The pathophysiology of osteoporotic hip fracture

McGill Journal of Medicine

Volumn 11, Issue 1, 2008, Pages 51-57

  Metcalfe, David ^a,b  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; GLUCOCORTICOID; VITAMIN D;

AGING; ALCOHOL CONSUMPTION; ANOREXIA NERVOSA; BONE DENSITY; DUAL ENERGY X RAY ABSORPTIOMETRY; EXERCISE; FALLING; FRAGILITY FRACTURE; HEALTH PROMOTION; HIP FRACTURE; HUMAN; NUTRITIONAL DEFICIENCY; OSTEOPOROSIS; PATHOPHYSIOLOGY; REVIEW; RISK FACTOR; SALT INTAKE; SMOKING; VITAMIN SUPPLEMENTATION;

EID: 41149164290     PISSN: 1201026X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (71)

1. Rodan GA. Good hope for making osteoporosis a disease of the past. Osteoporos Int. 4:S5-S6; 1994
2. World Health Organization. Assessment of fracture risk and its application to screening for post-menopausal osteoporosis. Report of a WHO Study Group 2004.
3. Shipley M, Black CM, Denton CP, Compston J, O'Gradaigh D. Rheumatology and bone disease. In: Kumar P, Clark M, editors. Clinical Medicine. Philadelphia: Elsevier Saunders, 2005.
4. Chartered Society of Physiotherapy. Effectiveness of falls prevention and rehabilitation strategies in older people: implications for physiotherapy. London: CSP 2001.
5. Cauley JA. Osteoporosis in men: prevalence and investigation. Clin Cornerstone. 8:S20-S25; 2006.
6. Lippuner K, Golder M, Greiner R. Epidemiology and direct medical costs of osteoporotic fractures in men and women in Switzerland. Osteoporos Int. 16:S8-S17; 2005.
7. Riggs BL, Melton LJ. The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone 17:505S-511S; 1995.
8. Keen, R. W. Burden of osteoporosis and fractures. Curr Osteoporos Res. 1:66-70; 2003.
9. Lippuner K, von Overbeck J, Perrelet R, Bosshard H, Jaeger P. Incidence and direct medical costs of hospitalizations due to osteoporotic fractures in Switzerland. Osteoporos Int. 7:414-425; 1997.
10. Goldacre MJ, Roberts SE, Yeates D. Mortality after admission to hospital with fractured neck of femur: database study. BMJ 325:868-869; 2002.
11. Snell RS. Clinical Anatomy. 7th ed. New York: Lippincott Williams & Wilkins, 2003:636-644.
12. Moore KL, Dalley AF. Clinically Orientated Anatomy. 5th ed. New York: Lippincott Williams & Wilkins, 2006.
13. Reece VAC. Fractured neck of femur: a guide for immediate-care nurses in the Accident & Emergency department. South Tyneside Health care NHS Trust 2002.
14. Jessberger S, Blattert TR, Wagner R, Weckbach A. Reducing approach-associated morbidity in fracture dislocation of the femoral head - a longitudinal study (1982-2000). Zentralbl Chir 127:485-489; 2002.
15. Golzman D. Discoveries, drugs and skeletal disorders. Nature 1:784-796; 2002.
16. Hordon LD, Peacock M. Osteomalacia and osteoporosis in femoral neck fracture. Bone Miner. 11:247-259; 1990.
17. Dempster DW. Osteoporosis in men. In: Favus MJ, ed. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Washington DC: The American Society for Bone and Mineral Research, 2006.
18. Guyton AC, Hall JE eds. Medical Physiology, 10th edition. WB Saunders Company: Philadelphia, 2000.
19. World Health Organisation. Prevention and Management of Osteoporosis. WHO Technical Report Series 2003.
20. Kanis JA, Johnell O, Gullberg B et al. Risk factors for hip fracture in men from Southern Europe: the MEDOS study. Osteoporos Int. 9:45-54; 1999.
21. Felson TF, Douglas PK, Jennifer JA, Kannel WB. Alcohol consumption and hip fractures: the Framingham study. Am J Epidemiol. 128:1102-1110; 1998.
22. Turner RT, Sibonga JD. Effects of alcohol use and estrogen on bone. National Institute on Alcohol Abuse and Alcoholism 2002.
23. Laitinen K, Valimaki M. Alcohol and bone. Calcif Tissue Int. 49:S70-S73; 1991.
24. Wong PK, Christie JJ, Wark JD. The effects of smoking on bone health. Clin Sci (Lond) 113:233-241; 2007.
25. Cohen AJ, Roe FJ. Review of risk factors for osteoporosis with particular reference to a possible aetiological role of dietary salt. Food Chem Toxicol. 38:237-253; 2000.
26. Massey LK. Effect of dietary salt intake on circadian calcium metabolism, bone turnover, and calcium oxalate kidney stone risk in postmenopausal women. Nutrition Research 25:891-903; 2005.
27. Nordin BEC, Need AG, Steurer T, Morris HA, Chatterton BA, Horowitz M. Nutrition, osteoporosis and aging. Ann N Y Acad Sci. 854:336-351; 1998.
28. Hannan MT, Tucker KL, Dawson-Hughes B, Cupples LA, Felson DT, Kiel DP. Effect of dietary protein on bone loss in elderly men and women: the Framingham osteoporosis study. J Bone Min Res. 15:2504-2512; 2000.
29. Amin S, LaValley MP, Simms RW, Felson DT. The role of vitamin D in corticosteroid-induced osteoporosis: a meta-analytic approach. Arthritis Rheum 42:1740-1751; 1999.
30. Gloth FM, Smith CE, Hollis BW, Tobin JD. Functional improvement with vitamin D replenishment in a cohort of frail, vitamin D-deficient older people. J Am Geriatr Soc. 43:1269-1271; 1995.
31. Diamond TH, Levy S, Smith A, Day P. High bone turnover in Muslim women with vitamin D deficiency. Med J Aust. 177:139-141; 2002.
32. Feskanich D, Weber P, Willett WC, Rockett H, Booth SL, Colditz GA. Vitamin K intake and hip fractures in women: a prospective study. Am J Clin Nutr 69:74-79; 1999.
33. Dominguez J, Goodman L, Gupta S, Mayer L, Etu SF, Walsh BT, Wang J, Pierson R, Warren MP. Treatment of anorexia nervosa is associated with increases in bone mineral density, and recovery is a biphasic process involving both nutrition and return of menses. Am J Clin Nutr 86:92-99; 2007.
34. Gnudi S, Sitta E, Fiuimi N. Relationship between body composition and bone mineral density in women with and without osteoporosis: relative contribution of lean and fat mass. J Bone Miner Metab. 25:329-332; 2007.
35. van Staa TP, Leufkens HGM, Abenhaim L, Begaud B, Zhang B. Use of oral corticosteroids in the United Kingdom. Q J Med. 93:105-111; 2000.
36. Canalis E, Mazziotti G, Giustina A, Bilezikian JP. Glucocorticoid-induced osteoporosis: pathophysiology and therapy. Osteoporos Int. In Press.
37. de Vries F, Bracke M, Leufkens HG, Lammers JW, Cooper C, van Staa TP. Fracture risk with intermittent high-dose oral glucocorticoid therapy. Arthritis Rheum. 56:208-214; 2007.
38. Lane NE. An update on glucocorticoid-induced osteoporosis. Curr Opin Rheumatol. 27:235-253; 2001.
39. Huybers S, Naber Th, Bindeis RJ, Hoenderop JG. Prednisolone-induced Ca2+ malabsorption is caused by diminished expression of the epithelial Ca2+ channel TRPV6. Am J Physiol Gastrointest Liver Physiol 292:92-97; 2007.
40. Compston JE. Emerging consensus on prevention and treatment of glucocorticoid-induced osteoporosis. Curr Rheumatol Rep. 9:78-84; 2007.
41. National Osteoporosis Foundation. Physician's guide to prevention and treatment of osteoporosis. Washington DC: National Osteoporosis Foundation, 2003.
42. Orwoll ES. Osteoporosis in men. In: Favus MJ, ed. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Washington DC: The American Society for Bone and Mineral Research, 2006.
43. Pacifici R. Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis. J Bone Miner Res. 11:1043-1051; 1996.
44. Dunne F, Walters B, Marshall T, Heath DA. Pregnancy associated osteoporosis. Clin Endocrinol (Oxf) 39:487-490; 1993.
45. Karlsson C, Obrant KJ, Karlsson M. Pregnacy and lactation confer reversible bone loss in humans. Osteoporos Int. 12:828-834; 2001.
46. Thomas E, Cox C, Murphy D, Beddard K. Hip fracture during labour due to transient osteoporosis of the hip in pregnancy. J Obstet Gynaecol. 20:197-198; 2000.
47. Kastelan D, Kralijevic I, Kujundzic-Tiljak M, et al. Osteoporosis prevalence in Croatian males - the results of calcaneus ultrasound. Lijec Vjesn 129:123-129; 2007.
48. Cooper C, Campion G, Melton LJ. Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 2:285-289; 1992.
49. Amin S, Felson DT. Osteoporosis in men. Rheum Dis Clin North Am 27:19-47; 2001.
50. Campion JM, Maricic MJ. Osteoporosis in men. Am Fam Physician 67:1521-1526; 2003.
51. Araujo AB, Esche GR, Kupelian V, et al. Prevalence of symptomatic androgen deficiency in men. J Clin Endocrinol Metab. In Press.
52. Riggs BL, Wahner HW, Melton LJ, et al. Rate of bone loss in the axial and appendicular skeleton of women: evidence of substantial bone loss prior to menopause. J Clin Invest 77:1847-1891; 1986.
53. Seeman E. Pathogenesis of bone fragility in women and men. Lancet 359:1841-1850; 2002.
54. Gillespie LD, Gillespie WJ, Cumming R, Lamb SE, Rowe BH. Interventions for preventing falls in the elderly. In: Cochrane Library. Issue 1. Oxford: Update Software, 2003.
55. Chartered Society of Physiotherapy. Effectiveness of falls prevention and rehabilitation strategies in older people: implications for physiotherapy. London: CSP, 2001.
56. Department of Health. National service framework for older people. London: DoH, 2001.
57. American Geriatrics Society, British Geriatrics Society and American Academy of Orthopedic Surgeons. Panel on Falls Prevention. Guidelines for the prevention of falls in older persons. J Am Geriatr Soc. 2001 49:664-672.
58. Ernst E. Exercise for female osteoporosis: a systematic review of randomised clinical trials. Sports Medicine 1998 25:359-368.
59. Scottish Intercollegiate Guidelines Network. Management of osteoporosis: a national clinical guideline. Edinburgh: Royal College of Physicians, 2003:15-29.
60. Morris FL, Naughton GA, Gibbs JL, Carlson JS, Wark JD. Prospective ten-month exercise intervention in premenarcheal girls: positive effects on bone and lean mass. J Bone Miner Res. 1997 12:1453-1462.
61. Weinsier RL, Krumdieck CL. Dairy foods and bone health: examination of the evidence. Am J Clin Nutr. 2000 72:681-689.
62. Cumming RG, Nevitt MC. Calcium for prevention of osteoporotic fractures in postmenopausal women. J Bone Miner Res. 1997 12:1321-1329.
63. Napoli N, Thompson J, Civitelli R, Armamento-Villareal RC. Effects of dietary calcium compared with calcium supplements on estrogen metabolism and bone mineral density. Am J Clin Nutr. 2007 85:1428-1433.
64. Straub DA. Calcium supplementation in clinical practice: a review of forms, doses, and indications. Nutr Clin Pract. 2007 22:286-296.
65. Gennari C. Calcium and vitamin D nutrition and bone disease of the elderly. Public Health Nutr. 2001 4:547-559.
66. Gillespie LD, Gillespie WJ, Cumming R, Lamb SE, Rowe BH. Interventions for preventing falls in the elderly. In: Cochrane Library. Issue 1. Oxford: Update Software, 2003.
67. Chang JT, Morton SC, Rubenstein LZ, et al. Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials. BMJ 2004 328:680-684.
68. Cowling PD. Hip protectors and their role in hip fracture prevention: a review. McGill Journal of Medicine 2004 8:58-65.
69. Parker M. Diagnosis and immediate care of fractured neck of femur. Hosp Med. 2001 63:42-43.
70. Birks YF, Porthouse J, Addie C, et al. Randomized controlled trial of hip protectors among women living in the community. Osteoporos Int. 2004 15:701-706.
71. van Schoor NM, de Bruyne MC, van der Roer N, et al. Cost-effectiveness of hip protectors in frail institutionalzed elderly. Osteoporos Int. 2004 15:964-969.