Downregulated expression in high IgA (HIGA) mice and the renal protective role of meprinβ

Life Sciences

Volumn 82, Issue 15-16, 2008, Pages 899-908

  Yoshimura, Hiromitsu ^a   Ito, Masayoshi ^b   Kuwahara, Yusuke ^a   Ishii, Aiko ^a   Tsuritani, Katsuki ^a   Nakamura, Atsushi ^a   Hirasawa, Yasushi ^b   Nagamatsu, Tadashi ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b MEIJO UNIVERSITY   (Japan)

Author keywords

Anti GBM antibody associated nephritis; cDNA microarray; Extracellular matrix; HIGA mice; IgA nephropathy; Meprin

Indexed keywords

ACTINONIN; GLOMERULUS BASEMENT MEMBRANE ANTIBODY; IMMUNOGLOBULIN A; MEPRIN; MEPRIN ALPHA; MEPRIN BETA; METALLOPROTEINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EXTRACELLULAR MATRIX; FEMALE; FUNCTIONAL PROTEOMICS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLOMERULONEPHRITIS; GLOMERULUS; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY INJURY; MESANGIUM CELL; MICROARRAY ANALYSIS; MOUSE; NEPHRITIS; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RENAL PROTECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE; BODY WEIGHT; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; GENE EXPRESSION PROFILING; HYDROXAMIC ACIDS; IMMUNOGLOBULIN A; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY GLOMERULUS; METALLOENDOPEPTIDASES; MICE; MICE, INBRED BALB C; MICE, INBRED ICR; PROTEINURIA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; URODYNAMICS;

MUS;

EID: 41149143503     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2008.02.006     Document Type: Article

References (28)

1. Arthur M.J. Fibrosis and altered matrix degradation. Digestion 59 4 (1998) 376-380
2. Bertenshaw G.P., Turk B.E., Hubbard S.J., Matters G.L., Bylander J.E., Crisman J.M., Cantley L.C., and Bond J.S. Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity. Journal of Biological Chemistry 276 16 (2001) 13248-13255
3. Blobe G.C., Schiemann W.P., and Lodish H.F. Role of transforming growth factor beta in human disease. New England Journal of Medicine 4, 342 18 (2000) 1350-1358
4. Bond J.S., and Beynon R.J. The astacin family of metalloendopeptidases. Protein Science 4 (1995) 1247-1261
5. Bond J.S., Matters G.L., Banerjee S., and Dusheck R.E. Meprin metalloproteinase expression and regulation in kidney, intestine, urinary tract infections and cancer. FEBS Letters 579 (2005) 3317-3322
6. Carmago S., Shah S.V., and Walker P.D. Meprin, a brush-border enzyme, plays an important role in hypoxic/ischemic acute renal tubular injury in rats. Kidney International 61 (2002) 959-966
7. Chestukhin A., Litovchick L., Muradov K., Batkin M., and Shaltiel S. Unveiling the substrate specificity of meprinβ on the basis of the site in protein kinase A cleaved by the kinase splitting membranal proteinase. Journal of Biological Chemistry 272 6 (1997) 3153-3160
8. Crisman J.M., Zhang B., Norman L.P., and Bond J.S. Deletion of the meprinβ metalloprotease gene diminishes the ability of leukocytes to disseminate through extracellular matrix. Journal of Immunology 172 (2004) 4510-4519
9. Donadio J.V., and Grande J.P. IgA nephropathy. New England Journal of Medicine 347 10 (2002) 738-748
10. Katsuma S., Shiojima S., Hirasawa A., Suzuki Y., Takagaki K., Murai M., Kaminishi Y., Hada Y., Koba M., Muso E., Miyawaki S., Ohgi T., Yano J., and Tsujimoto G. Genomic analysis of a mouse model of immunoglobulin A nephropathy reveals an enhanced PDGF-EDG5 cascade. Pharmacogenomics Journal 1 3 (2001) 211-217
11. Kaushal G.P., Walker P.D., and Shah S.V. An old enzyme with a new function: purification and characterization of a distinct matrix-degrading metalloproteinase in rat kidney cortex and its identification as meprin. Journal of Cell Biology 126 5 (1994) 1319-1327
12. Kieran N.E., Doran P.P., Connolly S.B., Greenan M.C., Higgins D.F., Leonard M., Godson C., Taylor C.T., Henger A., Kretzler M., Burne M.J., Rabb H., and Brady H.R. Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog. Kidney International 64 (2003) 480-492
13. Kruse M.N., Becker C., Lottaz D., Kohler D., Yiallouros I., Krell H.W., Sterchi E.E., and Stocker W. Human meprinα and β homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloproteinase inhibitors. Biochemical Journal 378 (2004) 383-389
14. Levy M., and Berger J. Worldwide perspective of IgA nephropathy. American Journal of Kidney Diseases 12 5 (1988) 340-347
15. Massague J. The transforming growth factor-beta family. Annual Review of Cell Biology 6 (1990) 597-641
16. Mathew R., Futterweit S., Valderrama E., Tarectecan A.A., Bylander J.E., Bond J.S., and Trachtman H. Meprin-α in chronic diabetic nephropathy: interaction with the renin-angiotensin axis. American Journal of Physiology. Renal Physiology 289 (2005) F911-F921
17. Miyawaki S., Muso E., Takeuchi E., Matsushima H., Shibata Y., Sasayama S., and Yoshida H. Selective breeding for high serum IgA levels from noninbred ddY mice: isolation of a strain with an early onset of glomerular IgA deposition. Nephron 76 2 (1997) 201-207
18. Muso E., Yoshida H., Takeuchi E., Yashiro M., Matsushima H., Oyama A., Suyama K., Kawamura T., Kamata T., Miyawaki-Izui S., and Sasayama S. Enhanced production of glomerular extracellular matrix in a new mouse strain of high serum IgA ddY mice. Kidney International 50 6 (1996) 1946-1957
19. Nagamatsu T., Hayashi K., Oka T., and Suzuki Y. Angiotensin II type I receptor antagonist suppresses proteinuria and glomerular lesions in experimental nephritis. European Journal Pharmacology 374 1 (1999) 93-101
20. Nagamatsu T., Imai H., Yokoi M., Nishiyama T., Hirasawa Y., Nagao T., and Suzuki Y. Protective effect of prostaglandin EP4-Receptor agonist on anti-glomerular basement membrane antibody-associated nephritis. Journal of Pharmacological Sciences 102 2 (2006) 182-188
21. Nagase H., and Woessner Jr. J.F. Matrix metalloproteinases. Journal of Biological Chemistry 274 31 (1999) 21491-21494
22. Norman L.P., Jiang W., Han X., Saunders T.L., and Bond J.S. Targeted disruption of the meprin beta gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles. Molecular and Cellular Biology 23 4 (2003) 1221-1230
23. Red Eagle A.R., Hanson R.L., Jiang W., Han X., Matters G.L., Imperatore G., Knowler W.C., and Bond J.S. Meprin beta metalloproteinase gene polymorphisms associated with diabetic nephropathy in the Pima Indians. Human Genetics 118 1 (2005) 12-22
24. Ricardo S.D., Bond J.S., Johnson G.D., Kaspar J., and Diamond J.R. Expression of subunits of the metalloendopeptidase meprin in renal cortex in experimental hydronephrosis. American Journal of Physiology. Renal Physiology 270 (1996) F669-F676
25. Ruiz-Torres M.P., López-Ongil S., Griera M., Díez-Marqués M.L., Rodríguez-Puyol M., and Rodríguez-Puyol D. The accumulation of extracellular matrix in the kidney: consequences on cellular function. Journal of Nephrology 18 (2005) 334-340
26. Sadlier D.M., Connolly S.B., Kieran N.E., Roxburgh S., Brazil D.P., Kairaitis L., Wang Y., Harris D.C.H., Doran P., and Brady H.R. Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy. Journal of Biological Chemistry 279 28 (2004) 29670-29680
27. Takemoto M., Asker N., Gerhardt H., Lundkvist A., Johansson B.R., Saito Y., and Betsholtz C. A new method for large scale isolation of kidney glomeruli from mice. American Journal of Pathology 161 (2002) 799-805
28. Walker P.D., Kaushal G.P., and Shah S.V. Meprin A, the major matrix degrading enzyme in renal tubules, produces a novel nidogen fragment in vitro and in vivo. Kidney International 53 (1998) 1673-1680