Liver histology in ICU patients dying from sepsis: A clinico-pathological study

World Journal of Gastroenterology

Volumn 14, Issue 9, 2008, Pages 1389-1393

  Koskinas, John ^a   Gomatos, Ilias P ^a   Tiniakos, Dina G ^a   Memos, Nikolaos ^a   Boutsikou, Maria ^a   Garatzioti, Aspasia ^a   Archimandritis, Athanasios ^a   Betrosian, Alexander ^b  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b HIPPOKRATION HOSPITAL   (Greece)

Author keywords

Biopsy; Histology; Liver; Severe sepsis

Indexed keywords

ADULT; AGED; APOPTOSIS; ARTICLE; CHOLANGITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DYING; FATTY LIVER; FEMALE; HEPATITIS; HISTOPATHOLOGY; HOSPITALIZATION; HUMAN; HUMAN TISSUE; INTENSIVE CARE UNIT; LIVER BIOPSY; LIVER FAILURE; LIVER FUNCTION TEST; LIVER INJURY; LIVER NECROSIS; LIVER PARENCHYMA; MALE; SEPSIS;

EID: 41149174772     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.14.1389     Document Type: Article

References (23)

1. Jacobi J. Pathophysiology of sepsis. Am J Health Syst Pharm 2002; 59 Suppl 1: S3-S8
2. Vermillion SE, Gregg JA, Baggenstoss AH, Bartholomew LG. Jaundice associated with bacteremia. Arch Intern Med 1969; 124: 611-618
3. Pastor CM, Billiar TR, Losser MR, Payen DM. Liver injury during sepsis. J Crit Care 1995; 10: 183-197
4. Banks JG, Foulis AK, Ledingham IM, Macsween RN. Liver function in septic shock. J Clin Pathol 1982; 35: 1249-1252
5. Bone RC, Fisher CJ Jr, Clemmer TP, Slotman GJ, Metz CA, Balk RA. Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group. Crit Care Med 1989; 17: 389-393
6. Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, Ramsay G, Zimmerman JL, Vincent JL, Levy MM. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32: 858-873
7. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp-Arida A, Yeh M, McCullough AJ, Sanyal AJ. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-1321
8. Sikuler E, Guetta V, Keynan A, Neumann L, Schlaeffer F. Abnormalities in bilirubin and liver enzyme levels in adult patients with bacteremia. A prospective study. Arch Intern Med 1989; 149: 2246-2248
9. Zimmerman HJ, Fang M, Utili R, Seeff LB, Hoofnagle J. Jaundice due to bacterial infection. Gastroenterology 1979; 77: 362-374
10. Vermillion SE, Gregg JA, Baggenstoss AH, Bartholomew LG. Jaundice associated with bacteremia. Arch Intern Med 1969; 124: 611-618
11. Lefkowitch JH. Bile ductular cholestasis: an ominous histopathologic sign related to sepsis and "cholangitis lenta". Hum Pathol 1982; 13: 19-24
12. Lysova NL, Gurevich LE, Trusov OA, Shchegolev AI, Mishnev OD. Immunohistochemical characteristics of the liver in patients with peritonitis (early autopsy). Bull Exp Biol Med 2001; 132: 1125-1129
13. Vyberg M, Poulsen H. Abnormal bile duct epithelium accompanying septicaemia. Virchows Arch A Pathol Anat Histopathol 1984; 402: 451-458
14. Scheuer PJ, Lefkowitch JH. Liver biopsy interpretation. 7th ed. Philadelphia: Elsevier Saunders, 2006: 331-332
15. Hirata K, Ikeda S, Honma T, Mitaka T, Furuhata T, Katsuramaki T, Hata F, Mukaiya M. Sepsis and cholestasis: basic findings in the sinusoid and bile canaliculus. J Hepatobiliary Pancreat Surg 2001; 8: 20-26
16. Crawford JM, Boyer JL. Clinicopathology conferences: inflammation-induced cholestasis. Hepatology 1998; 28: 253-260
17. Lefkowitch JH. Histological assessment of cholestasis. Clin Liver Dis 2004; 8: 27-40
18. Moseley RH. Sepsis-associated cholestasis. Gastroenterology 1997; 112: 302-306
19. Burt AD. Liver pathology associated with diseases of other organs or systems. In: Portmann BC, Ferrell LD, MacSween RNM. MacSween's Pathology of the Liver. 5th ed. London: Churchill Livingstone, 2007:881-932
20. Ludwig J, Batts KP. Practical liver biopsy interpretation: diagnostic algorithms. 2nd ed. Chicago: ASCP Press, 1998: 53-54
21. Cone LA, Woodard DR, Schlievert PM, Tomory GS. Clinical and bacteriologic observations of a toxic shock-like syndrome due to Streptococcus pyogenes. N Engl J Med 1987; 317: 146-149
22. Ceydeli A, Condon MR, Siegel JH. The septic abscess wall: a cytokine-generating organ associated with portal venous cytokinemia, hepatic outflow fibrosis, sinusoidal congestion, inflammatory cell sequestration, hepatocellular lipid deposition, and focal cell death. Shock 2003; 20: 74-84
23. James PE, Madhani M, Roebuck W, Jackson SK, Swartz HM. Endotoxin-induced liver hypoxia: defective oxygen delivery versus oxygen consumption. Nitric Oxide 2002; 6: 18-28