Gastric leptin, but not estrogen and somatostatin, contributes to the elevation of ghrelin mRNA expression level in fasted rats

Journal of Endocrinology

Volumn 196, Issue 3, 2008, Pages 529-538

  Zhao, Zheng ^a   Sakata, Ichiro ^a   Okubo, Yusuke ^a   Koike, Kanako ^a   Kangawa, Kenji ^b   Sakai, Takafumi ^a  

^a SAITAMA UNIVERSITY   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; ESTRADIOL; ESTROGEN; GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; SOMATOSTATIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FOOD INTAKE; HORMONE RELEASE; HORMONE SYNTHESIS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INHIBITION KINETICS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REFEEDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; AROMATASE; EATING; ESTROGENS; FASTING; GASTRIC MUCOSA; GENE EXPRESSION; GHRELIN; LEPTIN; MALE; RATS; RATS, WISTAR; RECEPTORS, LEPTIN; RNA, MESSENGER; SOMATOSTATIN; TISSUE CULTURE TECHNIQUES;

EID: 41149154846     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-07-0300     Document Type: Article

References (39)

1. Ariyasu H, Takaya K, Hosoda H, Iwakura H, Ebihara K, Mori K, Ogawa Y, Hosoda K, Akamizu T, Kojima I et al. 2002 Delayed short term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin. Endocrinology 143 3341-3350.
2. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA et al. 2001 Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120 337-345.
3. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, GuerreMillo M, LeMarchandBrustel Y et al. 1998 The stomach is a source of leptin. Nature 394 790-793.
4. Bagnasco M, Kalra PS & Kalra SP 2002 Ghrelin and leptin pulse discharge in fed and fasted rats. Endocrinology 143 726-729.
5. Barkan AL, Dimaraki EV, Jessup SK, Symons KV, Ermolenko M & Jaffe CA 2003 Ghrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels. Journal of Clinical Endocrinology and Metabolism 88 2180-2184.
6. Beck B, Richy S & Stricker-Krongrad A 2003 Ghrelin and body weight regulation in the obese Zucker rat in relation to feeding state and dark/ light cycle. Experimental Biology and Medicine 228 1124-1131.
7. Beck B, Richy S & Stricker-Krongrad A 2004 Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats. Life Sciences 76 473-478.
8. Chan JL, Bullen J, Lee JH, Yiannakouris N & Mantzoros CS 2004 Ghrelin levels are not regulated by recombinant leptin administration and/or three days of fasting in healthy subjects. Journal of Clinical Endocrinology and Metabolism 89 335-343.
9. Cowley MA 2003 Hypothalamic melanocortin neurons integrate signals of energy state. European Journal of Pharmacology 480 3-11.
10. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE & Weigle DS 2001 A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50 1714-1719.
11. Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, Matsuo H, Kangawa K & Nakazato M 2002 The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats, Gastroenterology 123 1120-1128.
12. Frederich RC, Lollmann B, Hamann A, Napolitano-Rosen A, Kahn BB, Lowell BB & Flier JS 1995 Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. Journal of Clinical Investigation 96 1658-1663.
13. Friedman JM & Halaas JL 1998 Leptin and the regulation of body weight in mammals. Nature 395 763-770.
14. Hosoda H, Kojima M, Matsuo H & Kangawa K 2000 Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochemical and Biophysical Research Communications 279 909-913.
15. Kamegai J, Tamura H, Shimizu S, Ishii S, Sugihara H & Oikawa S 2004 Effects of insulin, leptin, and glucagon on ghrelin secretion from isolated perfused rat stomach. Regulatory Peptides 119 77-81.
16. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H & Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 656-660.
17. Leroy P, Dessolin S, Villageois P, Moon BC, Friedman JM, Ailhaud G & Dani C 1996 Expression of ob gene in adipose cells. Regulation by insulin. Journal of Biological Chemistry 271 2365-2368.
18. Malagon MM, Luque RM, Ruiz-Guerrero E, Rodriguez-Pacheco F, Garcia-Navarro S, Casanueva FF, Gracia-Navarro F & Castano JP 2003 Intracellular signaling mechanisms mediating ghrelin-stimulated growth hormone release in somatotropes. Endocrinology 144 5372-5380.
19. Mix H, Widjaja A, Jandl O, Cornberg M, Kaul A, Goke M, Beil W, Kuske M, Brabant G, Manns MP et al. 2000 Expression of leptin and leptin receptor isoforms in the human stomach. Gut 47 481-486.
20. Nakazato M, Mutrakami N, Date Y, Kojima M, Matsuo H, Kangawa K & Matsukura S 2001 A role for ghrelin in the central regulation of feeding. Nature 409 194-198.
21. Pico C, Sanchez J, Oliver P & Palou A 2002 Leptin production by the stomach is up-regulated in obese (fa/fa) Zucker rats. Obesity Research 10 932-938.
22. Sakata I, Tanaka T, Yamazaki M, Tanizaki T, Zheng Z & Sakai T 2006 Gastric estrogen directly induces ghrelin expression and production in the rat stomach. Journal of Endocrinology 190 749-757.
23. Sanchez J, Oliver P, Palou A & Pico C 2004 The inhibition of gastric ghrelin production by food intake in rats is dependent on the type of macronutrient. Endocrinology 145 5049-5055.
24. Shimada M, Date Y, Mondal MS, Toshinai K, Shimbara T, Fukunaga K, Murakami N, Miyazato M, Kangawa K, Yoshimatsu H et al. 2003 Somatostatin suppresses ghrelin secretion from the rat stomach. Biochemical and Biophysical Research Communications 302 520-525.
25. Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, Hayashi T, Inoue G, Hosoda K, Kojima M et al. 2001 Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic pepticle that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50 227-232.
26. Silva AP, Bethmann K, Raulf F & Schmid HA 2005 Regulation of ghrelin secretion by somatostatin analogs in rats. European Journal of Endocrinology 152 887-894.
27. Sobhani I, Bado A, Vissuzaine C, Buyse M, Kermorgant S, Laigneau J, Attoub S, Lehy T, Henin D, Mignon M et al. 2000 Leptin secretion and leptin receptor in the human stomach. Gut 47 178-183.
28. Sobhani I, Buyse M, Goiot H, Weber N, Laigneau JP, Henin D, Soul JC & Bado A 2002 Vagal stimulation rapidly increases leptin secretion in human stomach. Gastroenterology 122 259-263.
29. Toshinai K, Mondal MS, Nakazato M, Date Y, Murakami N, Kojima M, Kangawa K & Matsukura S 2001 Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochemical and Biophysical Research Communications 281 1220-1225.
30. Tschop M, Smiley DL & Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407 908-913.
31. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E & Heiman ML 2001a Circulating ghrelin levels are decreased in human obesity. Diabetes 50 707-709.
32. Tschop M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R & Folwaczny C 2001b Post-prandial decrease of circulating human ghrelin levels. Journal of Endocrinological Investigation 24 RC19-RC21.
33. Ueyama T, Shirasawa N, Numazawa M, Yamada K, Shelangouski M, Ito T & Tsuruo Y 2002 Gastric parietal cells: potent endocrine role in secreting estrogen as a possible regulator of gastro-hepatic axis. Endocrinology 143 3162-3170.
34. Wang MY, Zhou YT, Newgard CB & Unger RH 1996 A novel leptin receptor isoform in rat. FEBS Letters 392 87-90.
35. Weigle DS, Duell PB, Connor WE, Steiner RA, Soules MR & Kuijper JL 1997 Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels. Journal of Clinical Endocrinology and Metabolism 82 561-565.
36. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DG, Ghatei MA et al. 2000 The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141 4325-4328.
37. Yamada H, Chen D, Monstein HJ & Hakanson R 1997 Effects of fasting on the expression of gastrin, cholecystokinin, and somatostatin genes and of various housekeeping genes in the pancreas and upper digestive tract of rats. Biochemical and Biophysical Research Communications 231 835-838.
38. Yamazaki M, Nakamura K, Kobayashi H, Matsubara M, Hayashi Y, Kangawa K & Sakai T 2002 Regulational effect of ghrelin on growth hormone secretion from perifused rat anterior pituitary cells. Journal of Neuroendocrinology 14 156-162.
39. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L & Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372 425-432.