Molecular allelokaryotyping of early-stage, untreated chronic lymphocytic leukemia

Cancer

Volumn 112, Issue 6, 2008, Pages 1296-1305

  Lehmann, Sören ^a,b   Ogawa, Seishi ^c   Raynaud, Sophie D ^d   Sanada, Masashi ^c   Nannya, Yasuhito ^c   Ticchioni, Michel ^d   Bastard, Christian ^e   Kawamata, Norihiko ^a   Koeffler, H Phillip ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF TOKYO   (Japan)

^d CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^e UNIVERSITÉ DE ROUEN   (France)

Author keywords

ATM; Cyclin D2; Micro RNA; TP53; Uniparental disomy

Indexed keywords

ATM PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; MICRORNA; PROTEIN KINASE ZAP 70; PROTEIN P53;

ADULT; AGED; ARTICLE; B CELL LEUKEMIA; CHROMOSOME 11Q; CHROMOSOME 13Q; CHROMOSOME 17P; CHROMOSOME 6Q; CHROMOSOME DELETION; CHROMOSOME DELETION 13; CHROMOSOME NUMBER; CHRONIC LYMPHATIC LEUKEMIA; CYTOGENETICS; DISOMY; DNA MICROARRAY; EARLY CANCER; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENOME; HOMOZYGOSITY; HUMAN; HUMAN CELL; KARYOTYPING; MAJOR CLINICAL STUDY; MALE; MOLECULAR GENETICS; PRIORITY JOURNAL; SAMPLE; SINGLE NUCLEOTIDE POLYMORPHISM; TRISOMY 12;

AGED; AGED, 80 AND OVER; ALLELES; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 13; COHORT STUDIES; DNA PRIMERS; FEMALE; FLOW CYTOMETRY; GENOME, HUMAN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 41149144139     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.23270     Document Type: Article

References (26)

1. Zwiebel JA, Cheson BD. Chronic lymphocytic leukemia: staging and prognostic factors. Semin Oncol. 1998;25:42-59.
2. Seiler T, Dohner H, Stilgenbauer S. Risk stratification in chronic lymphocytic leukemia. Semin Oncol. 2006;33:186-194.
3. Binet JL, Caligaris-Cappio F, Catovsky D, et al. Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia. Blood. 2006;107:859-861.
4. Oscier D, Fegan C, Hillmen P, et al. Guidelines on the diagnosis and management of chronic lymphocytic leukaemia. Br J Haematol. 2004;125:294-317.
5. Shanafelt TD, Geyer SM, Kay NE. Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL. Blood. 2004;103:1202-1210.
6. Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000;343:1910-1916.
7. Migliazza A, Bosch F, Komatsu H, et al. Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia. Blood. 2001;97:2098-2104.
8. Bullrich F, Fujii H, Calin G, et al. Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene. Cancer Res. 2001;61:6640-6648.
9. Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA. 2002;99:15524-15529.
10. Calin GA, Ferracin M, Cimmino A, et al. MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 2005;353:1793-1801.
11. Lindblad-Toh K, Tanenbaum DM, Daly MJ, et al. Loss-ofheterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays. Nat Biotechnol. 2000;18:1001-1005.
12. Nannya Y, Sanada M, Nakazaki K, et al. A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays. Cancer Res. 2005;65:6071-6079.
13. Yamamoto G, Nannya Y, Kato M, et al. Highly sensitive method for genome-wide detection of allelic composition in non-paired, primary tumor specimens using SNP genotyping micorarrays. Am J Hum Genet. 2007;81:114-126.
14. Matutes E, Owusu-Ankomah K, Morilla R, et al. The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia. 1994;8:1640-1645.
15. Sambrook J, Russell DW. Molecular Cloning: A Laboratory Manual. 3rd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 2001.
16. Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med. 2003;348:1764-1775.
17. Xiong Z, Laird PW. COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res. 1997;25:2532-2534.
18. Kalachikov S, Migliazza A, Cayanis E, et al. Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia. Genomics. 1997;42:369-377.
19. Largaespada DA. Haploinsufficiency for tumor suppression: the hazards of being single and living a long time. J Exp Med. 2001;193:F15-F18.
20. Stankovic T, Weber P, Stewart G, et al. Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia. Lancet. 1999;353:26-29.
21. Pfeifer D, Pantic M, Skatulla I, et al. Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays. Blood. 2007;109:1202-1210.
22. Robak T, Kasznicki M. Alkylating agents and nucleoside analogues in the treatment of B cell chronic lymphocytic leukemia. Leukemia. 2002;16:1015-1027.
23. Karp JE, Smith MA. The molecular pathogenesis of treatment-induced (secondary) leukemias: foundations for treatment and prevention. Semin Oncol. 1997;24:103-113.
24. Bosanquet AG, Bell PB. Novel ex vivo analysis of nonclassical, pleiotropic drug resistance and collateral sensitivity induced by therapy provides a rationale for treatment strategies in chronic lymphocytic leukemia. Blood. 1996;87:1962-1971.
25. Yoon S, De Micheli G. Prediction of regulatory modules comprising microRNAs and target genes. Bioinformatics. 2005;21(suppl 2):ii93-ii100.
26. Delmer A, Ajchenbaum-Cymbalista F, Tang R, et al. Overexpression of cyclin D2 in chronic B-cell malignancies. Blood. 1995;85:2870-2876.