Paradoxical behavior of neuromedin U in isolated smooth muscle cells and intact tissue

Journal of Pharmacology and Experimental Therapeutics

Volumn 325, Issue 1, 2008, Pages 154-164

  Brighton, Paul J ^a   Wise, Alan ^b   Dass, Narinder B ^b   Willars, Gary B ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; NEUROMEDIN U;

ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CELL STRAIN HEK293; COLON MUCOSA; DESENSITIZATION; DRUG BINDING SITE; ENDOTHELIUM CELL; EX VIVO STUDY; HUMAN; HUMAN CELL; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; STIMULATION; UMBILICAL VEIN;

ANIMALS; CALCIUM SIGNALING; COLON; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; MEMBRANE PROTEINS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; NEUROPEPTIDES; PROTEIN BINDING; RATS; RECEPTORS, NEUROTRANSMITTER;

EID: 41149167193     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.132803     Document Type: Article

References (40)

1. 1 receptor is a single-copy gene-characterisation in a stable cell-line. Mol Cell Biochem 131:75-86.
2. i/o activation in CHO-cells expressing human muscarinic acetylcholine receptors: dependence on agonist as well as receptor-subtype. Brit J Pharmacol 132:950-958.
3. Benito-Orfila MA, Domin J, Nandha KA, and Bloom SR (1991) The motor effect of neuromedin-U on rat stomach in vitro. Eur J Pharmacol 193:329-333.
4. Brighton PJ, Szekeres PG, and Willars GB (2004a) Neuromedin U and its receptors; structure function and physiological roles. Pharmacol Rev 56:231-248.
5. i and an irreversible ligand-receptor interaction. Mol Pharmacol 66:1544-1556.
6. Cao CQ, Yu XH, Dray A, Filosa A, and Perkins MN (2003) A pro-nociceptive role of neuromedin U in adult mice. Pain 104:609-616.
7. Chu CP, Jin QH, Kunitake T, Kato K, Nabekura T, Nakazato M, Kanagawa K, and Kannan H (2002) Cardiovascular actions of central neuromedin U in conscious rats. Regul Peptides 105:29-34.
8. Dart C and Standen NB (1993) Adenosine-activated potassium current in smooth-muscle cells isolated from the pig coronary-artery. J Physiol 471:767-786.
9. Dass NB, John AK, Bassil AK, Crumbley CW, Shehee WR, Maurio FP, Moore GBT, Taylor CM, and Sanger GJ (2007) The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation. Neurogastroent Motil 19:66-74.
10. Dass NB, Munonyara M, Bassil AK, Hervieu GJ, Osbourne S, Corcoran S, Morgan M, and Sanger GJ (2003) Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin. Neurosci 120:443-453.
11. Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Habata Y, Hinuma S, Onda H, Nishimura O, and Fujino M (2000) Identification of neuromedin U as the cognate ligand of the orphan G-protein-coupled receptor FM-3. J Biol Chem 275:21068-21074.
12. Gardiner SM, Compton AM, Bennett T, Domin J, and Bloom SR (1990) Regional hemodynamic-effects of neuromedin-U in conscious rats. Am J Physiol Regul Integr Comp Physiol 258:R32-R38.
13. Hanada R, Nakazato M, Murakami N, Sakihara S, Yoshimatsu H, Toshinai K, Hanada T, Suda T, Kangawa K, Matsukura S, et al. (2001) A role for neuromedin U in stress response. Biochem Biophys Res Commun 289:225-228.
14. Hedrick JA, Morse K, Shan LX, Qiao XD, Pang L, Wang S, Laz T, Gustafson EL, Bayne M, and Monsma FJ (2000) Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U. Mol Pharmacol 58:870-875.
15. Hosoya M, Moriya T, Kawamata Y, Ohkubo S, Fujii R, Matsui H, Shintani Y, Fukusumi S, Habata Y, Hinuma S, et al. (2000) Identification and functional characterization of a novel subtype of neuromedin U receptor. J Biol Chem 275:29528-29532.
16. Howard AD, Wang RP, Pong SS, Mellin TN, Strack A, Guan XM, Zeng ZZ, Williams DL, Feighner SD, Nunes CN, et al. (2000) Identification of receptors for neuromedin U and its role in feeding. Nature 406:70-74.
17. Ivanov TR, Lawrence CB, Stanley PJ, and Luckman SM (2002) Evaluation of neuromedin U actions in energy homeostasis and pituitary function. Endocrinology 143:3813-3821.
18. Jethwa PH, Small CJ, Smith KL, Seth A, Darch SJ, Abbott CR, Murphy KG, Todd JF, Ghatei MA, and Bloom SR (2005) Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin. Am J Physiol Endocrinol Metab 289:E301-E305.
19. Jones NA, Morton MF, Prendergast CE, Powell GL, Shankley NP, and Hollingsworth SJ (2006) Neuromedin U stimulates contraction of human long saphenous vein and gastrointestinal smooth muscle in vitro. Regul Pept 136:109-116.
20. Kojima M, Haruno R, Nakazato M, Date Y, Murakami N, Hanada R, Matsuo H, and Kangawa K (2000) Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3). Biochem Biophys Res Commun 276:435-438.
21. Ma X, Wang Y, and Stephens NL (1998) Serum deprivation induces a unique hypercontractile phenotype of cultured smooth muscle cells. Am J Physiol Cell Physiol 274:C1206-C1214.
22. Maggi CA, Patacchini R, Giuliani S, Turini D, Barbanti G, Rovero P, and Meli A (1990) Motor response of the human isolated small-intestine and urinary-bladder to porcine neuromedin U-8. Brit J Pharmacol 99:186-188.
23. Malendowicz KA, Nussdorfer GG, Nowak KW, and Mazzocchi G (1993) Effects of neuromedin U-8 on the rat pituitary-adrenocortical axis. In Vivo 7:419-422.
24. Minamino N, Kangawa K, and Matsuo H (1985) Neuromedin-U-8 and neuromedin-U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal-cord. Biochem Biophys Res Commun 130:1078-1085.
25. Nakahara K, Hanada R, Murakami N, Teranishi H, Ohgusu H, Fukushima N, Moriyama M, Ida T, Kangawa K, and Kojima M (2004) The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Biochem Biophys Res Commun 318:156-161.
26. Nakazato M, Hanada R, Murakami N, Date Y, Mondal MS, Kojima M, Yoshimatsu H, Kangawa K, and Matsukura S (2000) Central effects of neuromedin U in the regulation of energy homeostasis. Biochem Biophys Res Commun 277:191-194.
27. Nandha KA, Benito-Orfila MA, Smith DM, and Bloom SR (1993) Characterization of the rat uterine neuromedin-U receptor. Endocrinology 133:482-486.
28. Prendergast CE, Morton MF, Figueroa KW, Wu XD, and Shankley NP (2006) Species-dependent smooth muscle contraction to neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice. Brit J Pharmacol 147:886-896.
29. Raddatz R, Wilson AE, Artymyshyn R, Bonini JA, Borowsky B, Boteju LW, Zhou SQ, Kouranova EV, Nagorny R, Guevarra MS, et al. (2000) Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. J Biol Chem 275:32452-32459.
30. Sakura N, Kurosawa K, and Hashimoto T (1995) Structure-activity- relationships of neuromedin-U: I. Contractile activity of dog neuromedin-U-related peptides on isolated chicken crop smooth-muscle. Chem Pharm Bull 43:1148-1153.
31. Savineau JP and Marthan R (2000) Cytosolic calcium oscillations in smooth muscle cells. News Physiol Sci 15:50-55.
32. Shan LX, Qiao XD, Crona JH, Behan J, Wang S, Laz T, Bayne M, Gustafson EL, Monsma FJ, and Hedrick JA (2000) Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. J Biol Chem 275:39482-39486.
33. Skalli O, Gabbiani G, Babai F, Seemayer TA, Pizzolato G, and Schurch W (1988) Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin: II. Rhabdomyosarcomas. Am J Pathol 130:515-531.
34. i-proteins and intracellular calcium sensitivity of vasoconstriction in the intact rat tail artery. Brit J Pharmacol 131:1337-1344.
35. Szekeres PG, Muir AI, Spinage LD, Miller JE, Butler SI, Smith A, Rennie GI, Murdock PR, Fitzgerald LR, Wu HL, et al. (2000) Neuromedin U is a potent agonist at the orphan G-protein-coupled receptor FM3. J Biol Chem275:20247-20250.
36. Westfall TD, McCafferty GP, Pullen M, Gruver S, Sulpizio AC, Aiyar VN, Disa J, Contino LC, Mannan IJ, and Hieble JP (2001) Characterisation of neuromedin U effects in canine smooth muscle. J Pharmacol Exp Ther 301:987-992.
37. Wren AM, Small CJ, Abbott CR, Jethwa PH, Kennedy AR, Murphy KG, Stanley SA, Zollner AN, Ghatei MA, and Bloom SR (2002) Hypothalamic actions of neuromedin U. Endocrinology 143:4227-4234.
38. Yamashita K, Upadhyay S, Osada M, Hoque MO, Xiao Y, Mori M, Sato F, Meltzer SJ, and Sidransky D (2002) Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma. Cancer Cell 2:485-495.
39. Yu XH, Cao CQ, Mennicken F, Puma C, Dray A, O'Donnell D, Ahmad S, and Perkins M (2003) Pro-nociceptive effects of neuromedin U in rat. Neuroscience 120:467-474.
40. Zeng HK, Gragerov A, Hohmann JG, Gragerov A, Hohmann JG, Pavlova MN, Schimpf BA, Xu H, Wu LJ, Toyoda H, et al. (2006) Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding. Mol Cell Biol 26:9352-9363.