Kupfer A, Lauterburg BH: Pharmacokinetics and organ distribution of intravenous and oral methylene blue. Eur J Clin Pharmacol 2000; 56:247-50
13. Bach KK, Lindsay FW, Berg LS, Howard RS: Prolonged postoperative disorientation after methylene blue infusion during parathyroidectomy. Anesth Analg 2004; 99:1573-4
14. Kartha SS, Chacko CE, Bumpous JM, Fleming M, Lentsch EJ, Flynn MB: Toxic metabolic encephalopathy after parathyroidectomy with methylene blue localization. Otolaryngol Head Neck Surg 2006; 135:765-8
15. Khan MA, North AP, Chadwick DR: Prolonged postoperative altered mental status after methylene blue infusion during parathyroidectomy: A case report and review of the literature. Ann R Coll Surg Engl 2007; 89:W9-11
16. Majithia A, Stearns MP: Methylene blue toxicity following infusion to localize parathyroid adenoma. J Laryngol Otol 2006; 120:138-40
17. Martindale SJ, Stedeford JC: Neurological sequelae following methylene blue injection for parathyroidectomy. Anaesthesia 2003; 58:1041-2
18. Mathew S, Linhartova L, Raghuraman G: Hyperpyrexia and prolonged postoperative disorientation following methylene blue infusion during parathyroidectomy. Anaesthesia 2006; 61:580-3
19. Mihai R, Mitchell EW, Warwick J: Dose-response and postoperative confusion following methylene blue infusion during parathyroidectomy. Can J Anaesth 2007; 54:79-81
20. Siebert C, Kroeber S, Lutter N: Prolonged postoperative disorientation after methylene blue infusion during parathyroidectomy. Anesth Analg 2005; 101:608-9
21. Sweet G, Standiford SB: Methylene-blue-associated encephalopathy. J Am Coll Surg 2007; 204:454-8
22. Nadler E, Green H, Rosenbaum A: Intravenous injection of methylene blue in man with reference to its toxic symptoms and effect on the electrocardiogram. Am J Med Sci 1934; 188:15-21
23. Garthwaite G, Garthwaite J: Cyclic GMP and cell death in rat cerebellar slices. Neuroscience 1988; 26:321-6
24. Poppers PJ, Mastri AR, Lebeaux M, Covino BG: The effect of methylene blue on neural tissue. ANESTHESIOLOGY 1970; 33:335-40
25. Eger EI, Saidman LJ, Brandstater B: Minimum alveolar anesthetic concentration: A standard of anesthetic potency. ANESTHESIOLOGY 1965; 26:756-63
26. Stoppini L, Buchs PA, Muller D: A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 1991; 37:173-82
27. Gascon E, Vutskits L, Zhang H, Barral-Moran MJ, Kiss PJ, Mas C, Kiss JZ: Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro. Eur J Neurosci 2005; 21:69-80
28. Schmued LC, Hopkins KJ: Fluoro-Jade B: A high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 2000; 874:123-30
29. Vutskits L, Gascon E, Kiss JZ: Removal of PSA from NCAM affects the survival of magnocellular vasopressin- and oxytocin-producing neurons in organotypic cultures of the paraventricular nucleus. Eur J Neurosci 2003; 17:2119-26
30. Masaki E, Kondo I: Methylene blue, a soluble guanylyl cyclase inhibitor, reduces the sevoflurane minimum alveolar anesthetic concentration and decreases the brain cyclic guanosine monophosphate content in rats. Anesth Analg 1999; 89:484-9
31. Vutskits L, Gascon E, Potter G, Tassonyi E, Kiss JZ: Low concentrations of ketamine initiate dendritic atrophy of differentiated GABAergic neurons in culture. Toxicology 2007; 234:216-26
32. Cechova S, Pajewski TN: The soluble guanylyl cyclase inhibitor ODQ, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, dose-dependently reduces the threshold for isoflurane anesthesia in rats. Anesth Analg 2004; 99:752
33. Johns RA, Moscicki JC, DiFazio CA: Nitric oxide synthase inhibitor dose-dependently and reversibly reduces the threshold for halothane anesthesia: A role for nitric oxide in mediating consciousness? ANESTHESIOLOGY 1992; 77:779-84
34. G-L-arginine methyl ester, dose dependently reduce the threshold for isoflurane anesthesia. ANESTHESIOLOGY 1996; 85:1111-9
35. Tobin JR, Martin LD, Breslow MJ, Traystman RJ: Selective anesthetic inhibition of brain nitric oxide synthase. ANESTHESIOLOGY 1994; 81:1264-9
36. Mayer B, Brunner F, Schmidt K: Inhibition of nitric oxide synthesis by methylene blue. Biochem Pharmacol 1993; 45:367-74
37. Wolin MS, Cherry PD, Rodenburg JM, Messina EJ, Kaley G: Methylene blue inhibits vasodilation of skeletal muscle arterioles to acetylcholine and nitric oxide via the extracellular generation of superoxide anion. J Pharmacol Exp Ther 1990; 254:872-6
38. Stockand JD, Sansom SC: Activation by methylene blue of large Ca(2+)-activated K+ channels. Biochim Biophys Acta 1996; 1285:123-6
39. Soares-da-Silva P, Caramona MM: Effects of methylene blue on the uptake, release and metabolism of noradrenaline in mesenteric arterial vessels. J Pharm Pharmacol 1988; 40:534-8
40. Lee YS, Wurster RD: Methylene blue induces cytotoxicity in human brain tumor cells. Cancer Lett 1995; 88:141-5
41. Spielmann H, Liebsch M: Lessons learned from validation of in vitro toxicity test: From failure to acceptance into regulatory practice. Toxicol In Vitro 2001; 15:585-90
42. Robinson TE, Kolb B: Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology 2004; 47 (suppl 1):33-46
43. van Ooyen A, Duijnhouwer J, Remme MW, van Pelt J: The effect of dendritic topology on firing patterns in model neurons. Network 2002; 13:311-25
44. Berde C, Cairns B: Developmental pharmacology across species: Promise and problems. Anesth Analg 2000; 91:1-5
45. Lorthioir J: Syndrome de la queue de cheval après injection de bleu de methylene dans le cul-de-sac arachnoidien lombo-sacré. Acta Chir Belg 1957; 56:312-7
46. Evans JP, Keegan HR: Danger in the use of intrathecal methylene blue. JAMA 1960; 174:856-9
47. Pyzik S, Hines I: Quadriplegia after intrathecal injection of methylene blue. JAMA 173:130-2