GRIM-19 mutations are not associated with Crohn's disease

Inflammatory Bowel Diseases

Volumn 14, Issue 3, 2008, Pages 434-435

  Ferreira, António Carlos ^a,b   Gomes, Lígia ^a   Máximo, Valdemar ^a,b   Amil, Jorge ^c   Carneiro, Fátima ^a,b   Machado, José Carlos ^a,b   Tavarela Veloso, Fernando ^c  

^a UNIVERSITY OF PORTO   (Portugal)

^b Institute of Pharmacology and Therapeutics   (Portugal)

^c HOSPITAL DE SÃO JOÃO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; MESSENGER RNA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CROHN DISEASE; EPIGENETICS; EXON; GENE; GENE AMPLIFICATION; GENE EXPRESSION; GENE LOCATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC SCREENING; GRIM 19 GENE; HETEROZYGOSITY; HUMAN; LETTER; MUTATIONAL ANALYSIS; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ALLELES; APOPTOSIS REGULATORY PROTEINS; BIOPSY; CROHN DISEASE; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HUMANS; MUTATION; NADH, NADPH OXIDOREDUCTASES; NOD2 SIGNALING ADAPTOR PROTEIN; POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 41149124981     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.20313     Document Type: Letter

References (7)

1. Barnich N, Hisamatsu T, Aguirre JE, et al. GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells. J Biol Chem. 2005;280:19021-19026.
2. Huang G, Lu H, Hao A, et al. GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I. Mol Cell Biol. 2004;24:8447-8456.
3. Fearnley IM, Carroll J, Shannon RJ, et al. GRIM-19, a cell death regulatory gene product, is a subunit of bovine mitochondrial NADH: ubiquinone oxidoreductase (complex I). J Biol Chem. 2001;276:38345-38348.
4. Angell JE, Lindner DJ, Shapiro PS, et al. Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach. J Biol Chem. 2000;275:33416-33426.
5. Lufei C, Ma J, Huang G, et al. GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction. EMBO J. 2003;22:1325-1335.
6. Ferreira AC, Almeida S, Tavares M, et al. NOD2/CARD15 and TNFA, but not IL1B and IL1RN, are associated with Crohn's disease. Inflamm Bowel Dis. 2005;11:331-339.
7. Maximo V, Botelho T, Capela J, et al. Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid. Br J Cancer. 2005;92:1892-1898.