Discovery of 2-amino-6-carboxamidobenzothiazoles as potent Lck inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 7, 2008, Pages 2324-2328

  Huang, Shenlin ^a   Liu, Zuosheng ^a   Tian, Shin Shay ^a   Sandberg, Mark ^a   Spalding, Tracy A ^a   Romeo, Russell ^a   Iskandar, Maya ^a   Wang, Zhiliang ^a   Karanewsky, Donald ^a   He, Yun ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

2 Amino 6 carboxamidobenzothiazole; Lck inhibitor

Indexed keywords

2 AMINO 6 CARBOXAMIDOBENZOTHIAZOLE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE LCK INHIBITOR; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; B-LYMPHOCYTES; BENZAMIDES; BENZOTHIAZOLES; BINDING SITES; CELL LINE; CELL PROLIFERATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; MODELS, CHEMICAL; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41149161326     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.02.079     Document Type: Article

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