Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 7, 2006, Pages 1947-1949

  Aoyagi, Yutaka ^a   Hitotsuyanagi, Yukio ^a   Hasuda, Tomoyo ^a   Fukaya, Haruhiko ^a   Takeya, Koichi ^a   Aiyama, Ritsuo ^b   Matsuzaki, Takeshi ^b   Hashimoto, Shusuke ^b  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

Author keywords

Antitumor; C ring; Semisynthesis; Structure activity relationships; Triptolide analogues

Indexed keywords

ANTILEUKEMIC AGENT; TRIPTOLIDE;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; DITERPENES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; PHENANTHRENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33144485264     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.12.098     Document Type: Article

References (9)

1. S.M. Kupchan, W.A. Court, R.G. Dailey Jr., C.J. Gilmore, and R.F. Bryan J. Am. Chem. Soc. 94 1972 7194
2. J.P. Kutney, G.M. Hewitt, T. Kurihara, P.J. Salisbury, R.D. Sindelar, K.L. Stuart, P.M. Townsley, W.T. Chalmers, and G.G. Jacoli Can. J. Chem. 59 1981 2677
3. H. Duan, Y. Takaishi, H. Momota, Y. Ohmoto, T. Taki, M. Tori, S. Takaoka, Y. Jia, and D. Li Tetrahedron 57 2001 8413
4. R.S. Buckanin, S.J. Chen, D.M. Frieze, F.T. Sher, and G.A. Berchtold J. Am. Chem. Soc. 102 1980 1200
5. D. Yang, X.-Y. Ye, and M. Xu J. Org. Chem. 65 2000 2208
6. Crystallographic data for compounds 5 and 7 have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication No. CCDC287799 and No. CCDC287800, respectively. Copies of the data can be obtained, free of charge, on application to the Director, CCDC (e-mail: deposit@ccdc.cam.ac.uk ).
7. D.Q. Yu, D.M. Zhang, H.B. Wang, and X.T. Liang Chin. Chem. Lett. 2 1991 937
8. D.Q. Yu, D.M. Zhang, H.B. Wang, and X.T. Liang Yaoxue Xuebao 27 1992 830
9. S.M. Kupchan, and R.M. Schubert Science 185 1974 791